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Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients

(1) Background: Type 2 diabetes mellitus (T2DM) contributes to cardiovascular disease and related mortality through the insidious effects of insulin resistance and chronic inflammation. Mitral annular calcification (MAC) is one such degenerative process promoted by T2DM. (2) Methods: This is a post...

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Autores principales: Grigorescu, Elena-Daniela, Lăcătușu, Cristina-Mihaela, Floria, Mariana, Cazac, Georgiana-Diana, Onofriescu, Alina, Ceasovschih, Alexandr, Crețu, Ioana, Mihai, Bogdan-Mircea, Șorodoc, Laurențiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502175/
https://www.ncbi.nlm.nih.gov/pubmed/36143268
http://dx.doi.org/10.3390/jpm12091484
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author Grigorescu, Elena-Daniela
Lăcătușu, Cristina-Mihaela
Floria, Mariana
Cazac, Georgiana-Diana
Onofriescu, Alina
Ceasovschih, Alexandr
Crețu, Ioana
Mihai, Bogdan-Mircea
Șorodoc, Laurențiu
author_facet Grigorescu, Elena-Daniela
Lăcătușu, Cristina-Mihaela
Floria, Mariana
Cazac, Georgiana-Diana
Onofriescu, Alina
Ceasovschih, Alexandr
Crețu, Ioana
Mihai, Bogdan-Mircea
Șorodoc, Laurențiu
author_sort Grigorescu, Elena-Daniela
collection PubMed
description (1) Background: Type 2 diabetes mellitus (T2DM) contributes to cardiovascular disease and related mortality through the insidious effects of insulin resistance and chronic inflammation. Mitral annular calcification (MAC) is one such degenerative process promoted by T2DM. (2) Methods: This is a post hoc analysis of insulin resistance, inflammation, and hepatic steatosis markers in T2DM patients without atherosclerotic manifestations, but with incidental echocardiographic detection of mild MAC. (3) Results: 138 consenting patients were 49.3% men, 57.86 years old, with a history of T2DM of 6.16 years and HbA(1c) 8.06%, of whom sixty had mild MAC (43.47%). The statistically significant differences between patients with/without MAC were higher HOMA C-peptide and C-peptide index for insulin resistance, higher TNF-α for inflammation, and lower estimated glomerular filtration rate. High-sensitive C-reactive protein (hsCRP) was significantly associated with insulin resistance and the strength of the relationship was higher in the MAC group. Predictive of MAC were TNF-α, HOMA C-peptide, and especially hepatic steatosis and hypertension. (4) Conclusions: MAC was more prevalent than reported in the literature. Insulin resistance and inflammation were predictive of MAC, but significant markers differ across studies. Widely available routine tests and echocardiographic assessments are useful in the early identification of mitral annular calcifications in diabetes patients.
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spelling pubmed-95021752022-09-24 Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients Grigorescu, Elena-Daniela Lăcătușu, Cristina-Mihaela Floria, Mariana Cazac, Georgiana-Diana Onofriescu, Alina Ceasovschih, Alexandr Crețu, Ioana Mihai, Bogdan-Mircea Șorodoc, Laurențiu J Pers Med Article (1) Background: Type 2 diabetes mellitus (T2DM) contributes to cardiovascular disease and related mortality through the insidious effects of insulin resistance and chronic inflammation. Mitral annular calcification (MAC) is one such degenerative process promoted by T2DM. (2) Methods: This is a post hoc analysis of insulin resistance, inflammation, and hepatic steatosis markers in T2DM patients without atherosclerotic manifestations, but with incidental echocardiographic detection of mild MAC. (3) Results: 138 consenting patients were 49.3% men, 57.86 years old, with a history of T2DM of 6.16 years and HbA(1c) 8.06%, of whom sixty had mild MAC (43.47%). The statistically significant differences between patients with/without MAC were higher HOMA C-peptide and C-peptide index for insulin resistance, higher TNF-α for inflammation, and lower estimated glomerular filtration rate. High-sensitive C-reactive protein (hsCRP) was significantly associated with insulin resistance and the strength of the relationship was higher in the MAC group. Predictive of MAC were TNF-α, HOMA C-peptide, and especially hepatic steatosis and hypertension. (4) Conclusions: MAC was more prevalent than reported in the literature. Insulin resistance and inflammation were predictive of MAC, but significant markers differ across studies. Widely available routine tests and echocardiographic assessments are useful in the early identification of mitral annular calcifications in diabetes patients. MDPI 2022-09-10 /pmc/articles/PMC9502175/ /pubmed/36143268 http://dx.doi.org/10.3390/jpm12091484 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Grigorescu, Elena-Daniela
Lăcătușu, Cristina-Mihaela
Floria, Mariana
Cazac, Georgiana-Diana
Onofriescu, Alina
Ceasovschih, Alexandr
Crețu, Ioana
Mihai, Bogdan-Mircea
Șorodoc, Laurențiu
Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients
title Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients
title_full Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients
title_fullStr Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients
title_full_unstemmed Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients
title_short Association of Inflammatory and Metabolic Biomarkers with Mitral Annular Calcification in Type 2 Diabetes Patients
title_sort association of inflammatory and metabolic biomarkers with mitral annular calcification in type 2 diabetes patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502175/
https://www.ncbi.nlm.nih.gov/pubmed/36143268
http://dx.doi.org/10.3390/jpm12091484
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