Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report

During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked...

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Autores principales: Iannuzzi, Arcangelo, Parrella, Antonio, De Ritis, Francesca, Cammarota, Anna, Berloco, Lucia, Paudice, Francesca, D’Angelo, Giovanni, Aliberti, Emilio, Iannuzzo, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503064/
https://www.ncbi.nlm.nih.gov/pubmed/36143962
http://dx.doi.org/10.3390/medicina58091282
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author Iannuzzi, Arcangelo
Parrella, Antonio
De Ritis, Francesca
Cammarota, Anna
Berloco, Lucia
Paudice, Francesca
D’Angelo, Giovanni
Aliberti, Emilio
Iannuzzo, Gabriella
author_facet Iannuzzi, Arcangelo
Parrella, Antonio
De Ritis, Francesca
Cammarota, Anna
Berloco, Lucia
Paudice, Francesca
D’Angelo, Giovanni
Aliberti, Emilio
Iannuzzo, Gabriella
author_sort Iannuzzi, Arcangelo
collection PubMed
description During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked during the acute COVID-19 infection, but we can also suspect a direct role of the virus in the pathogenesis of the disease, or we can hypothesize that COVID-19 infection changed the phosphatidylinositol glycan class A (PIGA) gene pathway.
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spelling pubmed-95030642022-09-24 Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report Iannuzzi, Arcangelo Parrella, Antonio De Ritis, Francesca Cammarota, Anna Berloco, Lucia Paudice, Francesca D’Angelo, Giovanni Aliberti, Emilio Iannuzzo, Gabriella Medicina (Kaunas) Case Report During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked during the acute COVID-19 infection, but we can also suspect a direct role of the virus in the pathogenesis of the disease, or we can hypothesize that COVID-19 infection changed the phosphatidylinositol glycan class A (PIGA) gene pathway. MDPI 2022-09-15 /pmc/articles/PMC9503064/ /pubmed/36143962 http://dx.doi.org/10.3390/medicina58091282 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Iannuzzi, Arcangelo
Parrella, Antonio
De Ritis, Francesca
Cammarota, Anna
Berloco, Lucia
Paudice, Francesca
D’Angelo, Giovanni
Aliberti, Emilio
Iannuzzo, Gabriella
Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report
title Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report
title_full Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report
title_fullStr Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report
title_full_unstemmed Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report
title_short Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report
title_sort pancytopenia in a case of aplastic anaemia/paroxysmal nocturnal haemoglobinuria unmasked by sars-cov-2 infection: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503064/
https://www.ncbi.nlm.nih.gov/pubmed/36143962
http://dx.doi.org/10.3390/medicina58091282
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