Cargando…

Identification of MHC-I-Presented Porcine Respiratory and Reproductive Syndrome Virus (PRRSV) Peptides Reveals Immunogenic Epitopes within Several Non-Structural Proteins Recognized by CD8(+) T Cells

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most relevant porcine pathogens worldwide. Active control of the disease relies on modified live virus vaccines (MLVs), as most inactivated vaccines provide very limited protection. Neutralizing antibodies occur late in infect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mötz, Marlene, Stas, Melissa R., Hammer, Sabine E., Duckova, Tereza, Fontaine, Frederic, Kiesler, Alexandra, Seitz, Kerstin, Ladinig, Andrea, Müller, André C., Riedel, Christiane, Saalmüller, Armin, Rümenapf, Till
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502253/ https://www.ncbi.nlm.nih.gov/pubmed/36146698 http://dx.doi.org/10.3390/v14091891

Ejemplares similares

Prevalence of Linda Virus Neutralizing Antibodies in the Austrian Pig Population
por: Kiesler, Alexandra, et al.
Publicado: (2021)

A Conserved Stem-Loop Structure within ORF5 Is a Frequent Recombination Hotspot for Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) with a Particular Modified Live Virus (MLV) Strain
por: Mötz, Marlene, et al.
Publicado: (2023)

Influence of PRRSV-1 vaccination and infection on mononuclear immune cells at the maternal-fetal interface
por: Stas, Melissa R., et al.
Publicado: (2022)

Gene expression of peripheral blood mononuclear cells and CD8(+) T cells from gilts after PRRSV infection
por: Lagumdzic, Emil, et al.
Publicado: (2023)

New Emergence of the Novel Pestivirus Linda Virus in a Pig Farm in Carinthia, Austria
por: Kiesler, Alexandra, et al.
Publicado: (2022)

Influence of deoxynivalenol-contaminated feed on the immune response of pigs after PRRSV vaccination and infection
por: Pierron, Alix, et al.
Publicado: (2023)

Phenotypic Characterization of a Virulent PRRSV-1 Isolate in a Reproductive Model With and Without Prior Heterologous Modified Live PRRSV-1 Vaccination
por: Kreutzmann, Heinrich, et al.
Publicado: (2022)

Clinical and Serological Evaluation of LINDA Virus Infections in Post-Weaning Piglets
por: Kiesler, Alexandra, et al.
Publicado: (2019)

Vaccine-induced antibodies linked to bovine neonatal pancytopenia (BNP) recognize cattle major histocompatibility complex class I (MHC I)
por: Deutskens, Fabian, et al.
Publicado: (2011)

Discovery of a phylogenetically distinct poxvirus in diseased Crocodilurus amazonicus (family Teiidae)
por: Seitz, Kerstin, et al.
Publicado: (2021)

In Situ Hybridization of PRRSV-1 Combined with Digital Image Analysis in Lung Tissues of Pigs Challenged with PRRSV-1
por: Dénes, Lilla, et al.
Publicado: (2021)

PRRSV-infected monocyte-derived dendritic cells express high levels of SLA-DR and CD80/86 but do not stimulate PRRSV-naïve regulatory T cells to proliferate
por: Rodríguez-Gómez, Irene M, et al.
Publicado: (2015)

Emergence of a virulent porcine reproductive and respiratory syndrome virus (PRRSV) 1 strain in Lower Austria
por: Sinn, Leonie J, et al.
Publicado: (2016)

Use of Three Air Samplers for the Detection of PRRSV-1 under Experimental and Field Conditions
por: Stein, Heiko, et al.
Publicado: (2018)

Quantitative Analysis of Inflammatory Uterine Lesions of Pregnant Gilts with Digital Image Analysis Following Experimental PRRSV-1 Infection
por: Horváth, Dávid G., et al.
Publicado: (2023)

Characterization of two Austrian porcine reproductive and respiratory syndrome virus (PRRSV) field isolates reveals relationship to East Asian strains
por: Sinn, Leonie J., et al.
Publicado: (2016)

ADAM17 Is an Essential Factor for the Infection of Bovine Cells with Pestiviruses
por: Zaruba, Marianne, et al.
Publicado: (2022)

A Highly Effective System for Predicting MHC-II Epitopes With Immunogenicity
por: Xu, Shi, et al.
Publicado: (2022)

Unique Epitopes Recognized by Monoclonal Antibodies against HP-PRRSV: Deep Understanding of Antigenic Structure and Virus-Antibody Interaction
por: Wang, Qian, et al.
Publicado: (2014)

An immunodominant epitope present in multiple class I MHC molecules and recognized by cytotoxic T lymphocytes
Publicado: (1988)

Production and Evaluation of Virus-Like Particles Displaying Immunogenic Epitopes of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
por: Murthy, Ambika Mosale Venkatesh, et al.
Publicado: (2015)

Computational mining of MHC class II epitopes for the development of universal immunogenic proteins
por: Saylor, Kyle, et al.
Publicado: (2022)

Novel Pestivirus Species in Pigs, Austria, 2015
por: Lamp, Benjamin, et al.
Publicado: (2017)

Efficacy of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Vaccine against Experimental Infection with PRRSV AUT15-33 in Weaned Piglets
por: Duerlinger, Sophie, et al.
Publicado: (2022)

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
por: Tynan, Fleur E., et al.
Publicado: (2005)

Progression of asexual to sexual stages of Cystoisospora suis in a host cell-free environment as a model for Coccidia
por: Feix, Anna Sophia, et al.
Publicado: (2021)

TDP-43 and HERV-K Envelope-Specific Immunogenic Epitopes Are Recognized in ALS Patients
por: Simula, Elena Rita, et al.
Publicado: (2021)

Atypical Porcine Pestiviruses: Relationships and Conserved Structural Features
por: Riedel, Christiane, et al.
Publicado: (2021)

The core protein of a pestivirus protects the incoming virus against IFN-induced effectors
por: Riedel, Christiane, et al.
Publicado: (2017)

Evaluating the Immunogenicity of Protein Drugs by Applying In Vitro MHC Binding Data and the Immune Epitope Database and Analysis Resource
por: Paul, Sinu, et al.
Publicado: (2013)

Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes
Publicado: (1996)

Fluorophore labelled BVDV: a novel tool for the analysis of infection dynamics
por: Riedel, Christiane, et al.
Publicado: (2019)

Congenital infection with atypical porcine pestivirus (APPV) is associated with disease and viral persistence
por: Schwarz, Lukas, et al.
Publicado: (2017)

Epitopes associated with MHC restriction site of T cells. III. I-J epitope on MHC-restricted T helper cells
Publicado: (1987)

Epitope mapping and characterization of a novel Nsp10-specific monoclonal antibody that differentiates genotype 2 PRRSV from genotype 1 PRRSV
por: Zhang, Zhibang, et al.
Publicado: (2017)

NK and T Cell Differentiation at the Maternal-Fetal Interface in Sows During Late Gestation
por: Stas, Melissa R., et al.
Publicado: (2020)

Construction and Rescue of a Molecular Clone of Deformed Wing Virus (DWV)
por: Lamp, Benjamin, et al.
Publicado: (2016)

Porcine Circoviruses and Herpesviruses Are Prevalent in an Austrian Game Population
por: Auer, Angelika, et al.
Publicado: (2022)

Prediction and in vitro verification of potential CTL epitopes conserved among PRRSV-2 strains
por: Welner, Simon, et al.
Publicado: (2017)

Cryo EM structure of the rabies virus ribonucleoprotein complex
por: Riedel, Christiane, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6tlu402bp4r8i7d7f92k7gat0p