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Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate
Optical online methods are used to monitor the haemodialysis treatment efficiency of end stage kidney disease (ESKD) patients. The aim of this study was to analyse the effect of the administration of UV-absorbing drugs, such as paracetamol (Par), on the accuracy of optical monitoring the removal of...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502103/ https://www.ncbi.nlm.nih.gov/pubmed/36136548 http://dx.doi.org/10.3390/toxins14090610 |
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author | Adoberg, Annika Paats, Joosep Arund, Jürgen Dhondt, Annemieke Fridolin, Ivo Glorieux, Griet Holmar, Jana Lauri, Kai Leis, Liisi Luman, Merike Pilt, Kristjan Uhlin, Fredrik Tanner, Risto |
author_facet | Adoberg, Annika Paats, Joosep Arund, Jürgen Dhondt, Annemieke Fridolin, Ivo Glorieux, Griet Holmar, Jana Lauri, Kai Leis, Liisi Luman, Merike Pilt, Kristjan Uhlin, Fredrik Tanner, Risto |
author_sort | Adoberg, Annika |
collection | PubMed |
description | Optical online methods are used to monitor the haemodialysis treatment efficiency of end stage kidney disease (ESKD) patients. The aim of this study was to analyse the effect of the administration of UV-absorbing drugs, such as paracetamol (Par), on the accuracy of optical monitoring the removal of uremic toxins uric acid (UA) and indoxyl sulfate (IS) during standard haemodialysis (HD) and haemodiafiltration (HDF) treatments. Nine patients received Par in daily dosages 1–4 g for 30 sessions. For 137 sessions, in 36 patients the total daily dosage of UV-absorbing drugs was less than 500 mg, and for 6 sessions 3 patients received additional UV-absorbing drugs. Par administration slightly affected the accuracy of optically assessed removal of UA expressed as bias between optically and laboratory-assessed reduction ratios (RR) during HD but not HDF employing UV absorbance of spent dialysate (p < 0.05) at 295 nm wavelength with the strongest correlation between the concentration of UA and absorbance. Corresponding removal of IS based on fluorescence at Ex280/Em400 nm during HD and HDF was not affected. Administration of UV-absorbing drugs may in some settings influence the accuracy of optical assessments in spent dialysate of the removal of uremic solutes during haemodialysis treatment of ESKD patients. |
format | Online Article Text |
id | pubmed-9502103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95021032022-09-24 Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate Adoberg, Annika Paats, Joosep Arund, Jürgen Dhondt, Annemieke Fridolin, Ivo Glorieux, Griet Holmar, Jana Lauri, Kai Leis, Liisi Luman, Merike Pilt, Kristjan Uhlin, Fredrik Tanner, Risto Toxins (Basel) Article Optical online methods are used to monitor the haemodialysis treatment efficiency of end stage kidney disease (ESKD) patients. The aim of this study was to analyse the effect of the administration of UV-absorbing drugs, such as paracetamol (Par), on the accuracy of optical monitoring the removal of uremic toxins uric acid (UA) and indoxyl sulfate (IS) during standard haemodialysis (HD) and haemodiafiltration (HDF) treatments. Nine patients received Par in daily dosages 1–4 g for 30 sessions. For 137 sessions, in 36 patients the total daily dosage of UV-absorbing drugs was less than 500 mg, and for 6 sessions 3 patients received additional UV-absorbing drugs. Par administration slightly affected the accuracy of optically assessed removal of UA expressed as bias between optically and laboratory-assessed reduction ratios (RR) during HD but not HDF employing UV absorbance of spent dialysate (p < 0.05) at 295 nm wavelength with the strongest correlation between the concentration of UA and absorbance. Corresponding removal of IS based on fluorescence at Ex280/Em400 nm during HD and HDF was not affected. Administration of UV-absorbing drugs may in some settings influence the accuracy of optical assessments in spent dialysate of the removal of uremic solutes during haemodialysis treatment of ESKD patients. MDPI 2022-09-01 /pmc/articles/PMC9502103/ /pubmed/36136548 http://dx.doi.org/10.3390/toxins14090610 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Adoberg, Annika Paats, Joosep Arund, Jürgen Dhondt, Annemieke Fridolin, Ivo Glorieux, Griet Holmar, Jana Lauri, Kai Leis, Liisi Luman, Merike Pilt, Kristjan Uhlin, Fredrik Tanner, Risto Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate |
title | Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate |
title_full | Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate |
title_fullStr | Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate |
title_full_unstemmed | Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate |
title_short | Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate |
title_sort | treatment with paracetamol can interfere with the intradialytic optical estimation in spent dialysate of uric acid but not of indoxyl sulfate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502103/ https://www.ncbi.nlm.nih.gov/pubmed/36136548 http://dx.doi.org/10.3390/toxins14090610 |
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