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Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease
Vinculin and talin-1, which are cytoskeletal proteins affecting focal adhesions, were reported to be down-expressed in atherosclerotic lesions. Recently, we reported high concentrations of plasma talin-1 in patients with coronary artery disease (CAD). However, blood vinculin concentrations in CAD pa...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502881/ https://www.ncbi.nlm.nih.gov/pubmed/36135831 http://dx.doi.org/10.3390/medsci10030046 |
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author | Aoyama, Masayuki Kishimoto, Yoshimi Saita, Emi Ohmori, Reiko Tanimoto, Kojiro Nakamura, Masato Kondo, Kazuo Momiyama, Yukihiko |
author_facet | Aoyama, Masayuki Kishimoto, Yoshimi Saita, Emi Ohmori, Reiko Tanimoto, Kojiro Nakamura, Masato Kondo, Kazuo Momiyama, Yukihiko |
author_sort | Aoyama, Masayuki |
collection | PubMed |
description | Vinculin and talin-1, which are cytoskeletal proteins affecting focal adhesions, were reported to be down-expressed in atherosclerotic lesions. Recently, we reported high concentrations of plasma talin-1 in patients with coronary artery disease (CAD). However, blood vinculin concentrations in CAD patients have not been clarified. Plasma vinculin concentrations as well as talin-1 were studied in 327 patients in whom coronary angiography was performed. CAD was proven in 177 patients (1-vessel, n = 79; 2-vessel, n = 57; 3-vessel disease, n = 41). However, vinculin concentrations were not markedly different between the CAD(-) and CAD groups (median 122.5 vs. 119.6 pg/mL, p = 0.325) or among patients with CAD(-), 1-, 2-, and 3-vessel diseases (122.5, 112.8, 107.9, and 137.2 pg/mL, p = 0.202). In contrast, talin-1 concentrations were higher in CAD than the CAD(-) group (0.29 vs. 0.23 ng/mL, p = 0.006) and increased stepwise in the number of stenotic vessels: 0.23 in CAD(-), 0.28 in 1-vessel, 0.29 in 2-vessel, and 0.33 ng/mL in 3-vessel disease (p = 0.043). No correlation was observed between vinculin and talin-1 concentrations. In multivariate analysis, vinculin concentrations were not a factor for CAD. In conclusion, plasma vinculin concentrations in patients with CAD were not high and were not associated with the presence or severity of CAD. |
format | Online Article Text |
id | pubmed-9502881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95028812022-09-24 Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease Aoyama, Masayuki Kishimoto, Yoshimi Saita, Emi Ohmori, Reiko Tanimoto, Kojiro Nakamura, Masato Kondo, Kazuo Momiyama, Yukihiko Med Sci (Basel) Article Vinculin and talin-1, which are cytoskeletal proteins affecting focal adhesions, were reported to be down-expressed in atherosclerotic lesions. Recently, we reported high concentrations of plasma talin-1 in patients with coronary artery disease (CAD). However, blood vinculin concentrations in CAD patients have not been clarified. Plasma vinculin concentrations as well as talin-1 were studied in 327 patients in whom coronary angiography was performed. CAD was proven in 177 patients (1-vessel, n = 79; 2-vessel, n = 57; 3-vessel disease, n = 41). However, vinculin concentrations were not markedly different between the CAD(-) and CAD groups (median 122.5 vs. 119.6 pg/mL, p = 0.325) or among patients with CAD(-), 1-, 2-, and 3-vessel diseases (122.5, 112.8, 107.9, and 137.2 pg/mL, p = 0.202). In contrast, talin-1 concentrations were higher in CAD than the CAD(-) group (0.29 vs. 0.23 ng/mL, p = 0.006) and increased stepwise in the number of stenotic vessels: 0.23 in CAD(-), 0.28 in 1-vessel, 0.29 in 2-vessel, and 0.33 ng/mL in 3-vessel disease (p = 0.043). No correlation was observed between vinculin and talin-1 concentrations. In multivariate analysis, vinculin concentrations were not a factor for CAD. In conclusion, plasma vinculin concentrations in patients with CAD were not high and were not associated with the presence or severity of CAD. MDPI 2022-08-26 /pmc/articles/PMC9502881/ /pubmed/36135831 http://dx.doi.org/10.3390/medsci10030046 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aoyama, Masayuki Kishimoto, Yoshimi Saita, Emi Ohmori, Reiko Tanimoto, Kojiro Nakamura, Masato Kondo, Kazuo Momiyama, Yukihiko Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease |
title | Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease |
title_full | Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease |
title_fullStr | Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease |
title_full_unstemmed | Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease |
title_short | Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease |
title_sort | plasma concentrations of vinculin versus talin-1 in coronary artery disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502881/ https://www.ncbi.nlm.nih.gov/pubmed/36135831 http://dx.doi.org/10.3390/medsci10030046 |
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