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SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations

There is accumulating evidence on the perinatal aspects of COVID-19, but available data are still insufficient. The reports on perinatal aspects of COVID-19 have been published on a small group of patients. Vertical transmission has been noted. The SARS-CoV-2 genome can be detected in umbilical cord...

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Autores principales: Pomorski, Michał, Trzeszcz, Martyna, Matera-Witkiewicz, Agnieszka, Krupińska, Magdalena, Fuchs, Tomasz, Zimmer, Mariusz, Zimmer-Stelmach, Aleksandra, Rosner-Tenerowicz, Anna, Budny-Wińska, Joanna, Tarczyńska-Podraza, Anna, Radziejewska, Klaudia, Królak-Olejnik, Barbara, Szczygieł, Anna, Augustyniak-Bartosik, Hanna, Kuriata-Kordek, Magdalena, Skalec, Karolina, Smoła, Izabela, Morgiel, Ewa, Gawryś, Jakub, Doroszko, Adrian, Rola, Piotr, Trocha, Małgorzata, Kujawa, Krzysztof, Adamik, Barbara, Kaliszewski, Krzysztof, Kiliś-Pstrusińska, Katarzyna, Protasiewicz, Marcin, Sokołowski, Janusz, Jankowska, Ewa A., Madziarska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503119/
https://www.ncbi.nlm.nih.gov/pubmed/36146849
http://dx.doi.org/10.3390/v14092043
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author Pomorski, Michał
Trzeszcz, Martyna
Matera-Witkiewicz, Agnieszka
Krupińska, Magdalena
Fuchs, Tomasz
Zimmer, Mariusz
Zimmer-Stelmach, Aleksandra
Rosner-Tenerowicz, Anna
Budny-Wińska, Joanna
Tarczyńska-Podraza, Anna
Radziejewska, Klaudia
Królak-Olejnik, Barbara
Szczygieł, Anna
Augustyniak-Bartosik, Hanna
Kuriata-Kordek, Magdalena
Skalec, Karolina
Smoła, Izabela
Morgiel, Ewa
Gawryś, Jakub
Doroszko, Adrian
Rola, Piotr
Trocha, Małgorzata
Kujawa, Krzysztof
Adamik, Barbara
Kaliszewski, Krzysztof
Kiliś-Pstrusińska, Katarzyna
Protasiewicz, Marcin
Sokołowski, Janusz
Jankowska, Ewa A.
Madziarska, Katarzyna
author_facet Pomorski, Michał
Trzeszcz, Martyna
Matera-Witkiewicz, Agnieszka
Krupińska, Magdalena
Fuchs, Tomasz
Zimmer, Mariusz
Zimmer-Stelmach, Aleksandra
Rosner-Tenerowicz, Anna
Budny-Wińska, Joanna
Tarczyńska-Podraza, Anna
Radziejewska, Klaudia
Królak-Olejnik, Barbara
Szczygieł, Anna
Augustyniak-Bartosik, Hanna
Kuriata-Kordek, Magdalena
Skalec, Karolina
Smoła, Izabela
Morgiel, Ewa
Gawryś, Jakub
Doroszko, Adrian
Rola, Piotr
Trocha, Małgorzata
Kujawa, Krzysztof
Adamik, Barbara
Kaliszewski, Krzysztof
Kiliś-Pstrusińska, Katarzyna
Protasiewicz, Marcin
Sokołowski, Janusz
Jankowska, Ewa A.
Madziarska, Katarzyna
author_sort Pomorski, Michał
collection PubMed
description There is accumulating evidence on the perinatal aspects of COVID-19, but available data are still insufficient. The reports on perinatal aspects of COVID-19 have been published on a small group of patients. Vertical transmission has been noted. The SARS-CoV-2 genome can be detected in umbilical cord blood and at-term placenta, and the infants demonstrate elevated SARS-CoV-2-specific IgG and IgM antibody levels. In this work, the analysis of clinical characteristics of RT-PCR SARS-CoV-2-positive pregnant women and their infants, along with the placental pathology correlation results, including villous trophoblast immunoexpression status for SARS-CoV-2 antibody, is presented. RT-PCR SARS-CoV-2 amniotic fluid testing was performed. Neonatal surveillance of infection status comprised RT-PCR testing of a nasopharyngeal swab and the measuring of levels of anti-SARS-CoV-2 in blood serum. In the initial study group were 161 pregnant women with positive test results. From that group, women who delivered during the hospital stay were selected for further analysis. Clinical data, laboratory results, placental histomorphology results, and neonatal outcomes were compared in women with immunohistochemistry (IHC)-con SARS-CoV-2-positive and IHC SARS-CoV-2-negative placentas (26 cases). A positive placental immunoprofile was noted in 8% of cases (n = 2), whereas 92% of cases were negative (n = 24). Women with placental infection proven by IHC had significantly different pathological findings from those without. One infected neonate was noted (n = 1; 4%). Infection was confirmed in perinatal autopsy, as there was the intrauterine fetal demise. The potential course of the infection with the risk of vertical transmission and implications for fetal–neonatal condition is critical for proper clinical management, which will involve comprehensive, multidisciplinary perinatal care for SARS-CoV-2-positive patients.
