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Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division

The journey from a single fertilised cell to a multicellular organism is, at the most fundamental level, orchestrated by mitotic cell divisions. Both the rate and the orientation of cell divisions are important in ensuring the proper development of an embryo. Simultaneous with cell proliferation, em...

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Detalles Bibliográficos
Autores principales: Tarannum, Nawseen, Singh, Rohan, Woolner, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502278/
https://www.ncbi.nlm.nih.gov/pubmed/36135370
http://dx.doi.org/10.3390/jdb10030037
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author Tarannum, Nawseen
Singh, Rohan
Woolner, Sarah
author_facet Tarannum, Nawseen
Singh, Rohan
Woolner, Sarah
author_sort Tarannum, Nawseen
collection PubMed
description The journey from a single fertilised cell to a multicellular organism is, at the most fundamental level, orchestrated by mitotic cell divisions. Both the rate and the orientation of cell divisions are important in ensuring the proper development of an embryo. Simultaneous with cell proliferation, embryonic cells constantly experience a wide range of mechanical forces from their surrounding tissue environment. Cells must be able to read and respond correctly to these forces since they are known to affect a multitude of biological functions, including cell divisions. The interplay between the mechanical environment and cell divisions is particularly crucial during embryogenesis when tissues undergo dynamic changes in their shape, architecture, and overall organisation to generate functional tissues and organs. Here we review our current understanding of the cellular mechanisms by which mechanical force regulates cell division and place this knowledge within the context of embryogenesis and tissue morphogenesis.
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spelling pubmed-95022782022-09-24 Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division Tarannum, Nawseen Singh, Rohan Woolner, Sarah J Dev Biol Review The journey from a single fertilised cell to a multicellular organism is, at the most fundamental level, orchestrated by mitotic cell divisions. Both the rate and the orientation of cell divisions are important in ensuring the proper development of an embryo. Simultaneous with cell proliferation, embryonic cells constantly experience a wide range of mechanical forces from their surrounding tissue environment. Cells must be able to read and respond correctly to these forces since they are known to affect a multitude of biological functions, including cell divisions. The interplay between the mechanical environment and cell divisions is particularly crucial during embryogenesis when tissues undergo dynamic changes in their shape, architecture, and overall organisation to generate functional tissues and organs. Here we review our current understanding of the cellular mechanisms by which mechanical force regulates cell division and place this knowledge within the context of embryogenesis and tissue morphogenesis. MDPI 2022-09-01 /pmc/articles/PMC9502278/ /pubmed/36135370 http://dx.doi.org/10.3390/jdb10030037 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tarannum, Nawseen
Singh, Rohan
Woolner, Sarah
Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division
title Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division
title_full Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division
title_fullStr Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division
title_full_unstemmed Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division
title_short Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division
title_sort sculpting an embryo: the interplay between mechanical force and cell division
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502278/
https://www.ncbi.nlm.nih.gov/pubmed/36135370
http://dx.doi.org/10.3390/jdb10030037
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