Cargando…

Nano-Based Co-Delivery System for Treatment of Rheumatoid Arthritis

A systemic autoimmune condition known as rheumatoid arthritis (RA) has a significant impact on patients’ quality of life. Given the complexity of RA’s biology, no single treatment can totally block the disease’s progression. The combined use of co-delivery regimens integrating various diverse mechan...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Shixin, Zhang, Miaomiao, Li, Xiangyu, Li, Ge, Yang, Bo, Lu, Xinyue, Gao, Yang, Sun, Fengying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503141/
https://www.ncbi.nlm.nih.gov/pubmed/36144709
http://dx.doi.org/10.3390/molecules27185973
_version_ 1784795889180606464
author Zhang, Shixin
Zhang, Miaomiao
Li, Xiangyu
Li, Ge
Yang, Bo
Lu, Xinyue
Gao, Yang
Sun, Fengying
author_facet Zhang, Shixin
Zhang, Miaomiao
Li, Xiangyu
Li, Ge
Yang, Bo
Lu, Xinyue
Gao, Yang
Sun, Fengying
author_sort Zhang, Shixin
collection PubMed
description A systemic autoimmune condition known as rheumatoid arthritis (RA) has a significant impact on patients’ quality of life. Given the complexity of RA’s biology, no single treatment can totally block the disease’s progression. The combined use of co-delivery regimens integrating various diverse mechanisms has been widely acknowledged as a way to make up for the drawbacks of single therapy. These days, co-delivery systems have been frequently utilized for co-treatment, getting over drug limitations, imaging of inflammatory areas, and inducing reactions. Various small molecules, nucleic acid drugs, and enzyme-like agents intended for co-delivery are frequently capable of producing the ability to require positive outcomes. In addition, the excellent response effect of phototherapeutic agents has led to their frequent use for delivery together with chemotherapeutics. In this review, we discuss different types of nano-based co-delivery systems and their advantages, limitations, and future directions. In addition, we review the prospects and predicted challenges for the combining of phototherapeutic agents with conventional drugs, hoping to provide some theoretical support for future in-depth studies of nano-based co-delivery systems and phototherapeutic agents.
format Online
Article
Text
id pubmed-9503141
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95031412022-09-24 Nano-Based Co-Delivery System for Treatment of Rheumatoid Arthritis Zhang, Shixin Zhang, Miaomiao Li, Xiangyu Li, Ge Yang, Bo Lu, Xinyue Gao, Yang Sun, Fengying Molecules Review A systemic autoimmune condition known as rheumatoid arthritis (RA) has a significant impact on patients’ quality of life. Given the complexity of RA’s biology, no single treatment can totally block the disease’s progression. The combined use of co-delivery regimens integrating various diverse mechanisms has been widely acknowledged as a way to make up for the drawbacks of single therapy. These days, co-delivery systems have been frequently utilized for co-treatment, getting over drug limitations, imaging of inflammatory areas, and inducing reactions. Various small molecules, nucleic acid drugs, and enzyme-like agents intended for co-delivery are frequently capable of producing the ability to require positive outcomes. In addition, the excellent response effect of phototherapeutic agents has led to their frequent use for delivery together with chemotherapeutics. In this review, we discuss different types of nano-based co-delivery systems and their advantages, limitations, and future directions. In addition, we review the prospects and predicted challenges for the combining of phototherapeutic agents with conventional drugs, hoping to provide some theoretical support for future in-depth studies of nano-based co-delivery systems and phototherapeutic agents. MDPI 2022-09-14 /pmc/articles/PMC9503141/ /pubmed/36144709 http://dx.doi.org/10.3390/molecules27185973 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Shixin
Zhang, Miaomiao
Li, Xiangyu
Li, Ge
Yang, Bo
Lu, Xinyue
Gao, Yang
Sun, Fengying
Nano-Based Co-Delivery System for Treatment of Rheumatoid Arthritis
title Nano-Based Co-Delivery System for Treatment of Rheumatoid Arthritis
title_full Nano-Based Co-Delivery System for Treatment of Rheumatoid Arthritis
title_fullStr Nano-Based Co-Delivery System for Treatment of Rheumatoid Arthritis
title_full_unstemmed Nano-Based Co-Delivery System for Treatment of Rheumatoid Arthritis
title_short Nano-Based Co-Delivery System for Treatment of Rheumatoid Arthritis
title_sort nano-based co-delivery system for treatment of rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503141/
https://www.ncbi.nlm.nih.gov/pubmed/36144709
http://dx.doi.org/10.3390/molecules27185973
work_keys_str_mv AT zhangshixin nanobasedcodeliverysystemfortreatmentofrheumatoidarthritis
AT zhangmiaomiao nanobasedcodeliverysystemfortreatmentofrheumatoidarthritis
AT lixiangyu nanobasedcodeliverysystemfortreatmentofrheumatoidarthritis
AT lige nanobasedcodeliverysystemfortreatmentofrheumatoidarthritis
AT yangbo nanobasedcodeliverysystemfortreatmentofrheumatoidarthritis
AT luxinyue nanobasedcodeliverysystemfortreatmentofrheumatoidarthritis
AT gaoyang nanobasedcodeliverysystemfortreatmentofrheumatoidarthritis
AT sunfengying nanobasedcodeliverysystemfortreatmentofrheumatoidarthritis