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spelling pubmed-95031192022-09-24 SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations Pomorski, Michał Trzeszcz, Martyna Matera-Witkiewicz, Agnieszka Krupińska, Magdalena Fuchs, Tomasz Zimmer, Mariusz Zimmer-Stelmach, Aleksandra Rosner-Tenerowicz, Anna Budny-Wińska, Joanna Tarczyńska-Podraza, Anna Radziejewska, Klaudia Królak-Olejnik, Barbara Szczygieł, Anna Augustyniak-Bartosik, Hanna Kuriata-Kordek, Magdalena Skalec, Karolina Smoła, Izabela Morgiel, Ewa Gawryś, Jakub Doroszko, Adrian Rola, Piotr Trocha, Małgorzata Kujawa, Krzysztof Adamik, Barbara Kaliszewski, Krzysztof Kiliś-Pstrusińska, Katarzyna Protasiewicz, Marcin Sokołowski, Janusz Jankowska, Ewa A. Madziarska, Katarzyna Viruses Article There is accumulating evidence on the perinatal aspects of COVID-19, but available data are still insufficient. The reports on perinatal aspects of COVID-19 have been published on a small group of patients. Vertical transmission has been noted. The SARS-CoV-2 genome can be detected in umbilical cord blood and at-term placenta, and the infants demonstrate elevated SARS-CoV-2-specific IgG and IgM antibody levels. In this work, the analysis of clinical characteristics of RT-PCR SARS-CoV-2-positive pregnant women and their infants, along with the placental pathology correlation results, including villous trophoblast immunoexpression status for SARS-CoV-2 antibody, is presented. RT-PCR SARS-CoV-2 amniotic fluid testing was performed. Neonatal surveillance of infection status comprised RT-PCR testing of a nasopharyngeal swab and the measuring of levels of anti-SARS-CoV-2 in blood serum. In the initial study group were 161 pregnant women with positive test results. From that group, women who delivered during the hospital stay were selected for further analysis. Clinical data, laboratory results, placental histomorphology results, and neonatal outcomes were compared in women with immunohistochemistry (IHC)-con SARS-CoV-2-positive and IHC SARS-CoV-2-negative placentas (26 cases). A positive placental immunoprofile was noted in 8% of cases (n = 2), whereas 92% of cases were negative (n = 24). Women with placental infection proven by IHC had significantly different pathological findings from those without. One infected neonate was noted (n = 1; 4%). Infection was confirmed in perinatal autopsy, as there was the intrauterine fetal demise. The potential course of the infection with the risk of vertical transmission and implications for fetal–neonatal condition is critical for proper clinical management, which will involve comprehensive, multidisciplinary perinatal care for SARS-CoV-2-positive patients. MDPI 2022-09-14 /pmc/articles/PMC9503119/ /pubmed/36146849 http://dx.doi.org/10.3390/v14092043 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pomorski, Michał
Trzeszcz, Martyna
Matera-Witkiewicz, Agnieszka
Krupińska, Magdalena
Fuchs, Tomasz
Zimmer, Mariusz
Zimmer-Stelmach, Aleksandra
Rosner-Tenerowicz, Anna
Budny-Wińska, Joanna
Tarczyńska-Podraza, Anna
Radziejewska, Klaudia
Królak-Olejnik, Barbara
Szczygieł, Anna
Augustyniak-Bartosik, Hanna
Kuriata-Kordek, Magdalena
Skalec, Karolina
Smoła, Izabela
Morgiel, Ewa
Gawryś, Jakub
Doroszko, Adrian
Rola, Piotr
Trocha, Małgorzata
Kujawa, Krzysztof
Adamik, Barbara
Kaliszewski, Krzysztof
Kiliś-Pstrusińska, Katarzyna
Protasiewicz, Marcin
Sokołowski, Janusz
Jankowska, Ewa A.
Madziarska, Katarzyna
SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations
title SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations
title_full SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations
title_fullStr SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations
title_full_unstemmed SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations
title_short SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations
title_sort sars-cov-2 infection and pregnancy: maternal and neonatal outcomes and placental pathology correlations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503119/
https://www.ncbi.nlm.nih.gov/pubmed/36146849
http://dx.doi.org/10.3390/v14092043
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