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Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry

Cholesterol-derived bile acids (BAs) affect numerous physiological functions such as glucose homeostasis, lipid metabolism and absorption, intestinal inflammation and immunity, as well as intestinal microbiota diversity. Diet influences the composition of the BA pool. In the present study, we analyz...

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Autores principales: Gagnon, William, Garneau, Véronique, Trottier, Jocelyn, Verreault, Mélanie, Couillard, Charles, Roy, Denis, Marette, André, Drouin-Chartier, Jean-Philippe, Vohl, Marie-Claude, Barbier, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501813/
https://www.ncbi.nlm.nih.gov/pubmed/36145234
http://dx.doi.org/10.3390/nu14183857
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author Gagnon, William
Garneau, Véronique
Trottier, Jocelyn
Verreault, Mélanie
Couillard, Charles
Roy, Denis
Marette, André
Drouin-Chartier, Jean-Philippe
Vohl, Marie-Claude
Barbier, Olivier
author_facet Gagnon, William
Garneau, Véronique
Trottier, Jocelyn
Verreault, Mélanie
Couillard, Charles
Roy, Denis
Marette, André
Drouin-Chartier, Jean-Philippe
Vohl, Marie-Claude
Barbier, Olivier
author_sort Gagnon, William
collection PubMed
description Cholesterol-derived bile acids (BAs) affect numerous physiological functions such as glucose homeostasis, lipid metabolism and absorption, intestinal inflammation and immunity, as well as intestinal microbiota diversity. Diet influences the composition of the BA pool. In the present study, we analyzed the impact of a dietary supplementation with a freeze-dried blueberry powder (BBP) on the fecal BA pool composition. The diet of 11 men and 13 women at risk of metabolic syndrome was supplemented with 50 g/day of BBP for 8 weeks, and feces were harvested before (pre) and after (post) BBP consumption. BAs were profiled using liquid chromatography coupled with tandem mass spectrometry. No significant changes in total BAs were detected when comparing pre- vs. post-BBP consumption samples. However, post-BBP consumption samples exhibited significant accumulations of glycine-conjugated BAs (p = 0.04), glycochenodeoxycholic (p = 0.01), and glycoursodeoxycholic (p = 0.01) acids, as well as a significant reduction (p = 0.03) in the secondary BA levels compared with pre-BBP feces. In conclusion, the fecal bileacidome is significantly altered after the consumption of BBP for 8 weeks. While additional studies are needed to fully understand the underlying mechanisms and physiological implications of these changes, our data suggest that the consumption of blueberries can modulate toxic BA elimination.
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spelling pubmed-95018132022-09-24 Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry Gagnon, William Garneau, Véronique Trottier, Jocelyn Verreault, Mélanie Couillard, Charles Roy, Denis Marette, André Drouin-Chartier, Jean-Philippe Vohl, Marie-Claude Barbier, Olivier Nutrients Article Cholesterol-derived bile acids (BAs) affect numerous physiological functions such as glucose homeostasis, lipid metabolism and absorption, intestinal inflammation and immunity, as well as intestinal microbiota diversity. Diet influences the composition of the BA pool. In the present study, we analyzed the impact of a dietary supplementation with a freeze-dried blueberry powder (BBP) on the fecal BA pool composition. The diet of 11 men and 13 women at risk of metabolic syndrome was supplemented with 50 g/day of BBP for 8 weeks, and feces were harvested before (pre) and after (post) BBP consumption. BAs were profiled using liquid chromatography coupled with tandem mass spectrometry. No significant changes in total BAs were detected when comparing pre- vs. post-BBP consumption samples. However, post-BBP consumption samples exhibited significant accumulations of glycine-conjugated BAs (p = 0.04), glycochenodeoxycholic (p = 0.01), and glycoursodeoxycholic (p = 0.01) acids, as well as a significant reduction (p = 0.03) in the secondary BA levels compared with pre-BBP feces. In conclusion, the fecal bileacidome is significantly altered after the consumption of BBP for 8 weeks. While additional studies are needed to fully understand the underlying mechanisms and physiological implications of these changes, our data suggest that the consumption of blueberries can modulate toxic BA elimination. MDPI 2022-09-17 /pmc/articles/PMC9501813/ /pubmed/36145234 http://dx.doi.org/10.3390/nu14183857 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gagnon, William
Garneau, Véronique
Trottier, Jocelyn
Verreault, Mélanie
Couillard, Charles
Roy, Denis
Marette, André
Drouin-Chartier, Jean-Philippe
Vohl, Marie-Claude
Barbier, Olivier
Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry
title Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry
title_full Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry
title_fullStr Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry
title_full_unstemmed Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry
title_short Impact of Blueberry Consumption on the Human Fecal Bileacidome: A Pilot Study of Bile Acid Modulation by Freeze-Dried Blueberry
title_sort impact of blueberry consumption on the human fecal bileacidome: a pilot study of bile acid modulation by freeze-dried blueberry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501813/
https://www.ncbi.nlm.nih.gov/pubmed/36145234
http://dx.doi.org/10.3390/nu14183857
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