Cargando…

Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases

Liver disease has become a major global health and economic burden due to its broad spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to end-stage liver disease, which has a large amount of matrix deposition that makes it difficult for the liver and hepatocy...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Yi, Luo, Qiulin, Que, Hanyun, Wang, Nan, Gong, Puyang, Gu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502508/
https://www.ncbi.nlm.nih.gov/pubmed/36142881
http://dx.doi.org/10.3390/ijms231810972
_version_ 1784795723115528192
author Ding, Yi
Luo, Qiulin
Que, Hanyun
Wang, Nan
Gong, Puyang
Gu, Jian
author_facet Ding, Yi
Luo, Qiulin
Que, Hanyun
Wang, Nan
Gong, Puyang
Gu, Jian
author_sort Ding, Yi
collection PubMed
description Liver disease has become a major global health and economic burden due to its broad spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to end-stage liver disease, which has a large amount of matrix deposition that makes it difficult for the liver and hepatocytes to regenerate. Liver transplantation is the only treatment for end-stage liver disease, but the shortage of suitable organs, expensive treatment costs and surgical complications greatly reduce patient survival rates. Therefore, there is an urgent need for an effective treatment modality. Cell-free therapy has become a research hotspot in the field of regenerative medicine. Mesenchymal stem cell (MSC)-derived exosomes have regulatory properties and transport functional “cargo” through physiological barriers to target cells to exert communication and regulatory activities. These exosomes also have little tumorigenic risk. MSC-derived exosomes promote hepatocyte proliferation and repair damaged liver tissue by participating in intercellular communication and regulating signal transduction, which supports their promise as a new strategy for the treatment of liver diseases. This paper reviews the physiological functions of exosomes and highlights the physiological changes and alterations in signaling pathways related to MSC-derived exosomes for the treatment of liver diseases in some relevant clinical studies. We also summarize the advantages of exosomes as drug delivery vehicles and discuss the challenges of exosome treatment of liver diseases in the future.
format Online
Article
Text
id pubmed-9502508
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95025082022-09-24 Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases Ding, Yi Luo, Qiulin Que, Hanyun Wang, Nan Gong, Puyang Gu, Jian Int J Mol Sci Review Liver disease has become a major global health and economic burden due to its broad spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to end-stage liver disease, which has a large amount of matrix deposition that makes it difficult for the liver and hepatocytes to regenerate. Liver transplantation is the only treatment for end-stage liver disease, but the shortage of suitable organs, expensive treatment costs and surgical complications greatly reduce patient survival rates. Therefore, there is an urgent need for an effective treatment modality. Cell-free therapy has become a research hotspot in the field of regenerative medicine. Mesenchymal stem cell (MSC)-derived exosomes have regulatory properties and transport functional “cargo” through physiological barriers to target cells to exert communication and regulatory activities. These exosomes also have little tumorigenic risk. MSC-derived exosomes promote hepatocyte proliferation and repair damaged liver tissue by participating in intercellular communication and regulating signal transduction, which supports their promise as a new strategy for the treatment of liver diseases. This paper reviews the physiological functions of exosomes and highlights the physiological changes and alterations in signaling pathways related to MSC-derived exosomes for the treatment of liver diseases in some relevant clinical studies. We also summarize the advantages of exosomes as drug delivery vehicles and discuss the challenges of exosome treatment of liver diseases in the future. MDPI 2022-09-19 /pmc/articles/PMC9502508/ /pubmed/36142881 http://dx.doi.org/10.3390/ijms231810972 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ding, Yi
Luo, Qiulin
Que, Hanyun
Wang, Nan
Gong, Puyang
Gu, Jian
Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases
title Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases
title_full Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases
title_fullStr Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases
title_full_unstemmed Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases
title_short Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases
title_sort mesenchymal stem cell-derived exosomes: a promising therapeutic agent for the treatment of liver diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502508/
https://www.ncbi.nlm.nih.gov/pubmed/36142881
http://dx.doi.org/10.3390/ijms231810972
work_keys_str_mv AT dingyi mesenchymalstemcellderivedexosomesapromisingtherapeuticagentforthetreatmentofliverdiseases
AT luoqiulin mesenchymalstemcellderivedexosomesapromisingtherapeuticagentforthetreatmentofliverdiseases
AT quehanyun mesenchymalstemcellderivedexosomesapromisingtherapeuticagentforthetreatmentofliverdiseases
AT wangnan mesenchymalstemcellderivedexosomesapromisingtherapeuticagentforthetreatmentofliverdiseases
AT gongpuyang mesenchymalstemcellderivedexosomesapromisingtherapeuticagentforthetreatmentofliverdiseases
AT gujian mesenchymalstemcellderivedexosomesapromisingtherapeuticagentforthetreatmentofliverdiseases