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Potential Use of Propolis in Phytocosmetic as Phytotherapeutic Constituent

Phytocosmetic is an important aspect of traditional medicine in several cultures. Researchers are now focusing to find new and effective ingredients of natural origin. Propolis is a natural beehive product extensively used in traditional medicine. We aimed in the present study to investigate the pot...

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Autores principales: Segueni, Narimane, Akkal, Salah, Benlabed, Kadour, Nieto, Gema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502464/
https://www.ncbi.nlm.nih.gov/pubmed/36144568
http://dx.doi.org/10.3390/molecules27185833
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author Segueni, Narimane
Akkal, Salah
Benlabed, Kadour
Nieto, Gema
author_facet Segueni, Narimane
Akkal, Salah
Benlabed, Kadour
Nieto, Gema
author_sort Segueni, Narimane
collection PubMed
description Phytocosmetic is an important aspect of traditional medicine in several cultures. Researchers are now focusing to find new and effective ingredients of natural origin. Propolis is a natural beehive product extensively used in traditional medicine. We aimed in the present study to investigate the potential use of propolis as an aesthetic and phytotherapeutic constituent in phytocosmetics. Propolis was extracted using 80% ethanol. Total phenolic and flavonoid contents were determined calorimetrically. Free radical scavenging ability and reducing capacity were evaluated using four assays and expressed as IC(50) values. Antibacterial activity was evaluated by the determination of minimum inhibitory concentration (MIC) on 11 Gram-positive and Gram-negative bacteria. The wound healing activity of 30% ethanolic extract and propolis ointment was studied using excision wounds in the anterio-dorsal side of the rats. The phenolic acid composition of the tested propolis was investigated using UFLC/MS-MS analysis. The tested propolis was rich in phenolic and flavonoid content and demonstrated an interesting antibacterial and antioxidant activity. Wounds treated with propolis appear to display a lesser degree of inflammation. Chemical analysis led to the identification of 11 phenolics. Among them, five are considered as main compounds: Chlorogenic acid (48.79 ± 5.01 ng/mL), Gallic acid (44.25 ± 6.40 ng/mL), Rutin (21.12 ± 3.57 ng/mL), Caffeic acid (28.19 ± 4.95 ng/mL), and trans-cinnamic acid (20.10 ± 6.51 ng/mL). Our results indicated that propolis can not only be used as a cosmetic ingredient but also be used as a preventative and curative constituent, which might be used as a barrier when applied externally on infected and non-infected skin.
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spelling pubmed-95024642022-09-24 Potential Use of Propolis in Phytocosmetic as Phytotherapeutic Constituent Segueni, Narimane Akkal, Salah Benlabed, Kadour Nieto, Gema Molecules Article Phytocosmetic is an important aspect of traditional medicine in several cultures. Researchers are now focusing to find new and effective ingredients of natural origin. Propolis is a natural beehive product extensively used in traditional medicine. We aimed in the present study to investigate the potential use of propolis as an aesthetic and phytotherapeutic constituent in phytocosmetics. Propolis was extracted using 80% ethanol. Total phenolic and flavonoid contents were determined calorimetrically. Free radical scavenging ability and reducing capacity were evaluated using four assays and expressed as IC(50) values. Antibacterial activity was evaluated by the determination of minimum inhibitory concentration (MIC) on 11 Gram-positive and Gram-negative bacteria. The wound healing activity of 30% ethanolic extract and propolis ointment was studied using excision wounds in the anterio-dorsal side of the rats. The phenolic acid composition of the tested propolis was investigated using UFLC/MS-MS analysis. The tested propolis was rich in phenolic and flavonoid content and demonstrated an interesting antibacterial and antioxidant activity. Wounds treated with propolis appear to display a lesser degree of inflammation. Chemical analysis led to the identification of 11 phenolics. Among them, five are considered as main compounds: Chlorogenic acid (48.79 ± 5.01 ng/mL), Gallic acid (44.25 ± 6.40 ng/mL), Rutin (21.12 ± 3.57 ng/mL), Caffeic acid (28.19 ± 4.95 ng/mL), and trans-cinnamic acid (20.10 ± 6.51 ng/mL). Our results indicated that propolis can not only be used as a cosmetic ingredient but also be used as a preventative and curative constituent, which might be used as a barrier when applied externally on infected and non-infected skin. MDPI 2022-09-08 /pmc/articles/PMC9502464/ /pubmed/36144568 http://dx.doi.org/10.3390/molecules27185833 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Segueni, Narimane
Akkal, Salah
Benlabed, Kadour
Nieto, Gema
Potential Use of Propolis in Phytocosmetic as Phytotherapeutic Constituent
title Potential Use of Propolis in Phytocosmetic as Phytotherapeutic Constituent
title_full Potential Use of Propolis in Phytocosmetic as Phytotherapeutic Constituent
title_fullStr Potential Use of Propolis in Phytocosmetic as Phytotherapeutic Constituent
title_full_unstemmed Potential Use of Propolis in Phytocosmetic as Phytotherapeutic Constituent
title_short Potential Use of Propolis in Phytocosmetic as Phytotherapeutic Constituent
title_sort potential use of propolis in phytocosmetic as phytotherapeutic constituent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502464/
https://www.ncbi.nlm.nih.gov/pubmed/36144568
http://dx.doi.org/10.3390/molecules27185833
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