Focal Epilepsy in Individuals with Laron Syndrome

OBJECTIVE: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). METHODS: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. RESULTS: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of t...

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Autores principales: Goldberg, Lotem, Laron, Zvi, Kornreich, Liora, Scheuerman, Oded, Goldberg-Stern, Hadassa, Kraus, Dror
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501736/
https://www.ncbi.nlm.nih.gov/pubmed/35358968
http://dx.doi.org/10.1159/000524350
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author Goldberg, Lotem
Laron, Zvi
Kornreich, Liora
Scheuerman, Oded
Goldberg-Stern, Hadassa
Kraus, Dror
author_facet Goldberg, Lotem
Laron, Zvi
Kornreich, Liora
Scheuerman, Oded
Goldberg-Stern, Hadassa
Kraus, Dror
author_sort Goldberg, Lotem
collection PubMed
description OBJECTIVE: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). METHODS: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. RESULTS: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. CONCLUSION: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.
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spelling pubmed-95017362022-09-24 Focal Epilepsy in Individuals with Laron Syndrome Goldberg, Lotem Laron, Zvi Kornreich, Liora Scheuerman, Oded Goldberg-Stern, Hadassa Kraus, Dror Horm Res Paediatr Brief Report OBJECTIVE: The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). METHODS: Data were retrieved from medical records of a single-center cohort of 75 patients with LS. RESULTS: We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. CONCLUSION: Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood. S. Karger AG 2022-08 2022-03-31 /pmc/articles/PMC9501736/ /pubmed/35358968 http://dx.doi.org/10.1159/000524350 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
spellingShingle Brief Report
Goldberg, Lotem
Laron, Zvi
Kornreich, Liora
Scheuerman, Oded
Goldberg-Stern, Hadassa
Kraus, Dror
Focal Epilepsy in Individuals with Laron Syndrome
title Focal Epilepsy in Individuals with Laron Syndrome
title_full Focal Epilepsy in Individuals with Laron Syndrome
title_fullStr Focal Epilepsy in Individuals with Laron Syndrome
title_full_unstemmed Focal Epilepsy in Individuals with Laron Syndrome
title_short Focal Epilepsy in Individuals with Laron Syndrome
title_sort focal epilepsy in individuals with laron syndrome
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501736/
https://www.ncbi.nlm.nih.gov/pubmed/35358968
http://dx.doi.org/10.1159/000524350
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AT goldbergsternhadassa focalepilepsyinindividualswithlaronsyndrome
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