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The Effect of Vitamin D and Its Analogs in Ovarian Cancer
Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapie...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501475/ https://www.ncbi.nlm.nih.gov/pubmed/36145244 http://dx.doi.org/10.3390/nu14183867 |
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author | Piatek, Karina Schepelmann, Martin Kallay, Enikö |
author_facet | Piatek, Karina Schepelmann, Martin Kallay, Enikö |
author_sort | Piatek, Karina |
collection | PubMed |
description | Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapies with fewer side effects, or adjuvant therapies, which could reduce the necessary doses of chemotherapeutics. Vitamin D is one of the main regulators of serum calcium and phosphorus homeostasis, but it has also anticancer effects. It induces differentiation and apoptosis, reduces proliferation and metastatic potential of cancer cells. However, doses that would be effective against cancer cause hypercalcemia. For this reason, synthetic and less calcemic analogs have been developed and tested in terms of their anticancer effect. The anticancer role of vitamin D is best understood in colorectal, breast, and prostate cancer and much less research has been done in ovarian cancer. In this review, we thus summarize the studies on the role of vitamin D and its analogs in vitro and in vivo in ovarian cancer models. |
format | Online Article Text |
id | pubmed-9501475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95014752022-09-24 The Effect of Vitamin D and Its Analogs in Ovarian Cancer Piatek, Karina Schepelmann, Martin Kallay, Enikö Nutrients Review Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapies with fewer side effects, or adjuvant therapies, which could reduce the necessary doses of chemotherapeutics. Vitamin D is one of the main regulators of serum calcium and phosphorus homeostasis, but it has also anticancer effects. It induces differentiation and apoptosis, reduces proliferation and metastatic potential of cancer cells. However, doses that would be effective against cancer cause hypercalcemia. For this reason, synthetic and less calcemic analogs have been developed and tested in terms of their anticancer effect. The anticancer role of vitamin D is best understood in colorectal, breast, and prostate cancer and much less research has been done in ovarian cancer. In this review, we thus summarize the studies on the role of vitamin D and its analogs in vitro and in vivo in ovarian cancer models. MDPI 2022-09-18 /pmc/articles/PMC9501475/ /pubmed/36145244 http://dx.doi.org/10.3390/nu14183867 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Piatek, Karina Schepelmann, Martin Kallay, Enikö The Effect of Vitamin D and Its Analogs in Ovarian Cancer |
title | The Effect of Vitamin D and Its Analogs in Ovarian Cancer |
title_full | The Effect of Vitamin D and Its Analogs in Ovarian Cancer |
title_fullStr | The Effect of Vitamin D and Its Analogs in Ovarian Cancer |
title_full_unstemmed | The Effect of Vitamin D and Its Analogs in Ovarian Cancer |
title_short | The Effect of Vitamin D and Its Analogs in Ovarian Cancer |
title_sort | effect of vitamin d and its analogs in ovarian cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501475/ https://www.ncbi.nlm.nih.gov/pubmed/36145244 http://dx.doi.org/10.3390/nu14183867 |
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