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The Effect of Vitamin D and Its Analogs in Ovarian Cancer

Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapie...

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Autores principales: Piatek, Karina, Schepelmann, Martin, Kallay, Enikö
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501475/
https://www.ncbi.nlm.nih.gov/pubmed/36145244
http://dx.doi.org/10.3390/nu14183867
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author Piatek, Karina
Schepelmann, Martin
Kallay, Enikö
author_facet Piatek, Karina
Schepelmann, Martin
Kallay, Enikö
author_sort Piatek, Karina
collection PubMed
description Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapies with fewer side effects, or adjuvant therapies, which could reduce the necessary doses of chemotherapeutics. Vitamin D is one of the main regulators of serum calcium and phosphorus homeostasis, but it has also anticancer effects. It induces differentiation and apoptosis, reduces proliferation and metastatic potential of cancer cells. However, doses that would be effective against cancer cause hypercalcemia. For this reason, synthetic and less calcemic analogs have been developed and tested in terms of their anticancer effect. The anticancer role of vitamin D is best understood in colorectal, breast, and prostate cancer and much less research has been done in ovarian cancer. In this review, we thus summarize the studies on the role of vitamin D and its analogs in vitro and in vivo in ovarian cancer models.
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spelling pubmed-95014752022-09-24 The Effect of Vitamin D and Its Analogs in Ovarian Cancer Piatek, Karina Schepelmann, Martin Kallay, Enikö Nutrients Review Ovarian cancer is one of the deadliest cancers in women, due to its heterogeneity and usually late diagnosis. The current first-line therapies of debulking surgery and intensive chemotherapy cause debilitating side effects. Therefore, there is an unmet medical need to find new and effective therapies with fewer side effects, or adjuvant therapies, which could reduce the necessary doses of chemotherapeutics. Vitamin D is one of the main regulators of serum calcium and phosphorus homeostasis, but it has also anticancer effects. It induces differentiation and apoptosis, reduces proliferation and metastatic potential of cancer cells. However, doses that would be effective against cancer cause hypercalcemia. For this reason, synthetic and less calcemic analogs have been developed and tested in terms of their anticancer effect. The anticancer role of vitamin D is best understood in colorectal, breast, and prostate cancer and much less research has been done in ovarian cancer. In this review, we thus summarize the studies on the role of vitamin D and its analogs in vitro and in vivo in ovarian cancer models. MDPI 2022-09-18 /pmc/articles/PMC9501475/ /pubmed/36145244 http://dx.doi.org/10.3390/nu14183867 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Piatek, Karina
Schepelmann, Martin
Kallay, Enikö
The Effect of Vitamin D and Its Analogs in Ovarian Cancer
title The Effect of Vitamin D and Its Analogs in Ovarian Cancer
title_full The Effect of Vitamin D and Its Analogs in Ovarian Cancer
title_fullStr The Effect of Vitamin D and Its Analogs in Ovarian Cancer
title_full_unstemmed The Effect of Vitamin D and Its Analogs in Ovarian Cancer
title_short The Effect of Vitamin D and Its Analogs in Ovarian Cancer
title_sort effect of vitamin d and its analogs in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501475/
https://www.ncbi.nlm.nih.gov/pubmed/36145244
http://dx.doi.org/10.3390/nu14183867
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