Cargando…
In Silico Evaluation of Hexamethylene Amiloride Derivatives as Potential Luminal Inhibitors of SARS-CoV-2 E Protein
The coronavirus E proteins are small membrane proteins found in the virus envelope of alpha and beta coronaviruses that have a high degree of overlap in their biochemical and functional properties despite minor sequence variations. The SARS-CoV-2 E is a 75-amino acid transmembrane protein capable of...
Autores principales: | Jalily, Pouria H., Jalily Hasani, Horia, Fedida, David |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503309/ https://www.ncbi.nlm.nih.gov/pubmed/36142556 http://dx.doi.org/10.3390/ijms231810647 |
Ejemplares similares
-
Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs
por: Vu, Kiem, et al.
Publicado: (2023) -
Hexamethylene amiloride binds the SARS‐CoV‐2 envelope protein at the protein–lipid interface
por: Somberg, Noah H., et al.
Publicado: (2023) -
Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication
por: Wilson, Lauren, et al.
Publicado: (2006) -
Put a cork in it: Plugging the M2 viral ion channel to sink influenza
por: Jalily, Pouria H., et al.
Publicado: (2020) -
Modeling the human Na(v)1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade
por: Ahmed, Marawan, et al.
Publicado: (2017)