Cargando…

Identification of SARS-CoV-2 Main Protease Inhibitors from a Library of Minor Cannabinoids by Biochemical Inhibition Assay and Surface Plasmon Resonance Characterized Binding Affinity

The replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by its main protease (M(pro)), which is a plausible therapeutic target for coronavirus disease 2019 (COVID-19). Although numerous in silico studies reported the potential inhibitory effects of natural pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Chang, Puopolo, Tess, Li, Huifang, Cai, Ang, Seeram, Navindra P., Ma, Hang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502466/ https://www.ncbi.nlm.nih.gov/pubmed/36144858 http://dx.doi.org/10.3390/molecules27186127

Ejemplares similares

Investigating cannabinoids as P2X purinoreceptor 4 ligands by using surface plasmon resonance and computational docking
por: Puopolo, Tess, et al.
Publicado: (2023)

Establishment of Human PD-1/PD-L1 Blockade Assay Based on Surface Plasmon Resonance (SPR) Biosensor
por: Puopolo, Tess, et al.
Publicado: (2023)

Cannflavins A and B with Anti-Ferroptosis, Anti-Glycation, and Antioxidant Activities Protect Human Keratinocytes in a Cell Death Model with Erastin and Reactive Carbonyl Species
por: Li, Huifang, et al.
Publicado: (2023)

Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase
por: Puopolo, Tess, et al.
Publicado: (2022)

Further investigation of blockade effects and binding affinities of selected natural compounds to immune checkpoint PD-1/PD-L1
por: Li, Huifang, et al.
Publicado: (2022)

Affinity Assays for Cannabinoids Detection: Are They Amenable to On-Site Screening?
por: Puiu, Mihaela, et al.
Publicado: (2022)

Evaluations of Skin Permeability of Cannabidiol and Its Topical Formulations by Skin Membrane-Based Parallel Artificial Membrane Permeability Assay and Franz Cell Diffusion Assay
por: Kirk, Riley D., et al.
Publicado: (2022)

Evaluation of cannabidiol’s inhibitory effect on alpha-glucosidase and its stability in simulated gastric and intestinal fluids
por: Ma, Hang, et al.
Publicado: (2021)

Receptor Binding Affinities of Synthetic Cannabinoids Determined by Non-Isotopic Receptor Binding Assay
por: Cha, Hye Jin, et al.
Publicado: (2019)

Biochemical screening for SARS-CoV-2 main protease inhibitors
por: Coelho, Camila, et al.
Publicado: (2020)

Chemical constituents of industrial hemp roots and their anti-inflammatory activities
por: Huang, Shijie, et al.
Publicado: (2023)

Virtual screening of peptides with high affinity for SARS-CoV-2 main protease
por: Porto, William Farias
Publicado: (2021)

Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review
por: Liu, Chang, et al.
Publicado: (2021)

Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity
por: Windsor, Ian W., et al.
Publicado: (2015)

Interactions of Cannabinoids With Biochemical Substrates
por: Thomas, Brian F
Publicado: (2017)

Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs)
por: Jia, Yuqing, et al.
Publicado: (2019)

What Is Authentic Maple Water? A Twelve-Month Shelf-Life Study of the Chemical Composition of Maple Water and Its Biological Activities
por: Torrey, Kara J., et al.
Publicado: (2023)

QSAR Model for Predicting the Cannabinoid Receptor 1 Binding Affinity and Dependence Potential of Synthetic Cannabinoids
por: Lee, Wonyoung, et al.
Publicado: (2020)

Plasmonic Library Based on Substrate-Supported Gradiential Plasmonic Arrays
por: Müller, Mareen B., et al.
Publicado: (2014)

Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate()
por: Kuo, Chih-Jung, et al.
Publicado: (2004)

Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation
por: Guo, Sheng, et al.
Publicado: (2021)

Synthesis and biological evaluations of oleanolic acid indole derivatives as hyaluronidase inhibitors with enhanced skin permeability
por: He, Hao, et al.
Publicado: (2021)

Selecting Diversified Compounds to Build a Tangible Library for Biological and Biochemical Assays
por: Gu, Qiong, et al.
Publicado: (2010)

In silico targeting SARS-CoV-2 spike protein and main protease by biochemical compounds
por: Babaeekhou, Laleh, et al.
Publicado: (2021)

Probing cytoplasmic and nuclear microRNAs in single living cells via plasmonic affinity sandwich assay
por: Liu, Jia, et al.
Publicado: (2018)

Preparation of Group I Introns for Biochemical Studies and Crystallization Assays by Native Affinity Purification
por: Vicens, Quentin, et al.
Publicado: (2009)

In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library
por: Shahhamzehei, Nasim, et al.
Publicado: (2022)

A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry
por: Gabriel, Jürgen, et al.
Publicado: (2019)

Synthesis and Biological Evaluations of Betulinic Acid Derivatives With Inhibitory Activity on Hyaluronidase and Anti-Inflammatory Effects Against Hyaluronic Acid Fragment Induced Inflammation
por: Luo, Zhujun, et al.
Publicado: (2022)

Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays
por: Ma, Chunlong, et al.
Publicado: (2022)

Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2
por: Ferreira, Juliana C., et al.
Publicado: (2020)

Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses
por: Walsh, Kenneth B., et al.
Publicado: (2021)

Cannabinol: History, Syntheses, and Biological Profile of the Greatest “Minor” Cannabinoid
por: Maioli, Chiara, et al.
Publicado: (2022)

Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection
por: Ge, Rui, et al.
Publicado: (2022)

Identification of high-affinity inhibitors of SARS-CoV-2 main protease: Towards the development of effective COVID-19 therapy
por: Mohammad, Taj, et al.
Publicado: (2020)

Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy
por: Shamsi, Anas, et al.
Publicado: (2020)

DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors
por: Jimmidi, Ravikumar, et al.
Publicado: (2023)

Therapeutic Potential of Minor Cannabinoids in Dermatological Diseases—A Synthetic Review
por: Kwiecień, Emilia, et al.
Publicado: (2023)

Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays
por: Christopeit, Tony, et al.
Publicado: (2013)

Inhibitor potency and assay conditions: A case study on SARS-CoV-2 main protease
por: Behnam, Mira A. M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lrlphlqelhs6jamtccaq5c5kq3