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Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis
Altered cerebral structure and function have been observed in young survivors of acute lymphoblastic leukemia (ALL). However, the topological organization of the morphological brain networks (MBNs) has not yet been investigated at the individual level. Twenty-three young survivors of ALL and twenty...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502489/ https://www.ncbi.nlm.nih.gov/pubmed/36143019 http://dx.doi.org/10.3390/jcm11185362 |
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author | Zhuang, Ying Qian, Long Wu, Lin Chen, Linglong He, Fei Zhang, Shouhua Cheung, Gerald L. Zhou, Fuqing Gong, Honghan |
author_facet | Zhuang, Ying Qian, Long Wu, Lin Chen, Linglong He, Fei Zhang, Shouhua Cheung, Gerald L. Zhou, Fuqing Gong, Honghan |
author_sort | Zhuang, Ying |
collection | PubMed |
description | Altered cerebral structure and function have been observed in young survivors of acute lymphoblastic leukemia (ALL). However, the topological organization of the morphological brain networks (MBNs) has not yet been investigated at the individual level. Twenty-three young survivors of ALL and twenty healthy controls (HCs) were recruited and underwent T1-weighted magnetic resonance imaging (MRI) scanning. After preprocessing and segmentation, individual-based MBNs were constructed based on the morphological similarity of gray matter using the combined Euclidean distance. Young survivors showed a significantly lower global clustering coefficient (p = 0.008) and local efficiency (p = 0.035) compared with HCs. In addition, ALL survivors exhibited bidirectional alterations (decreases and increases) in nodal centrality and efficiency around the Rolandic operculum and posterior occipital lobe (p < 0.05, false discovery rate (FDR) corrected). Altered nodal topological efficiencies were associated with off-therapy duration and verbal memory capacity in the digit span test (p < 0.05, FDR corrected). Network-based statistical analysis revealed decreased morphological connections mainly in the pallidum subnetwork, which was negatively correlated with off-therapy durations (p < 0.05). Overall, the topological organization of the individual-based MBNs was disrupted in the young survivors of ALL, which may play a crucial role in executive efficiency deficits. |
format | Online Article Text |
id | pubmed-9502489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95024892022-09-24 Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis Zhuang, Ying Qian, Long Wu, Lin Chen, Linglong He, Fei Zhang, Shouhua Cheung, Gerald L. Zhou, Fuqing Gong, Honghan J Clin Med Article Altered cerebral structure and function have been observed in young survivors of acute lymphoblastic leukemia (ALL). However, the topological organization of the morphological brain networks (MBNs) has not yet been investigated at the individual level. Twenty-three young survivors of ALL and twenty healthy controls (HCs) were recruited and underwent T1-weighted magnetic resonance imaging (MRI) scanning. After preprocessing and segmentation, individual-based MBNs were constructed based on the morphological similarity of gray matter using the combined Euclidean distance. Young survivors showed a significantly lower global clustering coefficient (p = 0.008) and local efficiency (p = 0.035) compared with HCs. In addition, ALL survivors exhibited bidirectional alterations (decreases and increases) in nodal centrality and efficiency around the Rolandic operculum and posterior occipital lobe (p < 0.05, false discovery rate (FDR) corrected). Altered nodal topological efficiencies were associated with off-therapy duration and verbal memory capacity in the digit span test (p < 0.05, FDR corrected). Network-based statistical analysis revealed decreased morphological connections mainly in the pallidum subnetwork, which was negatively correlated with off-therapy durations (p < 0.05). Overall, the topological organization of the individual-based MBNs was disrupted in the young survivors of ALL, which may play a crucial role in executive efficiency deficits. MDPI 2022-09-13 /pmc/articles/PMC9502489/ /pubmed/36143019 http://dx.doi.org/10.3390/jcm11185362 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhuang, Ying Qian, Long Wu, Lin Chen, Linglong He, Fei Zhang, Shouhua Cheung, Gerald L. Zhou, Fuqing Gong, Honghan Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis |
title | Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis |
title_full | Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis |
title_fullStr | Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis |
title_full_unstemmed | Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis |
title_short | Is Brain Network Efficiency Reduced in Young Survivors of Acute Lymphoblastic Leukemia?—Evidence from Individual-Based Morphological Brain Network Analysis |
title_sort | is brain network efficiency reduced in young survivors of acute lymphoblastic leukemia?—evidence from individual-based morphological brain network analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502489/ https://www.ncbi.nlm.nih.gov/pubmed/36143019 http://dx.doi.org/10.3390/jcm11185362 |
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