Bone-Targeting Nanoparticles of a Dendritic (Aspartic acid)(3)-Functionalized PEG-PLGA Biopolymer Encapsulating Simvastatin for the Treatment of Osteoporosis in Rat Models

Simvastatin (SIM) is a lipid-lowering drug that also promotes bone formation, but its high liver specificity may cause muscle damage, and the low solubility of lipophilic drugs limits the systemic administration of SIM, especially in osteoporosis (OP) studies. In this study, we utilized the bone-tar...

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Detalles Bibliográficos
Autores principales: Lin, Che-Wei, Lee, Chih-Yun, Lin, Sung-Yen, Kang, Lin, Fu, Yin-Chih, Chen, Chung-Hwan, Wang, Chih-Kuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503052/
https://www.ncbi.nlm.nih.gov/pubmed/36142447
http://dx.doi.org/10.3390/ijms231810530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503052/
https://www.ncbi.nlm.nih.gov/pubmed/36142447
http://dx.doi.org/10.3390/ijms231810530

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