Cargando…

Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study

The volume and distribution of fluids available in the gastrointestinal (GI) tract may substantially affect oral drug absorption. Magnetic resonance imaging (MRI) has been used in the past to quantify these fluid volumes in adults and its use is now being extended to the pediatric population. The pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Van der Veken, Matthias, Aertsen, Michael, Brouwers, Joachim, Stillhart, Cordula, Parrott, Neil, Augustijns, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502126/
https://www.ncbi.nlm.nih.gov/pubmed/36145683
http://dx.doi.org/10.3390/pharmaceutics14091935
_version_ 1784795630374223872
author Van der Veken, Matthias
Aertsen, Michael
Brouwers, Joachim
Stillhart, Cordula
Parrott, Neil
Augustijns, Patrick
author_facet Van der Veken, Matthias
Aertsen, Michael
Brouwers, Joachim
Stillhart, Cordula
Parrott, Neil
Augustijns, Patrick
author_sort Van der Veken, Matthias
collection PubMed
description The volume and distribution of fluids available in the gastrointestinal (GI) tract may substantially affect oral drug absorption. Magnetic resonance imaging (MRI) has been used in the past to quantify these fluid volumes in adults and its use is now being extended to the pediatric population. The present research pursued a retrospective, explorative analysis of existing clinical MRI data generated for pediatric patients. Images of 140 children from all pediatric subpopulations were analyzed for their resting GI fluid volumes in fasting conditions. In general, an increase in fluid volume as a function of age was observed for the stomach, duodenum, jejunum, and small intestine (SI) as a whole. No specific pattern was observed for the ileum and colon. Body mass index (BMI), body weight, body height, and SI length were evaluated as easy-to-measure clinical estimators of the gastric and SI fluid volumes. Although weight and height were identified as the best estimators, none performed ideally based on the coefficient of determination (R(2)). Data generated in this study can be used as physiologically relevant input for biorelevant in vitro tests and in silico models tailored to the pediatric population, thereby contributing to the efficient development of successful oral drug products for children.
format Online
Article
Text
id pubmed-9502126
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95021262022-09-24 Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study Van der Veken, Matthias Aertsen, Michael Brouwers, Joachim Stillhart, Cordula Parrott, Neil Augustijns, Patrick Pharmaceutics Article The volume and distribution of fluids available in the gastrointestinal (GI) tract may substantially affect oral drug absorption. Magnetic resonance imaging (MRI) has been used in the past to quantify these fluid volumes in adults and its use is now being extended to the pediatric population. The present research pursued a retrospective, explorative analysis of existing clinical MRI data generated for pediatric patients. Images of 140 children from all pediatric subpopulations were analyzed for their resting GI fluid volumes in fasting conditions. In general, an increase in fluid volume as a function of age was observed for the stomach, duodenum, jejunum, and small intestine (SI) as a whole. No specific pattern was observed for the ileum and colon. Body mass index (BMI), body weight, body height, and SI length were evaluated as easy-to-measure clinical estimators of the gastric and SI fluid volumes. Although weight and height were identified as the best estimators, none performed ideally based on the coefficient of determination (R(2)). Data generated in this study can be used as physiologically relevant input for biorelevant in vitro tests and in silico models tailored to the pediatric population, thereby contributing to the efficient development of successful oral drug products for children. MDPI 2022-09-13 /pmc/articles/PMC9502126/ /pubmed/36145683 http://dx.doi.org/10.3390/pharmaceutics14091935 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Van der Veken, Matthias
Aertsen, Michael
Brouwers, Joachim
Stillhart, Cordula
Parrott, Neil
Augustijns, Patrick
Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study
title Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study
title_full Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study
title_fullStr Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study
title_full_unstemmed Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study
title_short Gastrointestinal Fluid Volumes in Pediatrics: A Retrospective MRI Study
title_sort gastrointestinal fluid volumes in pediatrics: a retrospective mri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502126/
https://www.ncbi.nlm.nih.gov/pubmed/36145683
http://dx.doi.org/10.3390/pharmaceutics14091935
work_keys_str_mv AT vandervekenmatthias gastrointestinalfluidvolumesinpediatricsaretrospectivemristudy
AT aertsenmichael gastrointestinalfluidvolumesinpediatricsaretrospectivemristudy
AT brouwersjoachim gastrointestinalfluidvolumesinpediatricsaretrospectivemristudy
AT stillhartcordula gastrointestinalfluidvolumesinpediatricsaretrospectivemristudy
AT parrottneil gastrointestinalfluidvolumesinpediatricsaretrospectivemristudy
AT augustijnspatrick gastrointestinalfluidvolumesinpediatricsaretrospectivemristudy