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Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update
For many years, vitamin D (VD) has been known to be an essential micronutrient with important relevance not only for the skeletal system, but also for numerous other mammalian organ systems. Low levels of VD result in a VD deficiency, which is a global health problem. Moreover, VD deficiencies are l...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502977/ https://www.ncbi.nlm.nih.gov/pubmed/36145088 http://dx.doi.org/10.3390/nu14183712 |
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author | Grzeczka, Arkadiusz Graczyk, Szymon Skowronska, Agnieszka Skowronski, Mariusz T. Kordowitzki, Paweł |
author_facet | Grzeczka, Arkadiusz Graczyk, Szymon Skowronska, Agnieszka Skowronski, Mariusz T. Kordowitzki, Paweł |
author_sort | Grzeczka, Arkadiusz |
collection | PubMed |
description | For many years, vitamin D (VD) has been known to be an essential micronutrient with important relevance not only for the skeletal system, but also for numerous other mammalian organ systems. Low levels of VD result in a VD deficiency, which is a global health problem. Moreover, VD deficiencies are linked to several pathologies, for instance, diseases of the cardiovascular system, diabetes mellitus, or sub- and infertility. In the past two decades, an increasing body of evidence has shown that adequate physiological levels of VD are crucial for the female gamete and its microenvironment, and VD deficiency has been associated with decreased live birth rates among women undergoing in vitro fertilization (IVF). With regard to the female reproductive tract, VD receptors (VDRs) have been detected in the ovary, endometrium, and the placenta. Although it has been reported that VD seems to be relevant for both calcium-dependent and independent pathways, its relevance for the oocyte’s developmental competence and life span remains elusive. Therefore, herein, we aim to provide an update on the importance of VD and VD deficiency for the oocyte and the follicular microenvironment. |
format | Online Article Text |
id | pubmed-9502977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95029772022-09-24 Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update Grzeczka, Arkadiusz Graczyk, Szymon Skowronska, Agnieszka Skowronski, Mariusz T. Kordowitzki, Paweł Nutrients Commentary For many years, vitamin D (VD) has been known to be an essential micronutrient with important relevance not only for the skeletal system, but also for numerous other mammalian organ systems. Low levels of VD result in a VD deficiency, which is a global health problem. Moreover, VD deficiencies are linked to several pathologies, for instance, diseases of the cardiovascular system, diabetes mellitus, or sub- and infertility. In the past two decades, an increasing body of evidence has shown that adequate physiological levels of VD are crucial for the female gamete and its microenvironment, and VD deficiency has been associated with decreased live birth rates among women undergoing in vitro fertilization (IVF). With regard to the female reproductive tract, VD receptors (VDRs) have been detected in the ovary, endometrium, and the placenta. Although it has been reported that VD seems to be relevant for both calcium-dependent and independent pathways, its relevance for the oocyte’s developmental competence and life span remains elusive. Therefore, herein, we aim to provide an update on the importance of VD and VD deficiency for the oocyte and the follicular microenvironment. MDPI 2022-09-09 /pmc/articles/PMC9502977/ /pubmed/36145088 http://dx.doi.org/10.3390/nu14183712 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Grzeczka, Arkadiusz Graczyk, Szymon Skowronska, Agnieszka Skowronski, Mariusz T. Kordowitzki, Paweł Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update |
title | Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update |
title_full | Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update |
title_fullStr | Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update |
title_full_unstemmed | Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update |
title_short | Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update |
title_sort | relevance of vitamin d and its deficiency for the ovarian follicle and the oocyte: an update |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502977/ https://www.ncbi.nlm.nih.gov/pubmed/36145088 http://dx.doi.org/10.3390/nu14183712 |
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