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Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update

For many years, vitamin D (VD) has been known to be an essential micronutrient with important relevance not only for the skeletal system, but also for numerous other mammalian organ systems. Low levels of VD result in a VD deficiency, which is a global health problem. Moreover, VD deficiencies are l...

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Autores principales: Grzeczka, Arkadiusz, Graczyk, Szymon, Skowronska, Agnieszka, Skowronski, Mariusz T., Kordowitzki, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502977/
https://www.ncbi.nlm.nih.gov/pubmed/36145088
http://dx.doi.org/10.3390/nu14183712
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author Grzeczka, Arkadiusz
Graczyk, Szymon
Skowronska, Agnieszka
Skowronski, Mariusz T.
Kordowitzki, Paweł
author_facet Grzeczka, Arkadiusz
Graczyk, Szymon
Skowronska, Agnieszka
Skowronski, Mariusz T.
Kordowitzki, Paweł
author_sort Grzeczka, Arkadiusz
collection PubMed
description For many years, vitamin D (VD) has been known to be an essential micronutrient with important relevance not only for the skeletal system, but also for numerous other mammalian organ systems. Low levels of VD result in a VD deficiency, which is a global health problem. Moreover, VD deficiencies are linked to several pathologies, for instance, diseases of the cardiovascular system, diabetes mellitus, or sub- and infertility. In the past two decades, an increasing body of evidence has shown that adequate physiological levels of VD are crucial for the female gamete and its microenvironment, and VD deficiency has been associated with decreased live birth rates among women undergoing in vitro fertilization (IVF). With regard to the female reproductive tract, VD receptors (VDRs) have been detected in the ovary, endometrium, and the placenta. Although it has been reported that VD seems to be relevant for both calcium-dependent and independent pathways, its relevance for the oocyte’s developmental competence and life span remains elusive. Therefore, herein, we aim to provide an update on the importance of VD and VD deficiency for the oocyte and the follicular microenvironment.
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spelling pubmed-95029772022-09-24 Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update Grzeczka, Arkadiusz Graczyk, Szymon Skowronska, Agnieszka Skowronski, Mariusz T. Kordowitzki, Paweł Nutrients Commentary For many years, vitamin D (VD) has been known to be an essential micronutrient with important relevance not only for the skeletal system, but also for numerous other mammalian organ systems. Low levels of VD result in a VD deficiency, which is a global health problem. Moreover, VD deficiencies are linked to several pathologies, for instance, diseases of the cardiovascular system, diabetes mellitus, or sub- and infertility. In the past two decades, an increasing body of evidence has shown that adequate physiological levels of VD are crucial for the female gamete and its microenvironment, and VD deficiency has been associated with decreased live birth rates among women undergoing in vitro fertilization (IVF). With regard to the female reproductive tract, VD receptors (VDRs) have been detected in the ovary, endometrium, and the placenta. Although it has been reported that VD seems to be relevant for both calcium-dependent and independent pathways, its relevance for the oocyte’s developmental competence and life span remains elusive. Therefore, herein, we aim to provide an update on the importance of VD and VD deficiency for the oocyte and the follicular microenvironment. MDPI 2022-09-09 /pmc/articles/PMC9502977/ /pubmed/36145088 http://dx.doi.org/10.3390/nu14183712 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Grzeczka, Arkadiusz
Graczyk, Szymon
Skowronska, Agnieszka
Skowronski, Mariusz T.
Kordowitzki, Paweł
Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update
title Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update
title_full Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update
title_fullStr Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update
title_full_unstemmed Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update
title_short Relevance of Vitamin D and Its Deficiency for the Ovarian Follicle and the Oocyte: An Update
title_sort relevance of vitamin d and its deficiency for the ovarian follicle and the oocyte: an update
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9502977/
https://www.ncbi.nlm.nih.gov/pubmed/36145088
http://dx.doi.org/10.3390/nu14183712
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