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SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations
There is accumulating evidence on the perinatal aspects of COVID-19, but available data are still insufficient. The reports on perinatal aspects of COVID-19 have been published on a small group of patients. Vertical transmission has been noted. The SARS-CoV-2 genome can be detected in umbilical cord...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503119/ https://www.ncbi.nlm.nih.gov/pubmed/36146849 http://dx.doi.org/10.3390/v14092043 |
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author | Pomorski, Michał Trzeszcz, Martyna Matera-Witkiewicz, Agnieszka Krupińska, Magdalena Fuchs, Tomasz Zimmer, Mariusz Zimmer-Stelmach, Aleksandra Rosner-Tenerowicz, Anna Budny-Wińska, Joanna Tarczyńska-Podraza, Anna Radziejewska, Klaudia Królak-Olejnik, Barbara Szczygieł, Anna Augustyniak-Bartosik, Hanna Kuriata-Kordek, Magdalena Skalec, Karolina Smoła, Izabela Morgiel, Ewa Gawryś, Jakub Doroszko, Adrian Rola, Piotr Trocha, Małgorzata Kujawa, Krzysztof Adamik, Barbara Kaliszewski, Krzysztof Kiliś-Pstrusińska, Katarzyna Protasiewicz, Marcin Sokołowski, Janusz Jankowska, Ewa A. Madziarska, Katarzyna |
author_facet | Pomorski, Michał Trzeszcz, Martyna Matera-Witkiewicz, Agnieszka Krupińska, Magdalena Fuchs, Tomasz Zimmer, Mariusz Zimmer-Stelmach, Aleksandra Rosner-Tenerowicz, Anna Budny-Wińska, Joanna Tarczyńska-Podraza, Anna Radziejewska, Klaudia Królak-Olejnik, Barbara Szczygieł, Anna Augustyniak-Bartosik, Hanna Kuriata-Kordek, Magdalena Skalec, Karolina Smoła, Izabela Morgiel, Ewa Gawryś, Jakub Doroszko, Adrian Rola, Piotr Trocha, Małgorzata Kujawa, Krzysztof Adamik, Barbara Kaliszewski, Krzysztof Kiliś-Pstrusińska, Katarzyna Protasiewicz, Marcin Sokołowski, Janusz Jankowska, Ewa A. Madziarska, Katarzyna |
author_sort | Pomorski, Michał |
collection | PubMed |
description | There is accumulating evidence on the perinatal aspects of COVID-19, but available data are still insufficient. The reports on perinatal aspects of COVID-19 have been published on a small group of patients. Vertical transmission has been noted. The SARS-CoV-2 genome can be detected in umbilical cord blood and at-term placenta, and the infants demonstrate elevated SARS-CoV-2-specific IgG and IgM antibody levels. In this work, the analysis of clinical characteristics of RT-PCR SARS-CoV-2-positive pregnant women and their infants, along with the placental pathology correlation results, including villous trophoblast immunoexpression status for SARS-CoV-2 antibody, is presented. RT-PCR SARS-CoV-2 amniotic fluid testing was performed. Neonatal surveillance of infection status comprised RT-PCR testing of a nasopharyngeal swab and the measuring of levels of anti-SARS-CoV-2 in blood serum. In the initial study group were 161 pregnant women with positive test results. From that group, women who delivered during the hospital stay were selected for further analysis. Clinical data, laboratory results, placental histomorphology results, and neonatal outcomes were compared in women with immunohistochemistry (IHC)-con SARS-CoV-2-positive and IHC SARS-CoV-2-negative placentas (26 cases). A positive placental immunoprofile was noted in 8% of cases (n = 2), whereas 92% of cases were negative (n = 24). Women with placental infection proven by IHC had significantly different pathological findings from those without. One infected neonate was noted (n = 1; 4%). Infection was confirmed in perinatal autopsy, as there was the intrauterine fetal demise. The potential course of the infection with the risk of vertical transmission and implications for fetal–neonatal condition is critical for proper clinical management, which will involve comprehensive, multidisciplinary perinatal care for SARS-CoV-2-positive patients. |
format | Online Article Text |
