Cargando…

Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis

Altered cerebral structure and function have been observed in young survivors of acute lymphoblastic leukemia (ALL). However, the topological organization of the morphological brain networks (MBNs) has not yet been investigated at the individual level. Twenty-three young survivors of ALL and twenty...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhuang, Ying, Qian, Long, Wu, Lin, Chen, Linglong, He, Fei, Zhang, Shouhua, Cheung, Gerald L., Zhou, Fuqing, Gong, Honghan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502489/
https://www.ncbi.nlm.nih.gov/pubmed/36143019
http://dx.doi.org/10.3390/jcm11185362
_version_ 1784795718430490624
author Zhuang, Ying
Qian, Long
Wu, Lin
Chen, Linglong
He, Fei
Zhang, Shouhua
Cheung, Gerald L.
Zhou, Fuqing
Gong, Honghan
author_facet Zhuang, Ying
Qian, Long
Wu, Lin
Chen, Linglong
He, Fei
Zhang, Shouhua
Cheung, Gerald L.
Zhou, Fuqing
Gong, Honghan
author_sort Zhuang, Ying
collection PubMed
description Altered cerebral structure and function have been observed in young survivors of acute lymphoblastic leukemia (ALL). However, the topological organization of the morphological brain networks (MBNs) has not yet been investigated at the individual level. Twenty-three young survivors of ALL and twenty healthy controls (HCs) were recruited and underwent T1-weighted magnetic resonance imaging (MRI) scanning. After preprocessing and segmentation, individual-based MBNs were constructed based on the morphological similarity of gray matter using the combined Euclidean distance. Young survivors showed a significantly lower global clustering coefficient (p = 0.008) and local efficiency (p = 0.035) compared with HCs. In addition, ALL survivors exhibited bidirectional alterations (decreases and increases) in nodal centrality and efficiency around the Rolandic operculum and posterior occipital lobe (p < 0.05, false discovery rate (FDR) corrected). Altered nodal topological efficiencies were associated with off-therapy duration and verbal memory capacity in the digit span test (p < 0.05, FDR corrected). Network-based statistical analysis revealed decreased morphological connections mainly in the pallidum subnetwork, which was negatively correlated with off-therapy durations (p < 0.05). Overall, the topological organization of the individual-based MBNs was disrupted in the young survivors of ALL, which may play a crucial role in executive efficiency deficits.
format Online
Article
Text
id pubmed-9502489
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95024892022-09-24 Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis Zhuang, Ying Qian, Long Wu, Lin Chen, Linglong He, Fei Zhang, Shouhua Cheung, Gerald L. Zhou, Fuqing Gong, Honghan J Clin Med Article Altered cerebral structure and function have been observed in young survivors of acute lymphoblastic leukemia (ALL). However, the topological organization of the morphological brain networks (MBNs) has not yet been investigated at the individual level. Twenty-three young survivors of ALL and twenty healthy controls (HCs) were recruited and underwent T1-weighted magnetic resonance imaging (MRI) scanning. After preprocessing and segmentation, individual-based MBNs were constructed based on the morphological similarity of gray matter using the combined Euclidean distance. Young survivors showed a significantly lower global clustering coefficient (p = 0.008) and local efficiency (p = 0.035) compared with HCs. In addition, ALL survivors exhibited bidirectional alterations (decreases and increases) in nodal centrality and efficiency around the Rolandic operculum and posterior occipital lobe (p < 0.05, false discovery rate (FDR) corrected). Altered nodal topological efficiencies were associated with off-therapy duration and verbal memory capacity in the digit span test (p < 0.05, FDR corrected). Network-based statistical analysis revealed decreased morphological connections mainly in the pallidum subnetwork, which was negatively correlated with off-therapy durations (p < 0.05). Overall, the topological organization of the individual-based MBNs was disrupted in the young survivors of ALL, which may play a crucial role in executive efficiency deficits. MDPI 2022-09-13 /pmc/articles/PMC9502489/ /pubmed/36143019 http://dx.doi.org/10.3390/jcm11185362 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhuang, Ying
Qian, Long
Wu, Lin
Chen, Linglong
He, Fei
Zhang, Shouhua
Cheung, Gerald L.
Zhou, Fuqing
Gong, Honghan
Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis
title Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis
title_full Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis
title_fullStr Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis
title_full_unstemmed Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis
title_short Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis
title_sort is brain network efficiency reduced in young survivors of acute lymphoblastic leukemia?—evidence from individual-based morphological brain network analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502489/
https://www.ncbi.nlm.nih.gov/pubmed/36143019
http://dx.doi.org/10.3390/jcm11185362
work_keys_str_mv AT zhuangying isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis
AT qianlong isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis
AT wulin isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis
AT chenlinglong isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis
AT hefei isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis
AT zhangshouhua isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis
AT cheunggeraldl isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis
AT zhoufuqing isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis
AT gonghonghan isbrainnetworkefficiencyreducedinyoungsurvivorsofacutelymphoblasticleukemiaevidencefromindividualbasedmorphologicalbrainnetworkanalysis