Cargando…

Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease

Vinculin and talin-1, which are cytoskeletal proteins affecting focal adhesions, were reported to be down-expressed in atherosclerotic lesions. Recently, we reported high concentrations of plasma talin-1 in patients with coronary artery disease (CAD). However, blood vinculin concentrations in CAD pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Aoyama, Masayuki, Kishimoto, Yoshimi, Saita, Emi, Ohmori, Reiko, Tanimoto, Kojiro, Nakamura, Masato, Kondo, Kazuo, Momiyama, Yukihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502881/
https://www.ncbi.nlm.nih.gov/pubmed/36135831
http://dx.doi.org/10.3390/medsci10030046
_version_ 1784795814140313600
author Aoyama, Masayuki
Kishimoto, Yoshimi
Saita, Emi
Ohmori, Reiko
Tanimoto, Kojiro
Nakamura, Masato
Kondo, Kazuo
Momiyama, Yukihiko
author_facet Aoyama, Masayuki
Kishimoto, Yoshimi
Saita, Emi
Ohmori, Reiko
Tanimoto, Kojiro
Nakamura, Masato
Kondo, Kazuo
Momiyama, Yukihiko
author_sort Aoyama, Masayuki
collection PubMed
description Vinculin and talin-1, which are cytoskeletal proteins affecting focal adhesions, were reported to be down-expressed in atherosclerotic lesions. Recently, we reported high concentrations of plasma talin-1 in patients with coronary artery disease (CAD). However, blood vinculin concentrations in CAD patients have not been clarified. Plasma vinculin concentrations as well as talin-1 were studied in 327 patients in whom coronary angiography was performed. CAD was proven in 177 patients (1-vessel, n = 79; 2-vessel, n = 57; 3-vessel disease, n = 41). However, vinculin concentrations were not markedly different between the CAD(-) and CAD groups (median 122.5 vs. 119.6 pg/mL, p = 0.325) or among patients with CAD(-), 1-, 2-, and 3-vessel diseases (122.5, 112.8, 107.9, and 137.2 pg/mL, p = 0.202). In contrast, talin-1 concentrations were higher in CAD than the CAD(-) group (0.29 vs. 0.23 ng/mL, p = 0.006) and increased stepwise in the number of stenotic vessels: 0.23 in CAD(-), 0.28 in 1-vessel, 0.29 in 2-vessel, and 0.33 ng/mL in 3-vessel disease (p = 0.043). No correlation was observed between vinculin and talin-1 concentrations. In multivariate analysis, vinculin concentrations were not a factor for CAD. In conclusion, plasma vinculin concentrations in patients with CAD were not high and were not associated with the presence or severity of CAD.
format Online
Article
Text
id pubmed-9502881
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95028812022-09-24 Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease Aoyama, Masayuki Kishimoto, Yoshimi Saita, Emi Ohmori, Reiko Tanimoto, Kojiro Nakamura, Masato Kondo, Kazuo Momiyama, Yukihiko Med Sci (Basel) Article Vinculin and talin-1, which are cytoskeletal proteins affecting focal adhesions, were reported to be down-expressed in atherosclerotic lesions. Recently, we reported high concentrations of plasma talin-1 in patients with coronary artery disease (CAD). However, blood vinculin concentrations in CAD patients have not been clarified. Plasma vinculin concentrations as well as talin-1 were studied in 327 patients in whom coronary angiography was performed. CAD was proven in 177 patients (1-vessel, n = 79; 2-vessel, n = 57; 3-vessel disease, n = 41). However, vinculin concentrations were not markedly different between the CAD(-) and CAD groups (median 122.5 vs. 119.6 pg/mL, p = 0.325) or among patients with CAD(-), 1-, 2-, and 3-vessel diseases (122.5, 112.8, 107.9, and 137.2 pg/mL, p = 0.202). In contrast, talin-1 concentrations were higher in CAD than the CAD(-) group (0.29 vs. 0.23 ng/mL, p = 0.006) and increased stepwise in the number of stenotic vessels: 0.23 in CAD(-), 0.28 in 1-vessel, 0.29 in 2-vessel, and 0.33 ng/mL in 3-vessel disease (p = 0.043). No correlation was observed between vinculin and talin-1 concentrations. In multivariate analysis, vinculin concentrations were not a factor for CAD. In conclusion, plasma vinculin concentrations in patients with CAD were not high and were not associated with the presence or severity of CAD. MDPI 2022-08-26 /pmc/articles/PMC9502881/ /pubmed/36135831 http://dx.doi.org/10.3390/medsci10030046 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aoyama, Masayuki
Kishimoto, Yoshimi
Saita, Emi
Ohmori, Reiko
Tanimoto, Kojiro
Nakamura, Masato
Kondo, Kazuo
Momiyama, Yukihiko
Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease
title Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease
title_full Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease
title_fullStr Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease
title_full_unstemmed Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease
title_short Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease
title_sort plasma concentrations of vinculin versus talin-1 in coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502881/
https://www.ncbi.nlm.nih.gov/pubmed/36135831
http://dx.doi.org/10.3390/medsci10030046
work_keys_str_mv AT aoyamamasayuki plasmaconcentrationsofvinculinversustalin1incoronaryarterydisease
AT kishimotoyoshimi plasmaconcentrationsofvinculinversustalin1incoronaryarterydisease
AT saitaemi plasmaconcentrationsofvinculinversustalin1incoronaryarterydisease
AT ohmorireiko plasmaconcentrationsofvinculinversustalin1incoronaryarterydisease
AT tanimotokojiro plasmaconcentrationsofvinculinversustalin1incoronaryarterydisease
AT nakamuramasato plasmaconcentrationsofvinculinversustalin1incoronaryarterydisease
AT kondokazuo plasmaconcentrationsofvinculinversustalin1incoronaryarterydisease
AT momiyamayukihiko plasmaconcentrationsofvinculinversustalin1incoronaryarterydisease