id | pubmed-9503119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95031192022-09-24 SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations Pomorski, Michał Trzeszcz, Martyna Matera-Witkiewicz, Agnieszka Krupińska, Magdalena Fuchs, Tomasz Zimmer, Mariusz Zimmer-Stelmach, Aleksandra Rosner-Tenerowicz, Anna Budny-Wińska, Joanna Tarczyńska-Podraza, Anna Radziejewska, Klaudia Królak-Olejnik, Barbara Szczygieł, Anna Augustyniak-Bartosik, Hanna Kuriata-Kordek, Magdalena Skalec, Karolina Smoła, Izabela Morgiel, Ewa Gawryś, Jakub Doroszko, Adrian Rola, Piotr Trocha, Małgorzata Kujawa, Krzysztof Adamik, Barbara Kaliszewski, Krzysztof Kiliś-Pstrusińska, Katarzyna Protasiewicz, Marcin Sokołowski, Janusz Jankowska, Ewa A. Madziarska, Katarzyna Viruses Article There is accumulating evidence on the perinatal aspects of COVID-19, but available data are still insufficient. The reports on perinatal aspects of COVID-19 have been published on a small group of patients. Vertical transmission has been noted. The SARS-CoV-2 genome can be detected in umbilical cord blood and at-term placenta, and the infants demonstrate elevated SARS-CoV-2-specific IgG and IgM antibody levels. In this work, the analysis of clinical characteristics of RT-PCR SARS-CoV-2-positive pregnant women and their infants, along with the placental pathology correlation results, including villous trophoblast immunoexpression status for SARS-CoV-2 antibody, is presented. RT-PCR SARS-CoV-2 amniotic fluid testing was performed. Neonatal surveillance of infection status comprised RT-PCR testing of a nasopharyngeal swab and the measuring of levels of anti-SARS-CoV-2 in blood serum. In the initial study group were 161 pregnant women with positive test results. From that group, women who delivered during the hospital stay were selected for further analysis. Clinical data, laboratory results, placental histomorphology results, and neonatal outcomes were compared in women with immunohistochemistry (IHC)-con SARS-CoV-2-positive and IHC SARS-CoV-2-negative placentas (26 cases). A positive placental immunoprofile was noted in 8% of cases (n = 2), whereas 92% of cases were negative (n = 24). Women with placental infection proven by IHC had significantly different pathological findings from those without. One infected neonate was noted (n = 1; 4%). Infection was confirmed in perinatal autopsy, as there was the intrauterine fetal demise. The potential course of the infection with the risk of vertical transmission and implications for fetal–neonatal condition is critical for proper clinical management, which will involve comprehensive, multidisciplinary perinatal care for SARS-CoV-2-positive patients. MDPI 2022-09-14 /pmc/articles/PMC9503119/ /pubmed/36146849 http://dx.doi.org/10.3390/v14092043 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pomorski, Michał Trzeszcz, Martyna Matera-Witkiewicz, Agnieszka Krupińska, Magdalena Fuchs, Tomasz Zimmer, Mariusz Zimmer-Stelmach, Aleksandra Rosner-Tenerowicz, Anna Budny-Wińska, Joanna Tarczyńska-Podraza, Anna Radziejewska, Klaudia Królak-Olejnik, Barbara Szczygieł, Anna Augustyniak-Bartosik, Hanna Kuriata-Kordek, Magdalena Skalec, Karolina Smoła, Izabela Morgiel, Ewa Gawryś, Jakub Doroszko, Adrian Rola, Piotr Trocha, Małgorzata Kujawa, Krzysztof Adamik, Barbara Kaliszewski, Krzysztof Kiliś-Pstrusińska, Katarzyna Protasiewicz, Marcin Sokołowski, Janusz Jankowska, Ewa A. Madziarska, Katarzyna SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations |
title | SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations |
title_full | SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations |
title_fullStr | SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations |
title_full_unstemmed | SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations |
title_short | SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations |
title_sort | sars-cov-2 infection and pregnancy: maternal and neonatal outcomes and placental pathology correlations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503119/ https://www.ncbi.nlm.nih.gov/pubmed/36146849 http://dx.doi.org/10.3390/v14092043 |
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