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Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro
Both infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are the causative agents of acute and highly contagious diseases of juvenile salmonids, resulting in severe economic losses to these cold-water fish globally. There is an urgent need to explore antivi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501831/ https://www.ncbi.nlm.nih.gov/pubmed/36146887 http://dx.doi.org/10.3390/v14092080 |
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author | Ren, Guangming Xu, Liming Zhao, Jingzhuang Shao, Yizhi Lin, Yujie Li, Linfang Liu, Qi Lu, Tongyan Zhang, Qiya |
author_facet | Ren, Guangming Xu, Liming Zhao, Jingzhuang Shao, Yizhi Lin, Yujie Li, Linfang Liu, Qi Lu, Tongyan Zhang, Qiya |
author_sort | Ren, Guangming |
collection | PubMed |
description | Both infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are the causative agents of acute and highly contagious diseases of juvenile salmonids, resulting in severe economic losses to these cold-water fish globally. There is an urgent need to explore antiviral agents against IHNV and IPNV due to the lack of commercially available vaccines and antiviral drugs. More importantly, the co-infection of IHNV and IPNV is prevalent in nature, which not only aggravates extensive damage to the salmonids but also poses challenges to its prevention and control. The antiviral effects of a crude polysaccharide derived from seaweed (CSP) on IHNV and IPNV were evaluated in this study separately. Furthermore, the underlying antiviral mechanisms of CSP to IHNV and IPNV were analyzed, respectively. The results showed that CSP possessed excellent safety and good ability to inhibit IHNV, IPNV, and their co-infection. CSP preferred to act at the early stage of viral infection. The antiviral mechanism of CSP on IHNV is possibly involved in preventing viral attachment and release, while in IPNV, it is involved in suppressing viral attachment, entry, and release. Taken together, the results of this study shed new light on developing novel agents against viral infection in salmonid fish. |
format | Online Article Text |
id | pubmed-9501831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95018312022-09-24 Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro Ren, Guangming Xu, Liming Zhao, Jingzhuang Shao, Yizhi Lin, Yujie Li, Linfang Liu, Qi Lu, Tongyan Zhang, Qiya Viruses Article Both infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are the causative agents of acute and highly contagious diseases of juvenile salmonids, resulting in severe economic losses to these cold-water fish globally. There is an urgent need to explore antiviral agents against IHNV and IPNV due to the lack of commercially available vaccines and antiviral drugs. More importantly, the co-infection of IHNV and IPNV is prevalent in nature, which not only aggravates extensive damage to the salmonids but also poses challenges to its prevention and control. The antiviral effects of a crude polysaccharide derived from seaweed (CSP) on IHNV and IPNV were evaluated in this study separately. Furthermore, the underlying antiviral mechanisms of CSP to IHNV and IPNV were analyzed, respectively. The results showed that CSP possessed excellent safety and good ability to inhibit IHNV, IPNV, and their co-infection. CSP preferred to act at the early stage of viral infection. The antiviral mechanism of CSP on IHNV is possibly involved in preventing viral attachment and release, while in IPNV, it is involved in suppressing viral attachment, entry, and release. Taken together, the results of this study shed new light on developing novel agents against viral infection in salmonid fish. MDPI 2022-09-19 /pmc/articles/PMC9501831/ /pubmed/36146887 http://dx.doi.org/10.3390/v14092080 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ren, Guangming Xu, Liming Zhao, Jingzhuang Shao, Yizhi Lin, Yujie Li, Linfang Liu, Qi Lu, Tongyan Zhang, Qiya Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro |
title | Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro |
title_full | Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro |
title_fullStr | Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro |
title_full_unstemmed | Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro |
title_short | Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro |
title_sort | antiviral activity of crude polysaccharide derived from seaweed against ihnv and ipnv in vitro |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501831/ https://www.ncbi.nlm.nih.gov/pubmed/36146887 http://dx.doi.org/10.3390/v14092080 |
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