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Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division
The journey from a single fertilised cell to a multicellular organism is, at the most fundamental level, orchestrated by mitotic cell divisions. Both the rate and the orientation of cell divisions are important in ensuring the proper development of an embryo. Simultaneous with cell proliferation, em...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502278/ https://www.ncbi.nlm.nih.gov/pubmed/36135370 http://dx.doi.org/10.3390/jdb10030037 |
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author | Tarannum, Nawseen Singh, Rohan Woolner, Sarah |
author_facet | Tarannum, Nawseen Singh, Rohan Woolner, Sarah |
author_sort | Tarannum, Nawseen |
collection | PubMed |
description | The journey from a single fertilised cell to a multicellular organism is, at the most fundamental level, orchestrated by mitotic cell divisions. Both the rate and the orientation of cell divisions are important in ensuring the proper development of an embryo. Simultaneous with cell proliferation, embryonic cells constantly experience a wide range of mechanical forces from their surrounding tissue environment. Cells must be able to read and respond correctly to these forces since they are known to affect a multitude of biological functions, including cell divisions. The interplay between the mechanical environment and cell divisions is particularly crucial during embryogenesis when tissues undergo dynamic changes in their shape, architecture, and overall organisation to generate functional tissues and organs. Here we review our current understanding of the cellular mechanisms by which mechanical force regulates cell division and place this knowledge within the context of embryogenesis and tissue morphogenesis. |
format | Online Article Text |
id | pubmed-9502278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95022782022-09-24 Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division Tarannum, Nawseen Singh, Rohan Woolner, Sarah J Dev Biol Review The journey from a single fertilised cell to a multicellular organism is, at the most fundamental level, orchestrated by mitotic cell divisions. Both the rate and the orientation of cell divisions are important in ensuring the proper development of an embryo. Simultaneous with cell proliferation, embryonic cells constantly experience a wide range of mechanical forces from their surrounding tissue environment. Cells must be able to read and respond correctly to these forces since they are known to affect a multitude of biological functions, including cell divisions. The interplay between the mechanical environment and cell divisions is particularly crucial during embryogenesis when tissues undergo dynamic changes in their shape, architecture, and overall organisation to generate functional tissues and organs. Here we review our current understanding of the cellular mechanisms by which mechanical force regulates cell division and place this knowledge within the context of embryogenesis and tissue morphogenesis. MDPI 2022-09-01 /pmc/articles/PMC9502278/ /pubmed/36135370 http://dx.doi.org/10.3390/jdb10030037 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tarannum, Nawseen Singh, Rohan Woolner, Sarah Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division |
title | Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division |
title_full | Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division |
title_fullStr | Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division |
title_full_unstemmed | Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division |
title_short | Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division |
title_sort | sculpting an embryo: the interplay between mechanical force and cell division |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502278/ https://www.ncbi.nlm.nih.gov/pubmed/36135370 http://dx.doi.org/10.3390/jdb10030037 |
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