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Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study

The reported cases of pertussis vary considerably globally. In the present nationwide study, we aimed to record the Bordetella pertussis prevalence in Greece by measuring serum IgG specific antibody levels to pertussis toxin (anti-PT IgG). General practitioners and laboratories participated in this...

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Autores principales: Papagiannis, Dimitrios, Thireos, Eleftherios, Mariolis, Anargiros, Katsioulis, Antonios, Gartzonika, Konstantina, Malliaraki, Niki, Agnantis, Christos, Tsaras, Konstantinos, Malli, Foteini, Rouka, Erasmia C., Tsiaousi, Ioanna, Symvoulakis, Emmanouil K., Rachiotis, Georgios, Gourgoulianis, Konstantinos I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502282/
https://www.ncbi.nlm.nih.gov/pubmed/36146589
http://dx.doi.org/10.3390/vaccines10091511
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author Papagiannis, Dimitrios
Thireos, Eleftherios
Mariolis, Anargiros
Katsioulis, Antonios
Gartzonika, Konstantina
Malliaraki, Niki
Agnantis, Christos
Tsaras, Konstantinos
Malli, Foteini
Rouka, Erasmia C.
Tsiaousi, Ioanna
Symvoulakis, Emmanouil K.
Rachiotis, Georgios
Gourgoulianis, Konstantinos I.
author_facet Papagiannis, Dimitrios
Thireos, Eleftherios
Mariolis, Anargiros
Katsioulis, Antonios
Gartzonika, Konstantina
Malliaraki, Niki
Agnantis, Christos
Tsaras, Konstantinos
Malli, Foteini
Rouka, Erasmia C.
Tsiaousi, Ioanna
Symvoulakis, Emmanouil K.
Rachiotis, Georgios
Gourgoulianis, Konstantinos I.
author_sort Papagiannis, Dimitrios
collection PubMed
description The reported cases of pertussis vary considerably globally. In the present nationwide study, we aimed to record the Bordetella pertussis prevalence in Greece by measuring serum IgG specific antibody levels to pertussis toxin (anti-PT IgG). General practitioners and laboratories participated in this study from 12 regions of Greece. A geographically stratified sampling plan based on regional units (NUTS level 2) was applied in order to produce a representative sample, taking into consideration age group (30–39, 40–49, 50–59, 60–69, 70–79 and 80+) and sex. In total, 1169 subjects participated in the study. The percentage of participants with anti-PT IgG antibodies higher than 50 IU/mL was 3.7%. The levels of anti-PT IgG antibodies of total sample ranged between 1.46 IU/mL to 126.60 IU/mL, with mean 17.74 IU/mL and standard deviation 14.03 U/mL (p-value < 0.001). The total seroprevalence of Greek regions for pertussis disease varied significantly among prefectures. The region with the highest seroprevalence was Peloponnese 21.3%, followed by the region of Central Greece 15.3%. The proportion of adults who have pertussis specific antibodies <50 IU/mL has been >90%, suggesting that a large number of adults may be vulnerable to infection of pertussis despite well-established vaccination programs in Greece. Despite the fact that vaccination reduced the number of reported pertussis cases in the last decades in Greece, our seroprevalence study may indicate that the herd immunity level among Greek adults is suboptimal.
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spelling pubmed-95022822022-09-24 Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study Papagiannis, Dimitrios Thireos, Eleftherios Mariolis, Anargiros Katsioulis, Antonios Gartzonika, Konstantina Malliaraki, Niki Agnantis, Christos Tsaras, Konstantinos Malli, Foteini Rouka, Erasmia C. Tsiaousi, Ioanna Symvoulakis, Emmanouil K. Rachiotis, Georgios Gourgoulianis, Konstantinos I. Vaccines (Basel) Article The reported cases of pertussis vary considerably globally. In the present nationwide study, we aimed to record the Bordetella pertussis prevalence in Greece by measuring serum IgG specific antibody levels to pertussis toxin (anti-PT IgG). General practitioners and laboratories participated in this study from 12 regions of Greece. A geographically stratified sampling plan based on regional units (NUTS level 2) was applied in order to produce a representative sample, taking into consideration age group (30–39, 40–49, 50–59, 60–69, 70–79 and 80+) and sex. In total, 1169 subjects participated in the study. The percentage of participants with anti-PT IgG antibodies higher than 50 IU/mL was 3.7%. The levels of anti-PT IgG antibodies of total sample ranged between 1.46 IU/mL to 126.60 IU/mL, with mean 17.74 IU/mL and standard deviation 14.03 U/mL (p-value < 0.001). The total seroprevalence of Greek regions for pertussis disease varied significantly among prefectures. The region with the highest seroprevalence was Peloponnese 21.3%, followed by the region of Central Greece 15.3%. The proportion of adults who have pertussis specific antibodies <50 IU/mL has been >90%, suggesting that a large number of adults may be vulnerable to infection of pertussis despite well-established vaccination programs in Greece. Despite the fact that vaccination reduced the number of reported pertussis cases in the last decades in Greece, our seroprevalence study may indicate that the herd immunity level among Greek adults is suboptimal. MDPI 2022-09-09 /pmc/articles/PMC9502282/ /pubmed/36146589 http://dx.doi.org/10.3390/vaccines10091511 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Papagiannis, Dimitrios
Thireos, Eleftherios
Mariolis, Anargiros
Katsioulis, Antonios
Gartzonika, Konstantina
Malliaraki, Niki
Agnantis, Christos
Tsaras, Konstantinos
Malli, Foteini
Rouka, Erasmia C.
Tsiaousi, Ioanna
Symvoulakis, Emmanouil K.
Rachiotis, Georgios
Gourgoulianis, Konstantinos I.
Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study
title Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study
title_full Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study
title_fullStr Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study
title_full_unstemmed Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study
title_short Pertussis Prevalence in Adult Population in Greece: A Seroprevalence Nationwide Study
title_sort pertussis prevalence in adult population in greece: a seroprevalence nationwide study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502282/
https://www.ncbi.nlm.nih.gov/pubmed/36146589
http://dx.doi.org/10.3390/vaccines10091511
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