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Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities
Marine sponges continue to attract remarkable attention as one of the richest pools of bioactive metabolites in the marine environment. The genus Smenospongia (order Dictyoceratida, family Thorectidae) sponges can produce diverse classes of metabolites with unique and unusual chemical skeletons, inc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501515/ https://www.ncbi.nlm.nih.gov/pubmed/36144705 http://dx.doi.org/10.3390/molecules27185969 |
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author | Ibrahim, Sabrin R. M. Fadil, Sana A. Fadil, Haifa A. Hareeri, Rawan H. Abdallah, Hossam M. Mohamed, Gamal A. |
author_facet | Ibrahim, Sabrin R. M. Fadil, Sana A. Fadil, Haifa A. Hareeri, Rawan H. Abdallah, Hossam M. Mohamed, Gamal A. |
author_sort | Ibrahim, Sabrin R. M. |
collection | PubMed |
description | Marine sponges continue to attract remarkable attention as one of the richest pools of bioactive metabolites in the marine environment. The genus Smenospongia (order Dictyoceratida, family Thorectidae) sponges can produce diverse classes of metabolites with unique and unusual chemical skeletons, including terpenoids (sesqui-, di-, and sesterterpenoids), indole alkaloids, aplysinopsins, bisspiroimidazolidinones, chromenes, γ-pyrones, phenyl alkenes, naphthoquinones, and polyketides that possessed diversified bioactivities. This review provided an overview of the reported metabolites from Smenospongia sponges, including their biosynthesis, synthesis, and bioactivities in the period from 1980 to June 2022. The structural characteristics and diverse bioactivities of these metabolites could attract a great deal of attention from natural-product chemists and pharmaceuticals seeking to develop these metabolites into medicine for the treatment and prevention of certain health concerns. |
format | Online Article Text |
id | pubmed-9501515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95015152022-09-24 Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities Ibrahim, Sabrin R. M. Fadil, Sana A. Fadil, Haifa A. Hareeri, Rawan H. Abdallah, Hossam M. Mohamed, Gamal A. Molecules Review Marine sponges continue to attract remarkable attention as one of the richest pools of bioactive metabolites in the marine environment. The genus Smenospongia (order Dictyoceratida, family Thorectidae) sponges can produce diverse classes of metabolites with unique and unusual chemical skeletons, including terpenoids (sesqui-, di-, and sesterterpenoids), indole alkaloids, aplysinopsins, bisspiroimidazolidinones, chromenes, γ-pyrones, phenyl alkenes, naphthoquinones, and polyketides that possessed diversified bioactivities. This review provided an overview of the reported metabolites from Smenospongia sponges, including their biosynthesis, synthesis, and bioactivities in the period from 1980 to June 2022. The structural characteristics and diverse bioactivities of these metabolites could attract a great deal of attention from natural-product chemists and pharmaceuticals seeking to develop these metabolites into medicine for the treatment and prevention of certain health concerns. MDPI 2022-09-14 /pmc/articles/PMC9501515/ /pubmed/36144705 http://dx.doi.org/10.3390/molecules27185969 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ibrahim, Sabrin R. M. Fadil, Sana A. Fadil, Haifa A. Hareeri, Rawan H. Abdallah, Hossam M. Mohamed, Gamal A. Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities |
title | Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities |
title_full | Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities |
title_fullStr | Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities |
title_full_unstemmed | Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities |
title_short | Genus Smenospongia: Untapped Treasure of Biometabolites—Biosynthesis, Synthesis, and Bioactivities |
title_sort | genus smenospongia: untapped treasure of biometabolites—biosynthesis, synthesis, and bioactivities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501515/ https://www.ncbi.nlm.nih.gov/pubmed/36144705 http://dx.doi.org/10.3390/molecules27185969 |
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