Cargando…

Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols

Central nervous system (CNS) disorders, such as psychiatric disorders, neurodegeneration, chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would hugely benefit from specific and potent peptide pharmaceuticals and their low inherent toxicity. The delivery of peptide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alabsi, Wafaa, Eedara, Basanth Babu, Encinas-Basurto, David, Polt, Robin, Mansour, Heidi M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502087/ https://www.ncbi.nlm.nih.gov/pubmed/36145618 http://dx.doi.org/10.3390/pharmaceutics14091870

Ejemplares similares

Inhalation Delivery for the Treatment and Prevention of COVID-19 Infection
por: Eedara, Basanth Babu, et al.
Publicado: (2021)

Organic Solution Advanced Spray-Dried Microparticulate/Nanoparticulate Dry Powders of Lactomorphin for Respiratory Delivery: Physicochemical Characterization, In Vitro Aerosol Dispersion, and Cellular Studies
por: Alabsi, Wafaa, et al.
Publicado: (2020)

Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1—7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers
por: Alabsi, Wafaa, et al.
Publicado: (2021)

Comprehensive Physicochemical Characterization, In Vitro Membrane Permeation, and In Vitro Human Skin Cell Culture of a Novel TOPK Inhibitor, HI-TOPK-032
por: Eedara, Basanth Babu, et al.
Publicado: (2023)

Design, Physicochemical Characterization, and In Vitro Permeation of Innovative Resatorvid Topical Formulations for Targeted Skin Drug Delivery
por: Ruiz, Victor H., et al.
Publicado: (2022)

Innovative Rocuronium Bromide Topical Formulation for Targeted Skin Drug Delivery: Design, Comprehensive Characterization, In Vitro 2D/3D Human Cell Culture and Permeation
por: Ruiz, Victor H., et al.
Publicado: (2023)

Glycosylated Ang-(1-7) MasR Agonist Peptide Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles and Microparticles in Cognitive Impairment: Design, Particle Preparation, Physicochemical Characterization, and In Vitro Release
por: Encinas-Basurto, David, et al.
Publicado: (2022)

In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery
por: Maaz, Aida, et al.
Publicado: (2021)

Dissolution and Absorption of Inhaled Drug Particles in the Lungs
por: Eedara, Basanth Babu, et al.
Publicado: (2022)

Protein aerosol for intranasal nose to brain (N2B) delivery
por: Stützle, Martina, et al.
Publicado: (2015)

A STELLA simulation model for in vitro dissolution testing of respirable size particles
por: Eedara, Basanth Babu, et al.
Publicado: (2019)

Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation of Solid Dispersions: In Vitro and In Situ Evaluation
por: Eedara, Basanth Babu, et al.
Publicado: (2021)

Inhalable Combination Powder Formulations for Treating Latent and Multidrug-Resistant Tuberculosis: Formulation and In Vitro Characterization
por: Eedara, Basanth Babu, et al.
Publicado: (2023)

Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides
por: Lin, Tingting, et al.
Publicado: (2016)

Nose-to-Brain Delivery
por: Giunchedi, Paolo, et al.
Publicado: (2020)

The Upper Nasal Space: Option for Systemic Drug Delivery, Mucosal Vaccines and “Nose-to-Brain”
por: Shrewsbury, Stephen B.
Publicado: (2023)

Inhaled medical aerosols by nebulizer delivery in pulmonary hypertension
por: Mansour, Heidi M.
Publicado: (2018)

PNA6, a Lactosyl Analogue of Angiotensin-(1-7), Reverses Pain Induced in Murine Models of Inflammation, Chemotherapy-Induced Peripheral Neuropathy, and Metastatic Bone Disease
por: Sulaiman, Maha I., et al.
Publicado: (2023)

Cell-Penetrating Peptides as Valuable Tools for Nose-to-Brain Delivery of Biological Drugs
por: De Martini, Lisa Benedetta, et al.
Publicado: (2023)

Nanotechnological Advances for Nose to Brain Delivery of Therapeutics to Improve the Parkinson Therapy
por: Khatri, Dharmendra K., et al.
Publicado: (2023)

Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery
por: El Taweel, Mai M., et al.
Publicado: (2021)

A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies
por: Nižić Nodilo, Laura, et al.
Publicado: (2021)

A narrative review on trans-nasal pulmonary aerosol delivery
por: Li, Jie, et al.
Publicado: (2020)

Brain and Nasal Cavity Anatomy of the Cynomolgus Monkey: Species Differences from the Viewpoint of Direct Delivery from the Nose to the Brain
por: Sakane, Toshiyasu, et al.
Publicado: (2020)

Nanoemulsions for “Nose-to-Brain” Drug Delivery
por: Bonferoni, Maria Cristina, et al.
Publicado: (2019)

Inhalable PEGylated Phospholipid Nanocarriers and PEGylated Therapeutics for Respiratory Delivery as Aerosolized Colloidal Dispersions and Dry Powder Inhalers
por: Muralidharan, Priya, et al.
Publicado: (2014)

Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile
por: Perkušić, Mirna, et al.
Publicado: (2023)

Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers
por: Acosta, Maria F., et al.
Publicado: (2020)

Angiotensin-(1–7) Peptide Hormone Reduces Inflammation and Pathogen Burden during Mycoplasma pneumoniae Infection in Mice
por: Collins, Katie L., et al.
Publicado: (2021)

Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model—Protocol Development
por: Veronesi, Michael C., et al.
Publicado: (2021)

Evaluation of aerosol drug delivery with concurrent low- and high-flow nasal oxygen
por: Murphy, Barry, et al.
Publicado: (2022)

Systemic and brain delivery of antidiabetic peptides through nasal administration using cell-penetrating peptides
por: Maeng, Jeehye, et al.
Publicado: (2022)

Physicochemical characterization and aerosol dispersion performance of organic solution advanced spray-dried cyclosporine A multifunctional particles for dry powder inhalation aerosol delivery
por: Wu, Xiao, et al.
Publicado: (2013)

AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer’s and Parkinson’s Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery
por: Di Scala, Coralie, et al.
Publicado: (2022)

Acoustic Aerosol Delivery: Assessing of Various Nasal Delivery Techniques and Medical Devices on Intrasinus Drug Deposition
por: Leclerc, Lara, et al.
Publicado: (2023)

Design, Development, Physicochemical Characterization, and In Vitro Drug Release of Formoterol PEGylated PLGA Polymeric Nanoparticles
por: Vallorz, Ernest L., et al.
Publicado: (2022)

Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil
por: Espinoza, Lupe Carolina, et al.
Publicado: (2019)

Cachexia: Pathophysiology and Ghrelin Liposomes for Nose-to-Brain Delivery
por: T. de Barros, Cecilia, et al.
Publicado: (2020)

Microemulsion-Based Media in Nose-to-Brain Drug Delivery
por: Froelich, Anna, et al.
Publicado: (2021)

Non-Invasive Strategies for Nose-to-Brain Drug Delivery
por: Trevino, JT, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_87vobm8p74i3bioet7bvuo3egc