Cargando…

Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy

The decline in cardiac contractility due to damage or loss of cardiomyocytes is intensified by changes in the extracellular matrix leading to heart remodeling. An excessive matrix response in the ischemic cardiomyopathy may contribute to the elevated fibrotic compartment and diastolic dysfunction. F...

Descripción completa

Detalles Bibliográficos
Autores principales: Piątek-Matuszak, Patrycja, Pasławski, Robert, Pasławska, Urszula, Kiczak, Liliana, Płóciennik, Michał, Janiszewski, Adrian, Michałek, Marcin, Gwizdała, Adrian, Kaźmierczak, Jarosław, Gorący, Jarosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502668/
https://www.ncbi.nlm.nih.gov/pubmed/36143077
http://dx.doi.org/10.3390/jcm11185430
_version_ 1784795763363020800
author Piątek-Matuszak, Patrycja
Pasławski, Robert
Pasławska, Urszula
Kiczak, Liliana
Płóciennik, Michał
Janiszewski, Adrian
Michałek, Marcin
Gwizdała, Adrian
Kaźmierczak, Jarosław
Gorący, Jarosław
author_facet Piątek-Matuszak, Patrycja
Pasławski, Robert
Pasławska, Urszula
Kiczak, Liliana
Płóciennik, Michał
Janiszewski, Adrian
Michałek, Marcin
Gwizdała, Adrian
Kaźmierczak, Jarosław
Gorący, Jarosław
author_sort Piątek-Matuszak, Patrycja
collection PubMed
description The decline in cardiac contractility due to damage or loss of cardiomyocytes is intensified by changes in the extracellular matrix leading to heart remodeling. An excessive matrix response in the ischemic cardiomyopathy may contribute to the elevated fibrotic compartment and diastolic dysfunction. Fibroproliferation is a defense response aimed at quickly closing the damaged area and maintaining tissue integrity. Balance in this process is of paramount importance, as the reduced post-infarction response causes scar thinning and more pronounced left ventricular remodeling, while excessive fibrosis leads to impairment of heart function. Under normal conditions, migration of progenitor cells to the lesion site occurs. These cells have the potential to differentiate into myocytes in vitro, but the changed micro-environment in the heart after infarction does not allow such differentiation. Stem cell transplantation affects the extracellular matrix remodeling and thus may facilitate the improvement of left ventricular function. Studies show that mesenchymal stem cell therapy after infarct reduces fibrosis. However, the authors did not specify whether they meant the reduction of scarring as a result of regeneration or changes in the matrix. Research is also necessary to rule out long-term negative effects of post-acute infarct stem cell therapy.
format Online
Article
Text
id pubmed-9502668
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95026682022-09-24 Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy Piątek-Matuszak, Patrycja Pasławski, Robert Pasławska, Urszula Kiczak, Liliana Płóciennik, Michał Janiszewski, Adrian Michałek, Marcin Gwizdała, Adrian Kaźmierczak, Jarosław Gorący, Jarosław J Clin Med Review The decline in cardiac contractility due to damage or loss of cardiomyocytes is intensified by changes in the extracellular matrix leading to heart remodeling. An excessive matrix response in the ischemic cardiomyopathy may contribute to the elevated fibrotic compartment and diastolic dysfunction. Fibroproliferation is a defense response aimed at quickly closing the damaged area and maintaining tissue integrity. Balance in this process is of paramount importance, as the reduced post-infarction response causes scar thinning and more pronounced left ventricular remodeling, while excessive fibrosis leads to impairment of heart function. Under normal conditions, migration of progenitor cells to the lesion site occurs. These cells have the potential to differentiate into myocytes in vitro, but the changed micro-environment in the heart after infarction does not allow such differentiation. Stem cell transplantation affects the extracellular matrix remodeling and thus may facilitate the improvement of left ventricular function. Studies show that mesenchymal stem cell therapy after infarct reduces fibrosis. However, the authors did not specify whether they meant the reduction of scarring as a result of regeneration or changes in the matrix. Research is also necessary to rule out long-term negative effects of post-acute infarct stem cell therapy. MDPI 2022-09-15 /pmc/articles/PMC9502668/ /pubmed/36143077 http://dx.doi.org/10.3390/jcm11185430 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Piątek-Matuszak, Patrycja
Pasławski, Robert
Pasławska, Urszula
Kiczak, Liliana
Płóciennik, Michał
Janiszewski, Adrian
Michałek, Marcin
Gwizdała, Adrian
Kaźmierczak, Jarosław
Gorący, Jarosław
Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy
title Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy
title_full Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy
title_fullStr Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy
title_full_unstemmed Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy
title_short Assessment of Myocardial Diastolic Dysfunction as a Result of Myocardial Infarction and Extracellular Matrix Regulation Disorders in the Context of Mesenchymal Stem Cell Therapy
title_sort assessment of myocardial diastolic dysfunction as a result of myocardial infarction and extracellular matrix regulation disorders in the context of mesenchymal stem cell therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502668/
https://www.ncbi.nlm.nih.gov/pubmed/36143077
http://dx.doi.org/10.3390/jcm11185430
work_keys_str_mv AT piatekmatuszakpatrycja assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT pasławskirobert assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT pasławskaurszula assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT kiczakliliana assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT płociennikmichał assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT janiszewskiadrian assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT michałekmarcin assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT gwizdałaadrian assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT kazmierczakjarosław assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy
AT goracyjarosław assessmentofmyocardialdiastolicdysfunctionasaresultofmyocardialinfarctionandextracellularmatrixregulationdisordersinthecontextofmesenchymalstemcelltherapy