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Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population

Aim. To study the associations of risk factors for chronic non-communicable diseases (CNCDs) and osteoporotic fractures (OFs) in a population sampling over 50 years. Materials and Methods. The data of a cross-sectional population-based study obtained in the Russian part of the international project...

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Autores principales: Mazurenko, Elena, Rymar, Oksana, Rerikh, Victor, Khrapova, Yuliya, Direev, Artem, Shcherbakova, Liliya, Malyutina, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503074/
https://www.ncbi.nlm.nih.gov/pubmed/36143260
http://dx.doi.org/10.3390/jpm12091475
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author Mazurenko, Elena
Rymar, Oksana
Rerikh, Victor
Khrapova, Yuliya
Direev, Artem
Shcherbakova, Liliya
Malyutina, Sofia
author_facet Mazurenko, Elena
Rymar, Oksana
Rerikh, Victor
Khrapova, Yuliya
Direev, Artem
Shcherbakova, Liliya
Malyutina, Sofia
author_sort Mazurenko, Elena
collection PubMed
description Aim. To study the associations of risk factors for chronic non-communicable diseases (CNCDs) and osteoporotic fractures (OFs) in a population sampling over 50 years. Materials and Methods. The data of a cross-sectional population-based study obtained in the Russian part of the international project HAPIEE (Novosibirsk) are analyzed. The present analysis comprised 7363 men and women aged 50–69 years old. We have assessed the frequency of OFs for the last 12 months and risk factors of CNCDs. Cross-sectional associations between OF history and potential determinants were analyzed using multivariable-adjusted logistic regression. Results. The frequency of OFs in the last 12 months was 3.6% (3.2% in men and 4.0% in women, p = 0.074). In men, the probability of OFs increased with an elevation of blood pressure (BP), high-density lipoprotein cholesterol (HDL-C), ethanol consumption, and reduced with increased body mass index (BMI). In women, the probability of a fracture increased with current smoking and an increased duration of post-menopause and reduced with an increase in triglycerides (TG) levels, independently of other factors. Conclusions. A syndemia of risk factors, both generally recognized for OFs (BMI, tobacco smoking, alcohol consumption, postmenopausal duration) and new factors associated with CNCDs (BP, HDL, TG), have been defined.
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spelling pubmed-95030742022-09-24 Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population Mazurenko, Elena Rymar, Oksana Rerikh, Victor Khrapova, Yuliya Direev, Artem Shcherbakova, Liliya Malyutina, Sofia J Pers Med Article Aim. To study the associations of risk factors for chronic non-communicable diseases (CNCDs) and osteoporotic fractures (OFs) in a population sampling over 50 years. Materials and Methods. The data of a cross-sectional population-based study obtained in the Russian part of the international project HAPIEE (Novosibirsk) are analyzed. The present analysis comprised 7363 men and women aged 50–69 years old. We have assessed the frequency of OFs for the last 12 months and risk factors of CNCDs. Cross-sectional associations between OF history and potential determinants were analyzed using multivariable-adjusted logistic regression. Results. The frequency of OFs in the last 12 months was 3.6% (3.2% in men and 4.0% in women, p = 0.074). In men, the probability of OFs increased with an elevation of blood pressure (BP), high-density lipoprotein cholesterol (HDL-C), ethanol consumption, and reduced with increased body mass index (BMI). In women, the probability of a fracture increased with current smoking and an increased duration of post-menopause and reduced with an increase in triglycerides (TG) levels, independently of other factors. Conclusions. A syndemia of risk factors, both generally recognized for OFs (BMI, tobacco smoking, alcohol consumption, postmenopausal duration) and new factors associated with CNCDs (BP, HDL, TG), have been defined. MDPI 2022-09-09 /pmc/articles/PMC9503074/ /pubmed/36143260 http://dx.doi.org/10.3390/jpm12091475 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mazurenko, Elena
Rymar, Oksana
Rerikh, Victor
Khrapova, Yuliya
Direev, Artem
Shcherbakova, Liliya
Malyutina, Sofia
Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population
title Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population
title_full Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population
title_fullStr Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population
title_full_unstemmed Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population
title_short Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population
title_sort risk factors for chronic non-communicable diseases and osteoporotic fractures in a middle and elderly-aged population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503074/
https://www.ncbi.nlm.nih.gov/pubmed/36143260
http://dx.doi.org/10.3390/jpm12091475
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