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Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model

Neurodegenerative diseases such as Parkinson’s disease (PD) are known to be related to oxidative stress and neuroinflammation, and thus, modulating neuroinflammation offers a possible means of treating PD-associated pathologies. Morin (2′,3,4′,5,7-pentahydroxy flavone) is a flavonol with anti-oxidat...

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Autores principales: Hong, Dong Geun, Lee, Seulah, Kim, Jaehoon, Yang, Seonguk, Lee, Myunggyo, Ahn, Jinsook, Lee, Haeseung, Chang, Seung-Cheol, Ha, Nam-Chul, Lee, Jaewon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501291/
https://www.ncbi.nlm.nih.gov/pubmed/36142491
http://dx.doi.org/10.3390/ijms231810578
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author Hong, Dong Geun
Lee, Seulah
Kim, Jaehoon
Yang, Seonguk
Lee, Myunggyo
Ahn, Jinsook
Lee, Haeseung
Chang, Seung-Cheol
Ha, Nam-Chul
Lee, Jaewon
author_facet Hong, Dong Geun
Lee, Seulah
Kim, Jaehoon
Yang, Seonguk
Lee, Myunggyo
Ahn, Jinsook
Lee, Haeseung
Chang, Seung-Cheol
Ha, Nam-Chul
Lee, Jaewon
author_sort Hong, Dong Geun
collection PubMed
description Neurodegenerative diseases such as Parkinson’s disease (PD) are known to be related to oxidative stress and neuroinflammation, and thus, modulating neuroinflammation offers a possible means of treating PD-associated pathologies. Morin (2′,3,4′,5,7-pentahydroxy flavone) is a flavonol with anti-oxidative and anti-inflammatory effects found in wines, herbs, and fruits. The present study was undertaken to determine whether a morin-containing diet has protective effects in an MPTP-induced mouse model of PD. Mice were fed a control or morin diet for 34 days, and then MPTP (30 mg/kg, i.p.) was administered daily for 5 days to induce a PD-like pathology. We found that dietary morin prevented MPTP-induced motor dysfunction and ameliorated dopaminergic neuronal damage in striatum (STR) and substantia nigra (SN) in our mouse model. Furthermore, MPTP-induced neuroinflammation was significantly reduced in mice fed morin. In vitro studies showed that morin effectively suppressed glial activations in primary microglia and astrocytes, and biochemical analysis and a docking simulation indicated that the anti-inflammatory effects of morin were mediated by blocking the extracellular signal-regulated kinase (ERK)-p65 pathway. These findings suggest that morin effectively inhibits glial activations and has potential use as a functional food ingredient with therapeutic potential for the treatment of PD and other neurodegenerative diseases associated with neuroinflammation.
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spelling pubmed-95012912022-09-24 Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model Hong, Dong Geun Lee, Seulah Kim, Jaehoon Yang, Seonguk Lee, Myunggyo Ahn, Jinsook Lee, Haeseung Chang, Seung-Cheol Ha, Nam-Chul Lee, Jaewon Int J Mol Sci Article Neurodegenerative diseases such as Parkinson’s disease (PD) are known to be related to oxidative stress and neuroinflammation, and thus, modulating neuroinflammation offers a possible means of treating PD-associated pathologies. Morin (2′,3,4′,5,7-pentahydroxy flavone) is a flavonol with anti-oxidative and anti-inflammatory effects found in wines, herbs, and fruits. The present study was undertaken to determine whether a morin-containing diet has protective effects in an MPTP-induced mouse model of PD. Mice were fed a control or morin diet for 34 days, and then MPTP (30 mg/kg, i.p.) was administered daily for 5 days to induce a PD-like pathology. We found that dietary morin prevented MPTP-induced motor dysfunction and ameliorated dopaminergic neuronal damage in striatum (STR) and substantia nigra (SN) in our mouse model. Furthermore, MPTP-induced neuroinflammation was significantly reduced in mice fed morin. In vitro studies showed that morin effectively suppressed glial activations in primary microglia and astrocytes, and biochemical analysis and a docking simulation indicated that the anti-inflammatory effects of morin were mediated by blocking the extracellular signal-regulated kinase (ERK)-p65 pathway. These findings suggest that morin effectively inhibits glial activations and has potential use as a functional food ingredient with therapeutic potential for the treatment of PD and other neurodegenerative diseases associated with neuroinflammation. MDPI 2022-09-12 /pmc/articles/PMC9501291/ /pubmed/36142491 http://dx.doi.org/10.3390/ijms231810578 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hong, Dong Geun
Lee, Seulah
Kim, Jaehoon
Yang, Seonguk
Lee, Myunggyo
Ahn, Jinsook
Lee, Haeseung
Chang, Seung-Cheol
Ha, Nam-Chul
Lee, Jaewon
Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model
title Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model
title_full Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model
title_fullStr Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model
title_full_unstemmed Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model
title_short Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model
title_sort anti-inflammatory and neuroprotective effects of morin in an mptp-induced parkinson’s disease model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501291/
https://www.ncbi.nlm.nih.gov/pubmed/36142491
http://dx.doi.org/10.3390/ijms231810578
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