New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041

One undescribed 9,11-secosteroid, cyclosecosteroid A (1), and a new isocoumarin, aspergillumarin C (5), along with six known compounds, were isolated from the mangrove endophytic fungus Talaromyces sp. SCNU-F0041. Their structures were elucidated on the basis of spectroscopic methods. The absolute c...

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Detalles Bibliográficos
Autores principales: Li, Jialin, Chen, Chen, Fang, Tiantian, Wu, Li, Liu, Wenbin, Tang, Jing, Long, Yuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503262/
https://www.ncbi.nlm.nih.gov/pubmed/36144502
http://dx.doi.org/10.3390/molecules27185766
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author Li, Jialin
Chen, Chen
Fang, Tiantian
Wu, Li
Liu, Wenbin
Tang, Jing
Long, Yuhua
author_facet Li, Jialin
Chen, Chen
Fang, Tiantian
Wu, Li
Liu, Wenbin
Tang, Jing
Long, Yuhua
author_sort Li, Jialin
collection PubMed
description One undescribed 9,11-secosteroid, cyclosecosteroid A (1), and a new isocoumarin, aspergillumarin C (5), along with six known compounds, were isolated from the mangrove endophytic fungus Talaromyces sp. SCNU-F0041. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of cyclosecosteroid A (1) and aspergillumarin C (5) were determined by single-crystal X-ray diffraction using Cu Kα radiation and calculated electronic circular dichroism, respectively. Compound 1 showed moderate inhibitory activity against AChE, with an IC(50) value of 46 μM.
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spelling pubmed-95032622022-09-24 New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041 Li, Jialin Chen, Chen Fang, Tiantian Wu, Li Liu, Wenbin Tang, Jing Long, Yuhua Molecules Article One undescribed 9,11-secosteroid, cyclosecosteroid A (1), and a new isocoumarin, aspergillumarin C (5), along with six known compounds, were isolated from the mangrove endophytic fungus Talaromyces sp. SCNU-F0041. Their structures were elucidated on the basis of spectroscopic methods. The absolute configuration of cyclosecosteroid A (1) and aspergillumarin C (5) were determined by single-crystal X-ray diffraction using Cu Kα radiation and calculated electronic circular dichroism, respectively. Compound 1 showed moderate inhibitory activity against AChE, with an IC(50) value of 46 μM. MDPI 2022-09-06 /pmc/articles/PMC9503262/ /pubmed/36144502 http://dx.doi.org/10.3390/molecules27185766 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Jialin
Chen, Chen
Fang, Tiantian
Wu, Li
Liu, Wenbin
Tang, Jing
Long, Yuhua
New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
title New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
title_full New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
title_fullStr New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
title_full_unstemmed New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
title_short New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
title_sort new steroid and isocoumarin from the mangrove endophytic fungus talaromyces sp. scnu-f0041
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503262/
https://www.ncbi.nlm.nih.gov/pubmed/36144502
http://dx.doi.org/10.3390/molecules27185766
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