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Mitotane Nanocarriers for the Treatment of Adrenocortical Carcinoma: Evaluation of Albumin-Stabilized Nanoparticles and Liposomes in a Preclinical In Vitro Study with 3D Spheroids

Adrenocortical carcinoma (ACC) is a heterogeneous malignancy related to poor prognosis and limited treatment options. The orphan drug mitotane (MT) is still a cornerstone in ACC therapy, however, its application is characterized by low aqueous solubility, poor bioavailability, and unfavorable pharma...

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Detalles Bibliográficos
Autores principales:	Langer, Carolin, Köll-Weber, Monika, Holzer, Martin, Hantel, Constanze, Süss, Regine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501383/ https://www.ncbi.nlm.nih.gov/pubmed/36145639 http://dx.doi.org/10.3390/pharmaceutics14091891

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