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Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation
Argus II retinal prosthesis is the US Food and Drug Administration (FDA) approved medical device intended to restore sight to a patient’s blind secondary to retinal degeneration (i.e., retinitis pigmentosa). However, Argus II and most reported retinal prostheses require invasive surgery to implant e...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503310/ https://www.ncbi.nlm.nih.gov/pubmed/36144157 http://dx.doi.org/10.3390/mi13091536 |
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author | Xu, Chenlin Lu, Gengxi Kang, Haochen Humayun, Mark S. Zhou, Qifa |
author_facet | Xu, Chenlin Lu, Gengxi Kang, Haochen Humayun, Mark S. Zhou, Qifa |
author_sort | Xu, Chenlin |
collection | PubMed |
description | Argus II retinal prosthesis is the US Food and Drug Administration (FDA) approved medical device intended to restore sight to a patient’s blind secondary to retinal degeneration (i.e., retinitis pigmentosa). However, Argus II and most reported retinal prostheses require invasive surgery to implant electrodes in the eye. Recent studies have shown that focused ultrasound can be developed into a non-invasive retinal prosthesis technology. Ultrasound energy focused on retinal neurons can trigger the activities of retinal neurons with high spatial-temporal resolution. This paper introduces a novel design and simulation of a ring array transducer that could be used as non-invasive ultrasonic retinal stimulation. The array transducer is designed in the shape of a racing ring with a hemisphere surface that mimics a contact lens to acoustically couple with the eye via the tear film and directs the ultrasound to avoid the high acoustic absorption from the crystalline lens. We will describe the design methods and simulation of the two-dimensional pattern stimulation. Finally, compared with other existing retinal prostheses, we show that the ultrasound ring array is practical and safe and could be potentially used as a non-invasive retinal prosthesis. |
format | Online Article Text |
id | pubmed-9503310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95033102022-09-24 Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation Xu, Chenlin Lu, Gengxi Kang, Haochen Humayun, Mark S. Zhou, Qifa Micromachines (Basel) Article Argus II retinal prosthesis is the US Food and Drug Administration (FDA) approved medical device intended to restore sight to a patient’s blind secondary to retinal degeneration (i.e., retinitis pigmentosa). However, Argus II and most reported retinal prostheses require invasive surgery to implant electrodes in the eye. Recent studies have shown that focused ultrasound can be developed into a non-invasive retinal prosthesis technology. Ultrasound energy focused on retinal neurons can trigger the activities of retinal neurons with high spatial-temporal resolution. This paper introduces a novel design and simulation of a ring array transducer that could be used as non-invasive ultrasonic retinal stimulation. The array transducer is designed in the shape of a racing ring with a hemisphere surface that mimics a contact lens to acoustically couple with the eye via the tear film and directs the ultrasound to avoid the high acoustic absorption from the crystalline lens. We will describe the design methods and simulation of the two-dimensional pattern stimulation. Finally, compared with other existing retinal prostheses, we show that the ultrasound ring array is practical and safe and could be potentially used as a non-invasive retinal prosthesis. MDPI 2022-09-16 /pmc/articles/PMC9503310/ /pubmed/36144157 http://dx.doi.org/10.3390/mi13091536 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Xu, Chenlin Lu, Gengxi Kang, Haochen Humayun, Mark S. Zhou, Qifa Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation |
title | Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation |
title_full | Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation |
title_fullStr | Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation |
title_full_unstemmed | Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation |
title_short | Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation |
title_sort | design and simulation of a ring transducer array for ultrasound retinal stimulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503310/ https://www.ncbi.nlm.nih.gov/pubmed/36144157 http://dx.doi.org/10.3390/mi13091536 |
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