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Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power

Micro-RNAs (miRNAs) are short non-coding single-stranded RNAs that modulate the expression of various target genes after transcription. The expression and distribution of kinds of miRNAs have been characterized in human placenta during different gestational stages. The identified miRNAs are recogniz...

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Detalles Bibliográficos
Autores principales: Jin, Meiyuan, Xu, Qiang, Li, Jiayong, Xu, Shouying, Tang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501247/
https://www.ncbi.nlm.nih.gov/pubmed/36144676
http://dx.doi.org/10.3390/molecules27185943
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author Jin, Meiyuan
Xu, Qiang
Li, Jiayong
Xu, Shouying
Tang, Chao
author_facet Jin, Meiyuan
Xu, Qiang
Li, Jiayong
Xu, Shouying
Tang, Chao
author_sort Jin, Meiyuan
collection PubMed
description Micro-RNAs (miRNAs) are short non-coding single-stranded RNAs that modulate the expression of various target genes after transcription. The expression and distribution of kinds of miRNAs have been characterized in human placenta during different gestational stages. The identified miRNAs are recognized as key mediators in the regulation of placental development and in the maintenance of human pregnancy. Aberrant expression of miRNAs is associated with compromised pregnancies in humans, and dysregulation of those miRNAs contributes to the occurrence and development of related diseases during pregnancy, such as pre-eclampsia (PE), fetal growth restriction (FGR), gestational diabetes mellitus (GDM), recurrent miscarriage, preterm birth (PTB) and small-for-gestational-age (SGA). Thus, having a better understanding of the expression and functions of miRNAs in human placenta during pregnancy and thereby developing novel drugs targeting the miRNAs could be a potentially promising method in the prevention and treatment of relevant diseases in future. Here, we summarize the current knowledge of the expression pattern and function regulation of miRNAs in human placental development and related diseases.
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spelling pubmed-95012472022-09-24 Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power Jin, Meiyuan Xu, Qiang Li, Jiayong Xu, Shouying Tang, Chao Molecules Review Micro-RNAs (miRNAs) are short non-coding single-stranded RNAs that modulate the expression of various target genes after transcription. The expression and distribution of kinds of miRNAs have been characterized in human placenta during different gestational stages. The identified miRNAs are recognized as key mediators in the regulation of placental development and in the maintenance of human pregnancy. Aberrant expression of miRNAs is associated with compromised pregnancies in humans, and dysregulation of those miRNAs contributes to the occurrence and development of related diseases during pregnancy, such as pre-eclampsia (PE), fetal growth restriction (FGR), gestational diabetes mellitus (GDM), recurrent miscarriage, preterm birth (PTB) and small-for-gestational-age (SGA). Thus, having a better understanding of the expression and functions of miRNAs in human placenta during pregnancy and thereby developing novel drugs targeting the miRNAs could be a potentially promising method in the prevention and treatment of relevant diseases in future. Here, we summarize the current knowledge of the expression pattern and function regulation of miRNAs in human placental development and related diseases. MDPI 2022-09-13 /pmc/articles/PMC9501247/ /pubmed/36144676 http://dx.doi.org/10.3390/molecules27185943 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jin, Meiyuan
Xu, Qiang
Li, Jiayong
Xu, Shouying
Tang, Chao
Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power
title Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power
title_full Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power
title_fullStr Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power
title_full_unstemmed Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power
title_short Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power
title_sort micro-rnas in human placenta: tiny molecules, immense power
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501247/
https://www.ncbi.nlm.nih.gov/pubmed/36144676
http://dx.doi.org/10.3390/molecules27185943
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