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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501548/ https://www.ncbi.nlm.nih.gov/pubmed/36144662 http://dx.doi.org/10.3390/molecules27185923 |
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| author | Wyman, Kailey A. Girgis, Adel S. Surapaneni, Pragnakiran S. Moore, Jade M. Abo Shama, Noura M. Mahmoud, Sara H. Mostafa, Ahmed Barghash, Reham F. Juan, Zou Dobaria, Radha D. Almalki, Ahmad J. Ibrahim, Tarek S. Panda, Siva S. |
| author_facet | Wyman, Kailey A. Girgis, Adel S. Surapaneni, Pragnakiran S. Moore, Jade M. Abo Shama, Noura M. Mahmoud, Sara H. Mostafa, Ahmed Barghash, Reham F. Juan, Zou Dobaria, Radha D. Almalki, Ahmad J. Ibrahim, Tarek S. Panda, Siva S. |
| author_sort | Wyman, Kailey A. |
| collection | PubMed |
| description | We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies. |
| format | Online Article Text |
| id | pubmed-9501548 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-95015482022-09-24 Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach Wyman, Kailey A. Girgis, Adel S. Surapaneni, Pragnakiran S. Moore, Jade M. Abo Shama, Noura M. Mahmoud, Sara H. Mostafa, Ahmed Barghash, Reham F. Juan, Zou Dobaria, Radha D. Almalki, Ahmad J. Ibrahim, Tarek S. Panda, Siva S. Molecules Article We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies. MDPI 2022-09-12 /pmc/articles/PMC9501548/ /pubmed/36144662 http://dx.doi.org/10.3390/molecules27185923 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Wyman, Kailey A. Girgis, Adel S. Surapaneni, Pragnakiran S. Moore, Jade M. Abo Shama, Noura M. Mahmoud, Sara H. Mostafa, Ahmed Barghash, Reham F. Juan, Zou Dobaria, Radha D. Almalki, Ahmad J. Ibrahim, Tarek S. Panda, Siva S. Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach |
| title | Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach |
| title_full | Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach |
| title_fullStr | Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach |
| title_full_unstemmed | Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach |
| title_short | Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach |
| title_sort | synthesis of potential antiviral agents for sars-cov-2 using molecular hybridization approach |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501548/ https://www.ncbi.nlm.nih.gov/pubmed/36144662 http://dx.doi.org/10.3390/molecules27185923 |
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