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High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating

An all-fiber glucose sensor is proposed and demonstrated based on a helical intermediate-period fiber grating (HIPFG) produced by using a hydrogen/oxygen flame heating method. The HIPFG, with a grating length of 1.7 cm and a period of 35 μm, presents four sets of double dips with low insertion losse...

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Detalles Bibliográficos
Autores principales: Zhong, Junlan, Liu, Shen, Zou, Tao, Yan, Wenqi, Chen, Peijing, Liu, Bonan, Sun, Zhongyuan, Wang, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501600/
https://www.ncbi.nlm.nih.gov/pubmed/36146172
http://dx.doi.org/10.3390/s22186824
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author Zhong, Junlan
Liu, Shen
Zou, Tao
Yan, Wenqi
Chen, Peijing
Liu, Bonan
Sun, Zhongyuan
Wang, Yiping
author_facet Zhong, Junlan
Liu, Shen
Zou, Tao
Yan, Wenqi
Chen, Peijing
Liu, Bonan
Sun, Zhongyuan
Wang, Yiping
author_sort Zhong, Junlan
collection PubMed
description An all-fiber glucose sensor is proposed and demonstrated based on a helical intermediate-period fiber grating (HIPFG) produced by using a hydrogen/oxygen flame heating method. The HIPFG, with a grating length of 1.7 cm and a period of 35 μm, presents four sets of double dips with low insertion losses and strong coupling strengths in the transmission spectrum. The HIPFG possesses an averaged refractive index (RI) sensitivity of 213.6 nm/RIU nm/RIU in the RI range of 1.33–1.36 and a highest RI sensitivity of 472 nm/RIU at RI of 1.395. In addition, the HIPFG is demonstrated with a low-temperature sensitivity of 3.67 pm/°C, which promises a self-temperature compensation in glucose detection. In the glucose-sensing test, the HIPFG sensor manifests a detection sensitivity of 0.026 nm/(mg/mL) and a limit of detection (LOD) of 1 mg/mL. Moreover, the HIPFG sensor exhibits good stability in 2 h, indicating its capacity for long-time detection. The properties of easy fabrication, high flexibility, insensitivity to temperature, and good stability of the proposed HIPFG endow it with a promising potential for long-term and compact biosensors.
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spelling pubmed-95016002022-09-24 High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating Zhong, Junlan Liu, Shen Zou, Tao Yan, Wenqi Chen, Peijing Liu, Bonan Sun, Zhongyuan Wang, Yiping Sensors (Basel) Communication An all-fiber glucose sensor is proposed and demonstrated based on a helical intermediate-period fiber grating (HIPFG) produced by using a hydrogen/oxygen flame heating method. The HIPFG, with a grating length of 1.7 cm and a period of 35 μm, presents four sets of double dips with low insertion losses and strong coupling strengths in the transmission spectrum. The HIPFG possesses an averaged refractive index (RI) sensitivity of 213.6 nm/RIU nm/RIU in the RI range of 1.33–1.36 and a highest RI sensitivity of 472 nm/RIU at RI of 1.395. In addition, the HIPFG is demonstrated with a low-temperature sensitivity of 3.67 pm/°C, which promises a self-temperature compensation in glucose detection. In the glucose-sensing test, the HIPFG sensor manifests a detection sensitivity of 0.026 nm/(mg/mL) and a limit of detection (LOD) of 1 mg/mL. Moreover, the HIPFG sensor exhibits good stability in 2 h, indicating its capacity for long-time detection. The properties of easy fabrication, high flexibility, insensitivity to temperature, and good stability of the proposed HIPFG endow it with a promising potential for long-term and compact biosensors. MDPI 2022-09-09 /pmc/articles/PMC9501600/ /pubmed/36146172 http://dx.doi.org/10.3390/s22186824 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Zhong, Junlan
Liu, Shen
Zou, Tao
Yan, Wenqi
Chen, Peijing
Liu, Bonan
Sun, Zhongyuan
Wang, Yiping
High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating
title High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating
title_full High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating
title_fullStr High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating
title_full_unstemmed High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating
title_short High-Sensitivity Optical Fiber-Based Glucose Sensor Using Helical Intermediate-Period Fiber Grating
title_sort high-sensitivity optical fiber-based glucose sensor using helical intermediate-period fiber grating
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501600/
https://www.ncbi.nlm.nih.gov/pubmed/36146172
http://dx.doi.org/10.3390/s22186824
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