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The Different Clinical Courses of Legionnaires’ Disease in Newborns from the Same Maternity Hospital

In children, the incidence of Legionnaires’ disease (LD) is unknown, hospital-acquired LD is associated with clinical risk factors and environmental risk, and children with cell-mediated immune deficiency are at high risk of infection. Both newborns were born in the same delivery room; stayed in the...

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Autores principales: Kostic, Andrijana, Cukovic, Katarina, Stankovic, Lidija, Raskovic, Zorica, Nestorovic, Jelena, Savic, Dragana, Simovic, Aleksandra, Prodanovic, Tijana, Zivojinovic, Suzana, Andrejevic, Sladjana, Erovic, Ismihana, Djordjevic, Zorana, Rsovac, Snezana, Sazdanovic, Predrag, Stojkovic, Andjelka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502702/
https://www.ncbi.nlm.nih.gov/pubmed/36143827
http://dx.doi.org/10.3390/medicina58091150
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author Kostic, Andrijana
Cukovic, Katarina
Stankovic, Lidija
Raskovic, Zorica
Nestorovic, Jelena
Savic, Dragana
Simovic, Aleksandra
Prodanovic, Tijana
Zivojinovic, Suzana
Andrejevic, Sladjana
Erovic, Ismihana
Djordjevic, Zorana
Rsovac, Snezana
Sazdanovic, Predrag
Stojkovic, Andjelka
author_facet Kostic, Andrijana
Cukovic, Katarina
Stankovic, Lidija
Raskovic, Zorica
Nestorovic, Jelena
Savic, Dragana
Simovic, Aleksandra
Prodanovic, Tijana
Zivojinovic, Suzana
Andrejevic, Sladjana
Erovic, Ismihana
Djordjevic, Zorana
Rsovac, Snezana
Sazdanovic, Predrag
Stojkovic, Andjelka
author_sort Kostic, Andrijana
collection PubMed
description In children, the incidence of Legionnaires’ disease (LD) is unknown, hospital-acquired LD is associated with clinical risk factors and environmental risk, and children with cell-mediated immune deficiency are at high risk of infection. Both newborns were born in the same delivery room; stayed in the same hospital room where they were cared for, bathed, and breastfed; were male; were born on time, with normal birth weight, and with high Apgar score at birth; and survived this severe infection (L. pneumophila, serogroup 2-15) but with different clinical courses. In neonate 1, bleeding in the brain, thrombosis of deep pelvic veins, and necrosis of the lungs, which left behind cystic and cavernous changes in the lungs, were found, while neonate 2 suffered from pneumonia alone. The only difference in risk factors for LD between these two newborns is the number of days of illness until the start of azithromycin treatment (sixth versus the third day of illness). We suggest that a change in the guidelines for diagnosing and treating community-acquired pneumonia and hospital-acquired pneumonia in newborns is needed in terms of mandatory routine testing for Legionella pneumophila. Early initiation of macrolide therapy is crucial for the outcome of LD in the newborn.
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spelling pubmed-95027022022-09-24 The Different Clinical Courses of Legionnaires’ Disease in Newborns from the Same Maternity Hospital Kostic, Andrijana Cukovic, Katarina Stankovic, Lidija Raskovic, Zorica Nestorovic, Jelena Savic, Dragana Simovic, Aleksandra Prodanovic, Tijana Zivojinovic, Suzana Andrejevic, Sladjana Erovic, Ismihana Djordjevic, Zorana Rsovac, Snezana Sazdanovic, Predrag Stojkovic, Andjelka Medicina (Kaunas) Case Report In children, the incidence of Legionnaires’ disease (LD) is unknown, hospital-acquired LD is associated with clinical risk factors and environmental risk, and children with cell-mediated immune deficiency are at high risk of infection. Both newborns were born in the same delivery room; stayed in the same hospital room where they were cared for, bathed, and breastfed; were male; were born on time, with normal birth weight, and with high Apgar score at birth; and survived this severe infection (L. pneumophila, serogroup 2-15) but with different clinical courses. In neonate 1, bleeding in the brain, thrombosis of deep pelvic veins, and necrosis of the lungs, which left behind cystic and cavernous changes in the lungs, were found, while neonate 2 suffered from pneumonia alone. The only difference in risk factors for LD between these two newborns is the number of days of illness until the start of azithromycin treatment (sixth versus the third day of illness). We suggest that a change in the guidelines for diagnosing and treating community-acquired pneumonia and hospital-acquired pneumonia in newborns is needed in terms of mandatory routine testing for Legionella pneumophila. Early initiation of macrolide therapy is crucial for the outcome of LD in the newborn. MDPI 2022-08-24 /pmc/articles/PMC9502702/ /pubmed/36143827 http://dx.doi.org/10.3390/medicina58091150 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kostic, Andrijana
Cukovic, Katarina
Stankovic, Lidija
Raskovic, Zorica
Nestorovic, Jelena
Savic, Dragana
Simovic, Aleksandra
Prodanovic, Tijana
Zivojinovic, Suzana
Andrejevic, Sladjana
Erovic, Ismihana
Djordjevic, Zorana
Rsovac, Snezana
Sazdanovic, Predrag
Stojkovic, Andjelka
The Different Clinical Courses of Legionnaires’ Disease in Newborns from the Same Maternity Hospital
title The Different Clinical Courses of Legionnaires’ Disease in Newborns from the Same Maternity Hospital
title_full The Different Clinical Courses of Legionnaires’ Disease in Newborns from the Same Maternity Hospital
title_fullStr The Different Clinical Courses of Legionnaires’ Disease in Newborns from the Same Maternity Hospital
title_full_unstemmed The Different Clinical Courses of Legionnaires’ Disease in Newborns from the Same Maternity Hospital
title_short The Different Clinical Courses of Legionnaires’ Disease in Newborns from the Same Maternity Hospital
title_sort different clinical courses of legionnaires’ disease in newborns from the same maternity hospital
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502702/
https://www.ncbi.nlm.nih.gov/pubmed/36143827
http://dx.doi.org/10.3390/medicina58091150
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