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Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review

Photodynamic therapy is an unconventional yet increasingly common method of treating dermatological diseases and cancer that is implemented more often in adults than in children. Current clinical uses include treatment of actinic keratosis, superficial basal cell carcinomas, and acne. Despite its hi...

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Autores principales: Mazur, Anna, Koziorowska, Katarzyna, Dynarowicz, Klaudia, Aebisher, David, Bartusik-Aebisher, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502525/
https://www.ncbi.nlm.nih.gov/pubmed/36145180
http://dx.doi.org/10.3390/nu14183805
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author Mazur, Anna
Koziorowska, Katarzyna
Dynarowicz, Klaudia
Aebisher, David
Bartusik-Aebisher, Dorota
author_facet Mazur, Anna
Koziorowska, Katarzyna
Dynarowicz, Klaudia
Aebisher, David
Bartusik-Aebisher, Dorota
author_sort Mazur, Anna
collection PubMed
description Photodynamic therapy is an unconventional yet increasingly common method of treating dermatological diseases and cancer that is implemented more often in adults than in children. Current clinical uses include treatment of actinic keratosis, superficial basal cell carcinomas, and acne. Despite its high efficiency, photodynamic therapy support supplements have recently been reported in the literature, including calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D, and vitamin D3 cholecalciferol. In clinical trials, photodynamic therapy enhanced with vitamin D or D3 supplementation has been reported for treatment of squamous cell skin cancers, actinic keratosis, and psoriasis. Experimental research on the effect of photodynamic therapy with vitamin D or D3 has also been carried out in breast cancer cell lines and in animal models. The aim of this review is to evaluate the usefulness and effectiveness of vitamin D and D3 as supports for photodynamic therapy. For this purpose, the Pubmed and Scopus literature databases were searched. The search keyword was: “vitamin D in photodynamic therapy”. In the analyzed articles (1979–2022), the authors found experimental evidence of a positive effect of vitamin D and D3 when used in conjunction with photodynamic therapy. An average of 6–30% (in one case, up to 10 times) increased response to photodynamic therapy was reported in combination with vitamin D and D3 as compared to photodynamic therapy alone. Implementing vitamin D and D3 as a supplement to photodynamic therapy is promising and may lead to further clinical trials and new clinical methodologies.
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spelling pubmed-95025252022-09-24 Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review Mazur, Anna Koziorowska, Katarzyna Dynarowicz, Klaudia Aebisher, David Bartusik-Aebisher, Dorota Nutrients Review Photodynamic therapy is an unconventional yet increasingly common method of treating dermatological diseases and cancer that is implemented more often in adults than in children. Current clinical uses include treatment of actinic keratosis, superficial basal cell carcinomas, and acne. Despite its high efficiency, photodynamic therapy support supplements have recently been reported in the literature, including calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D, and vitamin D3 cholecalciferol. In clinical trials, photodynamic therapy enhanced with vitamin D or D3 supplementation has been reported for treatment of squamous cell skin cancers, actinic keratosis, and psoriasis. Experimental research on the effect of photodynamic therapy with vitamin D or D3 has also been carried out in breast cancer cell lines and in animal models. The aim of this review is to evaluate the usefulness and effectiveness of vitamin D and D3 as supports for photodynamic therapy. For this purpose, the Pubmed and Scopus literature databases were searched. The search keyword was: “vitamin D in photodynamic therapy”. In the analyzed articles (1979–2022), the authors found experimental evidence of a positive effect of vitamin D and D3 when used in conjunction with photodynamic therapy. An average of 6–30% (in one case, up to 10 times) increased response to photodynamic therapy was reported in combination with vitamin D and D3 as compared to photodynamic therapy alone. Implementing vitamin D and D3 as a supplement to photodynamic therapy is promising and may lead to further clinical trials and new clinical methodologies. MDPI 2022-09-15 /pmc/articles/PMC9502525/ /pubmed/36145180 http://dx.doi.org/10.3390/nu14183805 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mazur, Anna
Koziorowska, Katarzyna
Dynarowicz, Klaudia
Aebisher, David
Bartusik-Aebisher, Dorota
Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review
title Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review
title_full Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review
title_fullStr Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review
title_full_unstemmed Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review
title_short Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review
title_sort vitamin d and vitamin d3 supplementation during photodynamic therapy: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502525/
https://www.ncbi.nlm.nih.gov/pubmed/36145180
http://dx.doi.org/10.3390/nu14183805
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