Anti-Inflammatory Activity of Soluble Epoxide Hydrolase Inhibitors Based on Selenoureas Bearing an Adamantane Moiety

The inhibitory potency of the series of inhibitors of the soluble epoxide hydrolase (sEH) based on the selenourea moiety and containing adamantane and aromatic lipophilic groups ranges from 34.3 nM to 1.2 μM. The most active compound 5d possesses aliphatic spacers between the selenourea group and li...

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Detalles Bibliográficos
Autores principales: Burmistrov, Vladimir, Morisseau, Christophe, Babkov, Denis A., Golubeva, Tatiana, Pitushkin, Dmitry, Sokolova, Elena V., Vasipov, Vladimir, Kuznetsov, Yaroslav, Bazhenov, Sergey V., Novoyatlova, Uliana S., Bondarev, Nikolay A., Manukhov, Ilya V., Osipova, Victoria, Berberova, Nadezhda, Spasov, Alexander A., Butov, Gennady M., Hammock, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501280/
https://www.ncbi.nlm.nih.gov/pubmed/36142611
http://dx.doi.org/10.3390/ijms231810710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501280/
https://www.ncbi.nlm.nih.gov/pubmed/36142611
http://dx.doi.org/10.3390/ijms231810710

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