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Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study

Psoriasis, vitiligo and lichen planus (LP) are autoimmune skin diseases associated with metabolic syndrome. Angiopoietin-like 4 (ANGPTL4) is a member of angiopoietin-like proteins, which play an important role in lipid metabolism, and its serum concentration has been proposed as a biomarker of cardi...

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Autores principales: Nowowiejska, Julia, Baran, Anna, Hermanowicz, Justyna Magdalena, Mikłosz, Joanna, Kamiński, Karol Adam, Kondraciuk, Marcin, Dubatówka, Marlena, Pawlak, Dariusz, Flisiak, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500972/
https://www.ncbi.nlm.nih.gov/pubmed/36144281
http://dx.doi.org/10.3390/metabo12090877
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author Nowowiejska, Julia
Baran, Anna
Hermanowicz, Justyna Magdalena
Mikłosz, Joanna
Kamiński, Karol Adam
Kondraciuk, Marcin
Dubatówka, Marlena
Pawlak, Dariusz
Flisiak, Iwona
author_facet Nowowiejska, Julia
Baran, Anna
Hermanowicz, Justyna Magdalena
Mikłosz, Joanna
Kamiński, Karol Adam
Kondraciuk, Marcin
Dubatówka, Marlena
Pawlak, Dariusz
Flisiak, Iwona
author_sort Nowowiejska, Julia
collection PubMed
description Psoriasis, vitiligo and lichen planus (LP) are autoimmune skin diseases associated with metabolic syndrome. Angiopoietin-like 4 (ANGPTL4) is a member of angiopoietin-like proteins, which play an important role in lipid metabolism, and its serum concentration has been proposed as a biomarker of cardiometabolic complications, especially coronary artery disease (CAD). The study involved 56 patients with abovementioned dermatoses and 29 sex- and age-matched volunteers without dermatoses. ANGPTL4 serum concentration was measured by ELISA. ANGPTL4 concentration was statistically significantly higher in patients with LP compared to the control group (p < 0.01); moreover, it was significantly higher than in patients with psoriasis and vitiligo (p < 0.001, p < 0.01, respectively). There was no statistically significant difference in ANGPTL4 concentration between patients with psoriasis or vitiligo and controls. There was no correlation between ANGPTL4 concentration and age or BMI in all study groups. There was a positive correlation between ANGPTL4 concentration and fasting glucose (R = 0.43) and AST activity (R = 0.39) in psoriatic patients and ALT activity in patients with vitiligo (R = 0.44). ANGPTL4 could be a potential marker of metabolic complications in patients with LP, especially CAD. Perhaps patients with LP are more prone to CAD compared to the other two dermatoses, which requires further research.
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spelling pubmed-95009722022-09-24 Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study Nowowiejska, Julia Baran, Anna Hermanowicz, Justyna Magdalena Mikłosz, Joanna Kamiński, Karol Adam Kondraciuk, Marcin Dubatówka, Marlena Pawlak, Dariusz Flisiak, Iwona Metabolites Communication Psoriasis, vitiligo and lichen planus (LP) are autoimmune skin diseases associated with metabolic syndrome. Angiopoietin-like 4 (ANGPTL4) is a member of angiopoietin-like proteins, which play an important role in lipid metabolism, and its serum concentration has been proposed as a biomarker of cardiometabolic complications, especially coronary artery disease (CAD). The study involved 56 patients with abovementioned dermatoses and 29 sex- and age-matched volunteers without dermatoses. ANGPTL4 serum concentration was measured by ELISA. ANGPTL4 concentration was statistically significantly higher in patients with LP compared to the control group (p < 0.01); moreover, it was significantly higher than in patients with psoriasis and vitiligo (p < 0.001, p < 0.01, respectively). There was no statistically significant difference in ANGPTL4 concentration between patients with psoriasis or vitiligo and controls. There was no correlation between ANGPTL4 concentration and age or BMI in all study groups. There was a positive correlation between ANGPTL4 concentration and fasting glucose (R = 0.43) and AST activity (R = 0.39) in psoriatic patients and ALT activity in patients with vitiligo (R = 0.44). ANGPTL4 could be a potential marker of metabolic complications in patients with LP, especially CAD. Perhaps patients with LP are more prone to CAD compared to the other two dermatoses, which requires further research. MDPI 2022-09-17 /pmc/articles/PMC9500972/ /pubmed/36144281 http://dx.doi.org/10.3390/metabo12090877 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Nowowiejska, Julia
Baran, Anna
Hermanowicz, Justyna Magdalena
Mikłosz, Joanna
Kamiński, Karol Adam
Kondraciuk, Marcin
Dubatówka, Marlena
Pawlak, Dariusz
Flisiak, Iwona
Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study
title Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study
title_full Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study
title_fullStr Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study
title_full_unstemmed Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study
title_short Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study
title_sort angiopoietin-like 4 (angptl4) in patients with psoriasis, lichen planus and vitiligo—a pilot study from the bialystok+ polish longitudinal university study
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500972/
https://www.ncbi.nlm.nih.gov/pubmed/36144281
http://dx.doi.org/10.3390/metabo12090877
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