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Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis

BACKGROUND: Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs that activate the glucose-sensing enzyme glucokinase (GK). Pending formal cardiovascular outcome trials, we applied two-sample Mendelian randomisation (MR) to investigate the impact of GK activation on risk of...

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Detalles Bibliográficos
Autores principales:	Wang, Ke, Shi, Mai, Huang, Chuiguo, Fan, Baoqi, Luk, Andrea O. Y., Kong, Alice P. S., Ma, Ronald C. W., Chan, Juliana C. N., Chow, Elaine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503210/ https://www.ncbi.nlm.nih.gov/pubmed/36151532 http://dx.doi.org/10.1186/s12933-022-01613-6

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