Cargando…

Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors

Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahgolzari, Mehdi, Dianat-Moghadam, Hassan, Yavari, Afagh, Fiering, Steven N., Hefferon, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502313/
https://www.ncbi.nlm.nih.gov/pubmed/36146510
http://dx.doi.org/10.3390/vaccines10091431
_version_ 1784795674296975360
author Shahgolzari, Mehdi
Dianat-Moghadam, Hassan
Yavari, Afagh
Fiering, Steven N.
Hefferon, Kathleen
author_facet Shahgolzari, Mehdi
Dianat-Moghadam, Hassan
Yavari, Afagh
Fiering, Steven N.
Hefferon, Kathleen
author_sort Shahgolzari, Mehdi
collection PubMed
description Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for activation of local and systemic antitumor immunity. Interestingly, PVNP platforms combined with other tumor immunotherapeutic options and other modalities of oncotherapy can improve tumor efficacy treatment. These applications can be achieved by encapsulation of a wide range of active ingredients and conjugating ligands for targeting immune and tumor cells. This review presents the current breast cancer treatments based on PVNP platforms.
format Online
Article
Text
id pubmed-9502313
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95023132022-09-24 Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors Shahgolzari, Mehdi Dianat-Moghadam, Hassan Yavari, Afagh Fiering, Steven N. Hefferon, Kathleen Vaccines (Basel) Review Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for activation of local and systemic antitumor immunity. Interestingly, PVNP platforms combined with other tumor immunotherapeutic options and other modalities of oncotherapy can improve tumor efficacy treatment. These applications can be achieved by encapsulation of a wide range of active ingredients and conjugating ligands for targeting immune and tumor cells. This review presents the current breast cancer treatments based on PVNP platforms. MDPI 2022-08-30 /pmc/articles/PMC9502313/ /pubmed/36146510 http://dx.doi.org/10.3390/vaccines10091431 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shahgolzari, Mehdi
Dianat-Moghadam, Hassan
Yavari, Afagh
Fiering, Steven N.
Hefferon, Kathleen
Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors
title Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors
title_full Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors
title_fullStr Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors
title_full_unstemmed Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors
title_short Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors
title_sort multifunctional plant virus nanoparticles for targeting breast cancer tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502313/
https://www.ncbi.nlm.nih.gov/pubmed/36146510
http://dx.doi.org/10.3390/vaccines10091431
work_keys_str_mv AT shahgolzarimehdi multifunctionalplantvirusnanoparticlesfortargetingbreastcancertumors
AT dianatmoghadamhassan multifunctionalplantvirusnanoparticlesfortargetingbreastcancertumors
AT yavariafagh multifunctionalplantvirusnanoparticlesfortargetingbreastcancertumors
AT fieringstevenn multifunctionalplantvirusnanoparticlesfortargetingbreastcancertumors
AT hefferonkathleen multifunctionalplantvirusnanoparticlesfortargetingbreastcancertumors