High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating

An all-fiber glucose sensor is proposed and demonstrated based on a helical intermediate-period fiber grating (HIPFG) produced by using a hydrogen/oxygen flame heating method. The HIPFG, with a grating length of 1.7 cm and a period of 35 μm, presents four sets of double dips with low insertion losses and strong coupling strengths in the transmission spectrum. The HIPFG possesses an averaged refractive index (RI) sensitivity of 213.6 nm/RIU nm/RIU in the RI range of 1.33–1.36 and a highest RI sensitivity of 472 nm/RIU at RI of 1.395. In addition, the HIPFG is demonstrated with a low-temperature sensitivity of 3.67 pm/°C, which promises a self-temperature compensation in glucose detection. In the glucose-sensing test, the HIPFG sensor manifests a detection sensitivity of 0.026 nm/(mg/mL) and a limit of detection (LOD) of 1 mg/mL. Moreover, the HIPFG sensor exhibits good stability in 2 h, indicating its capacity for long-time detection. The properties of easy fabrication, high flexibility, insensitivity to temperature, and good stability of the proposed HIPFG endow it with a promising potential for long-term and compact biosensors.