Cargando…

Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder

Genetically informed drug development and repurposing is an attractive prospect for improving patient outcomes in psychiatry; however, the effectiveness of these endeavors is confounded by heterogeneity. We propose an approach that links interventions implicated by disorder-associated genetic risk,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reay, William R., Geaghan, Michael P., Atkins, Joshua R., Carr, Vaughan J., Green, Melissa J., Cairns, Murray J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502060/ https://www.ncbi.nlm.nih.gov/pubmed/36055211 http://dx.doi.org/10.1016/j.ajhg.2022.07.011

Ejemplares similares

Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders
por: Reay, William R., et al.
Publicado: (2022)

Pharmacological enrichment of polygenic risk for precision medicine in complex disorders
por: Reay, William R., et al.
Publicado: (2020)

Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype
por: Reay, William R., et al.
Publicado: (2018)

The MIR137 VNTR rs58335419 Is Associated With Cognitive Impairment in Schizophrenia and Altered Cortical Morphology
por: Mahmoudi, Ebrahim, et al.
Publicado: (2020)

F193. DYSREGULATION OF RETINOID SIGNALLING IN SCHIZOPHRENIA OBSERVED IN WHOLE GENOME SEQUENCE ANALYSIS
por: Reay, William, et al.
Publicado: (2018)

The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness
por: Reay, William R., et al.
Publicado: (2022)

Interactive effects of polygenic risk and cognitive subtype on brain morphology in schizophrenia spectrum and bipolar disorders
por: Quidé, Yann, et al.
Publicado: (2022)

miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease
por: Barnett, Michelle M., et al.
Publicado: (2023)

Investigation of glycaemic traits in psychiatric disorders using Mendelian randomisation revealed a causal relationship with anorexia nervosa
por: Adams, Danielle M., et al.
Publicado: (2020)

S194. INVESTIGATING PERIPHERAL MICRORNA-MRNA INTERACTIONS IN SCHIZOPHRENIA
por: Geaghan, Michael, et al.
Publicado: (2018)

The role of the retinoids in schizophrenia: genomic and clinical perspectives
por: Reay, William R., et al.
Publicado: (2019)

Perceptions of causal attribution and attitudes to genetic testing among people with schizophrenia and their first-degree relatives
por: Cullen, Melissa B. R., et al.
Publicado: (2022)

Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations
por: Reay, William R., et al.
Publicado: (2020)

Characterising the Transcriptional and Translational Impact of the Schizophrenia-Associated miR-1271-5p in Neuronal Cells
por: Kiltschewskij, Dylan J., et al.
Publicado: (2020)

Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: A support vector machine learning approach
por: Gould, Ian C., et al.
Publicado: (2014)

S188. DYSREGULATION OF CIRCULAR RNA EXPRESSION IN SCHIZOPHRENIA OBSERVED IN POSTMORTEM DORSOLATERAL PREFRONTAL CORTEX
por: Mahmoudi, Ebrahim, et al.
Publicado: (2018)

Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance
por: Greco, Laura A., et al.
Publicado: (2022)

Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia
por: Di Biase, Maria A., et al.
Publicado: (2022)

Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy
por: Kiltschewskij, Dylan J., et al.
Publicado: (2022)

Genetic overlap between autism, schizophrenia and bipolar disorder
por: Carroll, Liam S, et al.
Publicado: (2009)

Genetic assortative mating for schizophrenia and bipolar disorder
por: Jefsen, Oskar Hougaard, et al.
Publicado: (2022)

Genetic Liabilities Differentiating Bipolar Disorder, Schizophrenia, and Major Depressive Disorder, and Phenotypic Heterogeneity in Bipolar Disorder
por: Richards, Alexander L., et al.
Publicado: (2022)

Oxidative Stress Impact on the Transcriptome of Differentiating Neuroblastoma Cells: Implication for Psychiatric Disorders
por: Khavari, Behnaz, et al.
Publicado: (2020)

Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function
por: Reay, William R, et al.
Publicado: (2021)

DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review
por: Teroganova, Nina, et al.
Publicado: (2016)

The Genetic Variation of RELN Expression in Schizophrenia and Bipolar Disorder
por: Ovadia, Galit, et al.
Publicado: (2011)

Precision in bipolar disorders
por: Grande, I.
Publicado: (2023)

A Genetic Deconstruction of Neurocognitive Traits in Schizophrenia and Bipolar Disorder
por: Fernandes, Carla P. D., et al.
Publicado: (2013)

Transcriptome Sequencing Revealed Significant Alteration of Cortical Promoter Usage and Splicing in Schizophrenia
por: Wu, Jing Qin, et al.
Publicado: (2012)

Adaptive Associations between Social Cognition and Emotion Regulation are Absent in Schizophrenia and Bipolar Disorder
por: Rowland, Jesseca E., et al.
Publicado: (2013)

Lack of cortico-limbic coupling in bipolar disorder and schizophrenia during emotion regulation
por: Morris, R W, et al.
Publicado: (2012)

Increased Timing Variability in Schizophrenia and Bipolar Disorder
por: Bolbecker, Amanda R., et al.
Publicado: (2014)

HLA-E circulating and genetic determinants in schizophrenia and bipolar disorder
por: Boukouaci, Wahid, et al.
Publicado: (2021)

Editorial: Genetic Mechanisms of Biomarkers in Schizophrenia, Bipolar Disorder and Depression
por: Tang, Yiguo, et al.
Publicado: (2021)

Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
por: Gardiner, Erin J., et al.
Publicado: (2013)

Pareidolia in Schizophrenia and Bipolar Disorder
por: Abo Hamza, Eid G., et al.
Publicado: (2021)

Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses
por: Laurens, Kristin R., et al.
Publicado: (2015)

Multiomic prioritisation of risk genes for anorexia nervosa
por: Adams, Danielle M., et al.
Publicado: (2023)

Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking
por: Hindley, Guy, et al.
Publicado: (2021)

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder
por: Amann, B. L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lk7paooargvk57p9knda7kg9sv