Cargando…

Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro

Both infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are the causative agents of acute and highly contagious diseases of juvenile salmonids, resulting in severe economic losses to these cold-water fish globally. There is an urgent need to explore antivi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Guangming, Xu, Liming, Zhao, Jingzhuang, Shao, Yizhi, Lin, Yujie, Li, Linfang, Liu, Qi, Lu, Tongyan, Zhang, Qiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501831/
https://www.ncbi.nlm.nih.gov/pubmed/36146887
http://dx.doi.org/10.3390/v14092080
_version_ 1784795564410404864
author Ren, Guangming
Xu, Liming
Zhao, Jingzhuang
Shao, Yizhi
Lin, Yujie
Li, Linfang
Liu, Qi
Lu, Tongyan
Zhang, Qiya
author_facet Ren, Guangming
Xu, Liming
Zhao, Jingzhuang
Shao, Yizhi
Lin, Yujie
Li, Linfang
Liu, Qi
Lu, Tongyan
Zhang, Qiya
author_sort Ren, Guangming
collection PubMed
description Both infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are the causative agents of acute and highly contagious diseases of juvenile salmonids, resulting in severe economic losses to these cold-water fish globally. There is an urgent need to explore antiviral agents against IHNV and IPNV due to the lack of commercially available vaccines and antiviral drugs. More importantly, the co-infection of IHNV and IPNV is prevalent in nature, which not only aggravates extensive damage to the salmonids but also poses challenges to its prevention and control. The antiviral effects of a crude polysaccharide derived from seaweed (CSP) on IHNV and IPNV were evaluated in this study separately. Furthermore, the underlying antiviral mechanisms of CSP to IHNV and IPNV were analyzed, respectively. The results showed that CSP possessed excellent safety and good ability to inhibit IHNV, IPNV, and their co-infection. CSP preferred to act at the early stage of viral infection. The antiviral mechanism of CSP on IHNV is possibly involved in preventing viral attachment and release, while in IPNV, it is involved in suppressing viral attachment, entry, and release. Taken together, the results of this study shed new light on developing novel agents against viral infection in salmonid fish.
format Online
Article
Text
id pubmed-9501831
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95018312022-09-24 Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro Ren, Guangming Xu, Liming Zhao, Jingzhuang Shao, Yizhi Lin, Yujie Li, Linfang Liu, Qi Lu, Tongyan Zhang, Qiya Viruses Article Both infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are the causative agents of acute and highly contagious diseases of juvenile salmonids, resulting in severe economic losses to these cold-water fish globally. There is an urgent need to explore antiviral agents against IHNV and IPNV due to the lack of commercially available vaccines and antiviral drugs. More importantly, the co-infection of IHNV and IPNV is prevalent in nature, which not only aggravates extensive damage to the salmonids but also poses challenges to its prevention and control. The antiviral effects of a crude polysaccharide derived from seaweed (CSP) on IHNV and IPNV were evaluated in this study separately. Furthermore, the underlying antiviral mechanisms of CSP to IHNV and IPNV were analyzed, respectively. The results showed that CSP possessed excellent safety and good ability to inhibit IHNV, IPNV, and their co-infection. CSP preferred to act at the early stage of viral infection. The antiviral mechanism of CSP on IHNV is possibly involved in preventing viral attachment and release, while in IPNV, it is involved in suppressing viral attachment, entry, and release. Taken together, the results of this study shed new light on developing novel agents against viral infection in salmonid fish. MDPI 2022-09-19 /pmc/articles/PMC9501831/ /pubmed/36146887 http://dx.doi.org/10.3390/v14092080 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ren, Guangming
Xu, Liming
Zhao, Jingzhuang
Shao, Yizhi
Lin, Yujie
Li, Linfang
Liu, Qi
Lu, Tongyan
Zhang, Qiya
Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro
title Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro
title_full Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro
title_fullStr Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro
title_full_unstemmed Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro
title_short Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro
title_sort antiviral activity of crude polysaccharide derived from seaweed against ihnv and ipnv in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9501831/
https://www.ncbi.nlm.nih.gov/pubmed/36146887
http://dx.doi.org/10.3390/v14092080
work_keys_str_mv AT renguangming antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro
AT xuliming antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro
AT zhaojingzhuang antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro
AT shaoyizhi antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro
AT linyujie antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro
AT lilinfang antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro
AT liuqi antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro
AT lutongyan antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro
AT zhangqiya antiviralactivityofcrudepolysaccharidederivedfromseaweedagainstihnvandipnvinvitro