Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. T...

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Autores principales: Siopi, Maria, Papadopoulos, Antonios, Spiliopoulou, Anastasia, Paliogianni, Fotini, Abou-Chakra, Nissrine, Arendrup, Maiken Cavling, Damoulari, Christina, Tsioulos, Georgios, Giannitsioti, Efthymia, Frantzeskaki, Frantzeska, Tsangaris, Iraklis, Pournaras, Spyros, Meletiadis, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502558/
https://www.ncbi.nlm.nih.gov/pubmed/36135656
http://dx.doi.org/10.3390/jof8090931
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author Siopi, Maria
Papadopoulos, Antonios
Spiliopoulou, Anastasia
Paliogianni, Fotini
Abou-Chakra, Nissrine
Arendrup, Maiken Cavling
Damoulari, Christina
Tsioulos, Georgios
Giannitsioti, Efthymia
Frantzeskaki, Frantzeska
Tsangaris, Iraklis
Pournaras, Spyros
Meletiadis, Joseph
author_facet Siopi, Maria
Papadopoulos, Antonios
Spiliopoulou, Anastasia
Paliogianni, Fotini
Abou-Chakra, Nissrine
Arendrup, Maiken Cavling
Damoulari, Christina
Tsioulos, Georgios
Giannitsioti, Efthymia
Frantzeskaki, Frantzeska
Tsangaris, Iraklis
Pournaras, Spyros
Meletiadis, Joseph
author_sort Siopi, Maria
collection PubMed
description The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.
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spelling pubmed-95025582022-09-24 Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy Siopi, Maria Papadopoulos, Antonios Spiliopoulou, Anastasia Paliogianni, Fotini Abou-Chakra, Nissrine Arendrup, Maiken Cavling Damoulari, Christina Tsioulos, Georgios Giannitsioti, Efthymia Frantzeskaki, Frantzeska Tsangaris, Iraklis Pournaras, Spyros Meletiadis, Joseph J Fungi (Basel) Case Report The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1. MDPI 2022-09-01 /pmc/articles/PMC9502558/ /pubmed/36135656 http://dx.doi.org/10.3390/jof8090931 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Siopi, Maria
Papadopoulos, Antonios
Spiliopoulou, Anastasia
Paliogianni, Fotini
Abou-Chakra, Nissrine
Arendrup, Maiken Cavling
Damoulari, Christina
Tsioulos, Georgios
Giannitsioti, Efthymia
Frantzeskaki, Frantzeska
Tsangaris, Iraklis
Pournaras, Spyros
Meletiadis, Joseph
Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy
title Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy
title_full Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy
title_fullStr Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy
title_full_unstemmed Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy
title_short Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy
title_sort pan-echinocandin resistant c. parapsilosis harboring an f652s fks1 alteration in a patient with prolonged echinocandin therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502558/
https://www.ncbi.nlm.nih.gov/pubmed/36135656
http://dx.doi.org/10.3390/jof8090931
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