Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4A(Mus)

Previous investigations of the Leishmania infantum eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure of LieIF4A inhibitors on the RNA-dependent ATPase...

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Detalles Bibliográficos
Autores principales: Abdelkrim, Yosser Zina, Harigua-Souiai, Emna, Bassoumi-Jamoussi, Imen, Barhoumi, Mourad, Banroques, Josette, Essafi-Benkhadir, Khadija, Nilges, Michael, Blondel, Arnaud, Tanner, N. Kyle, Guizani, Ikram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502374/
https://www.ncbi.nlm.nih.gov/pubmed/36144626
http://dx.doi.org/10.3390/molecules27185890

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