Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model

Staphylococcus aureus induces the expression of VCAM-1, P- and E-selectins on the endothelial cells of the EA.hy926 cell line but, at the same time, causes the significant suppression of the force and work of adhesion between these receptors of endotheliocytes and the receptors of neutrophils in an...

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Autores principales: Pleskova, Svetlana N., Bobyk, Sergey Z., Kriukov, Ruslan N., Gorshkova, Ekaterina N., Bezrukov, Nikolay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502802/
https://www.ncbi.nlm.nih.gov/pubmed/36144298
http://dx.doi.org/10.3390/microorganisms10091696
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author Pleskova, Svetlana N.
Bobyk, Sergey Z.
Kriukov, Ruslan N.
Gorshkova, Ekaterina N.
Bezrukov, Nikolay A.
author_facet Pleskova, Svetlana N.
Bobyk, Sergey Z.
Kriukov, Ruslan N.
Gorshkova, Ekaterina N.
Bezrukov, Nikolay A.
author_sort Pleskova, Svetlana N.
collection PubMed
description Staphylococcus aureus induces the expression of VCAM-1, P- and E-selectins on the endothelial cells of the EA.hy926 cell line but, at the same time, causes the significant suppression of the force and work of adhesion between these receptors of endotheliocytes and the receptors of neutrophils in an experimental septicemia model. Adhesion contacts between the receptors of neutrophils and endotheliocytes are statistically significantly suppressed under non-opsonized and opsonized S. aureus treatment, which disrupts the initial stage of transendothelial migration of neutrophils—adhesion. Thus, S. aureus causes the arrest of neutrophils in the bloodstream in an experimental septicemia model.
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spelling pubmed-95028022022-09-24 Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model Pleskova, Svetlana N. Bobyk, Sergey Z. Kriukov, Ruslan N. Gorshkova, Ekaterina N. Bezrukov, Nikolay A. Microorganisms Article Staphylococcus aureus induces the expression of VCAM-1, P- and E-selectins on the endothelial cells of the EA.hy926 cell line but, at the same time, causes the significant suppression of the force and work of adhesion between these receptors of endotheliocytes and the receptors of neutrophils in an experimental septicemia model. Adhesion contacts between the receptors of neutrophils and endotheliocytes are statistically significantly suppressed under non-opsonized and opsonized S. aureus treatment, which disrupts the initial stage of transendothelial migration of neutrophils—adhesion. Thus, S. aureus causes the arrest of neutrophils in the bloodstream in an experimental septicemia model. MDPI 2022-08-24 /pmc/articles/PMC9502802/ /pubmed/36144298 http://dx.doi.org/10.3390/microorganisms10091696 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pleskova, Svetlana N.
Bobyk, Sergey Z.
Kriukov, Ruslan N.
Gorshkova, Ekaterina N.
Bezrukov, Nikolay A.
Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model
title Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model
title_full Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model
title_fullStr Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model
title_full_unstemmed Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model
title_short Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model
title_sort staphylococcus aureus causes the arrest of neutrophils in the bloodstream in a septicemia model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502802/
https://www.ncbi.nlm.nih.gov/pubmed/36144298
http://dx.doi.org/10.3390/microorganisms10091696
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