Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria

PURPOSE: Janus kinase-1 (JAK1) tyrosine kinase mediates signaling from multiple cytokine receptors, including interferon alpha/beta and gamma (IFN-α/β and IFN-γ), which are important for viral and mycobacterial protection respectively. We previously reported autosomal recessive (AR) hypomorphic JAK1...

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Detalles Bibliográficos
Autores principales: Daza-Cajigal, Vanessa, Albuquerque, Adriana S., Young, Dan F., Ciancanelli, Michael J., Moulding, Dale, Angulo, Ivan, Jeanne-Julien, Valentine, Rosain, Jérémie, Minskaia, Ekaterina, Casanova, Jean-Laurent, Boisson-Dupuis, Stéphanie, Bustamante, Jacinta, Randall, Richard E., McHugh, Timothy D., Thrasher, Adrian J., Burns, Siobhan O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501714/
https://www.ncbi.nlm.nih.gov/pubmed/36159783
http://dx.doi.org/10.3389/fimmu.2022.888427

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