Cargando…

Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs

According to the World Health Organization, in 2018, cancers, along with over 18 million new cases and over 9.5 million deaths remained one of the main causes of mortality globally. Cancer-cachexia, also called wasting syndrome is a complex, multifactorial disorder characterized by progressive skele...

Descripción completa

Detalles Bibliográficos
Autores principales: Homa-Mlak, Iwona, Pigoń-Zając, Dominika, Wawrejko, Paweł, Małecka-Massalska, Teresa, Mlak, Radosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500979/
https://www.ncbi.nlm.nih.gov/pubmed/36143223
http://dx.doi.org/10.3390/jpm12091438
_version_ 1784795357295673344
author Homa-Mlak, Iwona
Pigoń-Zając, Dominika
Wawrejko, Paweł
Małecka-Massalska, Teresa
Mlak, Radosław
author_facet Homa-Mlak, Iwona
Pigoń-Zając, Dominika
Wawrejko, Paweł
Małecka-Massalska, Teresa
Mlak, Radosław
author_sort Homa-Mlak, Iwona
collection PubMed
description According to the World Health Organization, in 2018, cancers, along with over 18 million new cases and over 9.5 million deaths remained one of the main causes of mortality globally. Cancer-cachexia, also called wasting syndrome is a complex, multifactorial disorder characterized by progressive skeletal muscle mass loss, with or without adipose tissue atrophy. It is considered as a state of cancer-related malnutrition (CRM) accompanied by inflammation, that is irreversible despite the introduction of nutritional support. Indication of markers of pre-cachectic state seems to be urgently needed. Moreover, such markers have also potential to be used in the assessment of the effects of anti-cachexia treatment, and prognosis. miRNAs are non-coding RNA molecules that are about 20–30 nucleotides long. Single miRNA has the potential to control from few dozen to several hundred different genes. Despite the fact, that the number of miRNAs keep growing. we are making steady progress in establishing regulatory targets and their physiological levels. In this review we described the current knowledge on the impact of miRNAs on processes involved in cancer cachexia development: inflammation, adipose tissue remodelling, and loss of muscle mass both in animal models and the human cohorts. The available studies suggest that miRNAs, due to their properties, e.g., the possibility of regulating even hundreds of different genes, signalling pathways, and biological processes by one molecule, but also due their stability in biological material, the fact, that the change in their level reflects the disease status or the response to the applied treatment, they have great potential to be used as valuable biomarkers in the diagnosis, treatment, and prognosis of cancer cachexia.
format Online
Article
Text
id pubmed-9500979
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95009792022-09-24 Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs Homa-Mlak, Iwona Pigoń-Zając, Dominika Wawrejko, Paweł Małecka-Massalska, Teresa Mlak, Radosław J Pers Med Review According to the World Health Organization, in 2018, cancers, along with over 18 million new cases and over 9.5 million deaths remained one of the main causes of mortality globally. Cancer-cachexia, also called wasting syndrome is a complex, multifactorial disorder characterized by progressive skeletal muscle mass loss, with or without adipose tissue atrophy. It is considered as a state of cancer-related malnutrition (CRM) accompanied by inflammation, that is irreversible despite the introduction of nutritional support. Indication of markers of pre-cachectic state seems to be urgently needed. Moreover, such markers have also potential to be used in the assessment of the effects of anti-cachexia treatment, and prognosis. miRNAs are non-coding RNA molecules that are about 20–30 nucleotides long. Single miRNA has the potential to control from few dozen to several hundred different genes. Despite the fact, that the number of miRNAs keep growing. we are making steady progress in establishing regulatory targets and their physiological levels. In this review we described the current knowledge on the impact of miRNAs on processes involved in cancer cachexia development: inflammation, adipose tissue remodelling, and loss of muscle mass both in animal models and the human cohorts. The available studies suggest that miRNAs, due to their properties, e.g., the possibility of regulating even hundreds of different genes, signalling pathways, and biological processes by one molecule, but also due their stability in biological material, the fact, that the change in their level reflects the disease status or the response to the applied treatment, they have great potential to be used as valuable biomarkers in the diagnosis, treatment, and prognosis of cancer cachexia. MDPI 2022-08-31 /pmc/articles/PMC9500979/ /pubmed/36143223 http://dx.doi.org/10.3390/jpm12091438 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Homa-Mlak, Iwona
Pigoń-Zając, Dominika
Wawrejko, Paweł
Małecka-Massalska, Teresa
Mlak, Radosław
Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs
title Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs
title_full Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs
title_fullStr Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs
title_full_unstemmed Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs
title_short Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs
title_sort three pathways of cancer cachexia: inflammation, changes in adipose tissue and loss of muscle mass—the role of mirnas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500979/
https://www.ncbi.nlm.nih.gov/pubmed/36143223
http://dx.doi.org/10.3390/jpm12091438
work_keys_str_mv AT homamlakiwona threepathwaysofcancercachexiainflammationchangesinadiposetissueandlossofmusclemasstheroleofmirnas
AT pigonzajacdominika threepathwaysofcancercachexiainflammationchangesinadiposetissueandlossofmusclemasstheroleofmirnas
AT wawrejkopaweł threepathwaysofcancercachexiainflammationchangesinadiposetissueandlossofmusclemasstheroleofmirnas
AT małeckamassalskateresa threepathwaysofcancercachexiainflammationchangesinadiposetissueandlossofmusclemasstheroleofmirnas
AT mlakradosław threepathwaysofcancercachexiainflammationchangesinadiposetissueandlossofmusclemasstheroleofmirnas