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Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model
Staphylococcus aureus induces the expression of VCAM-1, P- and E-selectins on the endothelial cells of the EA.hy926 cell line but, at the same time, causes the significant suppression of the force and work of adhesion between these receptors of endotheliocytes and the receptors of neutrophils in an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502802/ https://www.ncbi.nlm.nih.gov/pubmed/36144298 http://dx.doi.org/10.3390/microorganisms10091696 |
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author | Pleskova, Svetlana N. Bobyk, Sergey Z. Kriukov, Ruslan N. Gorshkova, Ekaterina N. Bezrukov, Nikolay A. |
author_facet | Pleskova, Svetlana N. Bobyk, Sergey Z. Kriukov, Ruslan N. Gorshkova, Ekaterina N. Bezrukov, Nikolay A. |
author_sort | Pleskova, Svetlana N. |
collection | PubMed |
description | Staphylococcus aureus induces the expression of VCAM-1, P- and E-selectins on the endothelial cells of the EA.hy926 cell line but, at the same time, causes the significant suppression of the force and work of adhesion between these receptors of endotheliocytes and the receptors of neutrophils in an experimental septicemia model. Adhesion contacts between the receptors of neutrophils and endotheliocytes are statistically significantly suppressed under non-opsonized and opsonized S. aureus treatment, which disrupts the initial stage of transendothelial migration of neutrophils—adhesion. Thus, S. aureus causes the arrest of neutrophils in the bloodstream in an experimental septicemia model. |
format | Online Article Text |
id | pubmed-9502802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95028022022-09-24 Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model Pleskova, Svetlana N. Bobyk, Sergey Z. Kriukov, Ruslan N. Gorshkova, Ekaterina N. Bezrukov, Nikolay A. Microorganisms Article Staphylococcus aureus induces the expression of VCAM-1, P- and E-selectins on the endothelial cells of the EA.hy926 cell line but, at the same time, causes the significant suppression of the force and work of adhesion between these receptors of endotheliocytes and the receptors of neutrophils in an experimental septicemia model. Adhesion contacts between the receptors of neutrophils and endotheliocytes are statistically significantly suppressed under non-opsonized and opsonized S. aureus treatment, which disrupts the initial stage of transendothelial migration of neutrophils—adhesion. Thus, S. aureus causes the arrest of neutrophils in the bloodstream in an experimental septicemia model. MDPI 2022-08-24 /pmc/articles/PMC9502802/ /pubmed/36144298 http://dx.doi.org/10.3390/microorganisms10091696 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pleskova, Svetlana N. Bobyk, Sergey Z. Kriukov, Ruslan N. Gorshkova, Ekaterina N. Bezrukov, Nikolay A. Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model |
title | Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model |
title_full | Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model |
title_fullStr | Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model |
title_full_unstemmed | Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model |
title_short | Staphylococcus aureus Causes the Arrest of Neutrophils in the Bloodstream in a Septicemia Model |
title_sort | staphylococcus aureus causes the arrest of neutrophils in the bloodstream in a septicemia model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502802/ https://www.ncbi.nlm.nih.gov/pubmed/36144298 http://dx.doi.org/10.3390/microorganisms10091696 |
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