Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach

We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed...

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Detalles Bibliográficos
Autores principales: Wyman, Kailey A., Girgis, Adel S., Surapaneni, Pragnakiran S., Moore, Jade M., Abo Shama, Noura M., Mahmoud, Sara H., Mostafa, Ahmed, Barghash, Reham F., Juan, Zou, Dobaria, Radha D., Almalki, Ahmad J., Ibrahim, Tarek S., Panda, Siva S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501548/
https://www.ncbi.nlm.nih.gov/pubmed/36144662
http://dx.doi.org/10.3390/molecules27185923
Descripción
Sumario:We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.

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