Cargando…

Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation

Argus II retinal prosthesis is the US Food and Drug Administration (FDA) approved medical device intended to restore sight to a patient’s blind secondary to retinal degeneration (i.e., retinitis pigmentosa). However, Argus II and most reported retinal prostheses require invasive surgery to implant e...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Chenlin, Lu, Gengxi, Kang, Haochen, Humayun, Mark S., Zhou, Qifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503310/
https://www.ncbi.nlm.nih.gov/pubmed/36144157
http://dx.doi.org/10.3390/mi13091536
_version_ 1784795931818852352
author Xu, Chenlin
Lu, Gengxi
Kang, Haochen
Humayun, Mark S.
Zhou, Qifa
author_facet Xu, Chenlin
Lu, Gengxi
Kang, Haochen
Humayun, Mark S.
Zhou, Qifa
author_sort Xu, Chenlin
collection PubMed
description Argus II retinal prosthesis is the US Food and Drug Administration (FDA) approved medical device intended to restore sight to a patient’s blind secondary to retinal degeneration (i.e., retinitis pigmentosa). However, Argus II and most reported retinal prostheses require invasive surgery to implant electrodes in the eye. Recent studies have shown that focused ultrasound can be developed into a non-invasive retinal prosthesis technology. Ultrasound energy focused on retinal neurons can trigger the activities of retinal neurons with high spatial-temporal resolution. This paper introduces a novel design and simulation of a ring array transducer that could be used as non-invasive ultrasonic retinal stimulation. The array transducer is designed in the shape of a racing ring with a hemisphere surface that mimics a contact lens to acoustically couple with the eye via the tear film and directs the ultrasound to avoid the high acoustic absorption from the crystalline lens. We will describe the design methods and simulation of the two-dimensional pattern stimulation. Finally, compared with other existing retinal prostheses, we show that the ultrasound ring array is practical and safe and could be potentially used as a non-invasive retinal prosthesis.
format Online
Article
Text
id pubmed-9503310
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95033102022-09-24 Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation Xu, Chenlin Lu, Gengxi Kang, Haochen Humayun, Mark S. Zhou, Qifa Micromachines (Basel) Article Argus II retinal prosthesis is the US Food and Drug Administration (FDA) approved medical device intended to restore sight to a patient’s blind secondary to retinal degeneration (i.e., retinitis pigmentosa). However, Argus II and most reported retinal prostheses require invasive surgery to implant electrodes in the eye. Recent studies have shown that focused ultrasound can be developed into a non-invasive retinal prosthesis technology. Ultrasound energy focused on retinal neurons can trigger the activities of retinal neurons with high spatial-temporal resolution. This paper introduces a novel design and simulation of a ring array transducer that could be used as non-invasive ultrasonic retinal stimulation. The array transducer is designed in the shape of a racing ring with a hemisphere surface that mimics a contact lens to acoustically couple with the eye via the tear film and directs the ultrasound to avoid the high acoustic absorption from the crystalline lens. We will describe the design methods and simulation of the two-dimensional pattern stimulation. Finally, compared with other existing retinal prostheses, we show that the ultrasound ring array is practical and safe and could be potentially used as a non-invasive retinal prosthesis. MDPI 2022-09-16 /pmc/articles/PMC9503310/ /pubmed/36144157 http://dx.doi.org/10.3390/mi13091536 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Chenlin
Lu, Gengxi
Kang, Haochen
Humayun, Mark S.
Zhou, Qifa
Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation
title Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation
title_full Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation
title_fullStr Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation
title_full_unstemmed Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation
title_short Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation
title_sort design and simulation of a ring transducer array for ultrasound retinal stimulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503310/
https://www.ncbi.nlm.nih.gov/pubmed/36144157
http://dx.doi.org/10.3390/mi13091536
work_keys_str_mv AT xuchenlin designandsimulationofaringtransducerarrayforultrasoundretinalstimulation
AT lugengxi designandsimulationofaringtransducerarrayforultrasoundretinalstimulation
AT kanghaochen designandsimulationofaringtransducerarrayforultrasoundretinalstimulation
AT humayunmarks designandsimulationofaringtransducerarrayforultrasoundretinalstimulation
AT zhouqifa designandsimulationofaringtransducerarrayforultrasoundretinalstimulation