Cargando…

A High-Affinity (64)Cu-Labeled Ligand for PET Imaging of Hepsin: Design, Synthesis, and Characterization

Hepsin, a cell surface serine protease, is a potential biomarker for the detection of prostate cancer due to its high expression in prostate cancer but not in normal prostate. This study aimed to develop a radioligand for positron emission tomography (PET) imaging of hepsin. Six leucine–arginine (Le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Ji-Hun, Zhang, Xuran, Ha, Hyunsoo, Kim, Jung Young, Choi, Joon Young, Lee, Kyung-Han, Byun, Youngjoo, Choe, Yearn Seong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503212/ https://www.ncbi.nlm.nih.gov/pubmed/36145330 http://dx.doi.org/10.3390/ph15091109

Ejemplares similares

Hybrid PET/optical imaging of integrin α(V)β(3) receptor expression using a (64)Cu-labeled streptavidin/biotin-based dimeric RGD peptide
por: Kang, Choong Mo, et al.
Publicado: (2015)

Synthesis and Evaluation of a (18)F-Labeled Ligand for PET Imaging of Colony-Stimulating Factor 1 Receptor
por: Lee, Hyeokjin, et al.
Publicado: (2022)

PET Tracing of Biodistribution for Orally Administered (64)Cu-Labeled Polystyrene in Mice
por: Im, Changkeun, et al.
Publicado: (2022)

PET Imaging of VEGFR with a Novel (64)Cu-Labeled Peptide
por: Hu, Kuan, et al.
Publicado: (2020)

Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells
por: Rodenas, Maria Carmen, et al.
Publicado: (2023)

(64)Cu-Labeled Inhibitors of Prostate-Specific Membrane Antigen for PET Imaging of Prostate Cancer
por: Banerjee, Sangeeta Ray, et al.
Publicado: (2014)

PET/CT Based In Vivo Evaluation of (64)Cu Labelled Nanodiscs in Tumor Bearing Mice
por: Huda, Pie, et al.
Publicado: (2015)

(64)Cu-Labeled LyP-1-Dendrimer for PET-CT Imaging of Atherosclerotic Plaque
por: Seo, Jai Woong, et al.
Publicado: (2014)

(64)Cu-Labeled Ubiquitin for PET Imaging of CXCR4 Expression in Mouse Breast Tumor
por: Li, Huiqiang, et al.
Publicado: (2019)

HEV-ORF3 Encoding Phosphoprotein Interacts With Hepsin
por: Wang, Chunyan, et al.
Publicado: (2014)

Improved PET Imaging of uPAR Expression Using new (64)Cu-labeled Cross-Bridged Peptide Ligands: Comparative in vitro and in vivo Studies
por: Persson, Morten, et al.
Publicado: (2013)

Radioimmunoimaging of Liver Metastases with PET Using a (64)Cu-Labeled CEA Antibody in Transgenic Mice
por: Nittka, Stefanie, et al.
Publicado: (2014)

[(64)Cu]Cu-DOTATATE PET metrics in the investigation of atherosclerotic inflammation in humans
por: Jensen, Jacob K., et al.
Publicado: (2022)

Pilot Study of (64)Cu(I) for PET Imaging of Melanoma
por: Jiang, Lei, et al.
Publicado: (2017)

(64)Cu-DOTATOC PET-CT in Patients with Neuroendocrine Tumors
por: Mirzaei, Siroos, et al.
Publicado: (2019)

High Hepsin expression predicts poor prognosis in Gastric Cancer
por: Zhang, Mingming, et al.
Publicado: (2016)

Hepsin regulates TGFβ signaling via fibronectin proteolysis
por: Belitškin, Denis, et al.
Publicado: (2021)

Clinical Significance of Hepsin and Underlying Signaling Pathways in Prostate Cancer
por: Lu, Lucy, et al.
Publicado: (2022)

Synthesis and in vivo characterization of (18)F-labeled difluoroboron-curcumin derivative for β-amyloid plaque imaging
por: Kim, Hyunjung, et al.
Publicado: (2019)

Effect of intratumoral administration on biodistribution of (64)Cu-labeled nanoshells
por: Xie, Huan, et al.
Publicado: (2012)

Synthesis and evaluation of (64)Cu-radiolabeled NOTA-cetuximab ((64)Cu-NOTA-C225) for immuno-PET imaging of EGFR expression
por: Xu, Xiaoxia, et al.
Publicado: (2019)

(64)Cu Labeled Sarcophagine Exendin-4 for MicroPET Imaging of Glucagon like Peptide-1 Receptor Expression
por: Wu, Zhanhong, et al.
Publicado: (2014)

Pilot Study of (64)CuCl(2) for PET Imaging of Inflammation
por: Jiang, Lei, et al.
Publicado: (2018)

Implication of Hepsin from Primary Tumor in the Prognosis of Colorectal Cancer Patients
por: Zaragoza-Huesca, David, et al.
Publicado: (2022)

Value of C-11 methionine PET/CT in patients with intracranial germinoma
por: Park, Yong-Jin, et al.
Publicado: (2022)

(64)Cu-ATSM and (18)FDG PET uptake and (64)Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry
por: Hansen, Anders E, et al.
Publicado: (2012)

[(64)Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma
por: Minn, Il, et al.
Publicado: (2016)

Comparison of the Effects of DOTA and NOTA Chelators on (64)Cu-Cudotadipep and (64)Cu-Cunotadipep for Prostate Cancer
por: Lee, Inki, et al.
Publicado: (2023)

A Novel PET Imaging Using (64)Cu-Labeled Monoclonal Antibody against Mesothelin Commonly Expressed on Cancer Cells
por: Kobayashi, Kazuko, et al.
Publicado: (2015)

[(64)Cu]‐labelled trastuzumab: optimisation of labelling by DOTA and NODAGA conjugation and initial evaluation in mice
por: Schjoeth‐Eskesen, Christina, et al.
Publicado: (2015)

The pathophysiology of Wilson’s disease visualized: A human (64)Cu PET study
por: Sandahl, Thomas Damgaard, et al.
Publicado: (2022)

Expression levels and clinical significance of hepsin and HMGB1 proteins in cervical carcinoma
por: Cheng, Hui, et al.
Publicado: (2017)

Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
por: Blay, Vincent, et al.
Publicado: (2020)

Initial Experience with (64)Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET
por: Loft, Mathias, et al.
Publicado: (2021)

Imaging Neurotensin Receptor in Prostate Cancer With (64)Cu-Labeled Neurotensin Analogs
por: Deng, Huaifu, et al.
Publicado: (2017)

Versatile Bispidine‐Based Bifunctional Chelators for (64)Cu(II)‐Labelling of Biomolecules
por: Singh, Garima, et al.
Publicado: (2020)

Increasing Reaction Rates of Water-Soluble Porphyrins for (64)Cu Radiopharmaceutical Labeling
por: Pęgier, Mateusz, et al.
Publicado: (2023)

PET imaging of occult tumours by temporal integration of tumour-acidosis signals from pH-sensitive (64)Cu-labelled polymers
por: Huang, Gang, et al.
Publicado: (2019)

Intrathecal [(64)Cu]Cu-albumin PET reveals age-related decline of lymphatic drainage of cerebrospinal fluid
por: Sarker, Azmal, et al.
Publicado: (2023)

Theragnostic (64)Cu/(67)Cu Radioisotopes Production With RFT-30 Cyclotron
por: Lee, Jun Young, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1vftfniormakh5nlv0tfe1mvdf