Cargando…

Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana

The ubiquitous presence of nanoplastics (NPs) in natural ecosystems is a serious concern, as NPs are believed to threaten every life form on Earth. Micro- and nanoplastics enter living systems through multiple channels. Cell membranes function as the first barrier of entry to NPs, thus playing an im...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Mingyang, Zhang, Yuan, Li, Changyuan, Lin, Jinxing, Li, Xiaojuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503312/
https://www.ncbi.nlm.nih.gov/pubmed/36144641
http://dx.doi.org/10.3390/molecules27185906
_version_ 1784795932367257600
author Li, Mingyang
Zhang, Yuan
Li, Changyuan
Lin, Jinxing
Li, Xiaojuan
author_facet Li, Mingyang
Zhang, Yuan
Li, Changyuan
Lin, Jinxing
Li, Xiaojuan
author_sort Li, Mingyang
collection PubMed
description The ubiquitous presence of nanoplastics (NPs) in natural ecosystems is a serious concern, as NPs are believed to threaten every life form on Earth. Micro- and nanoplastics enter living systems through multiple channels. Cell membranes function as the first barrier of entry to NPs, thus playing an important biological role. However, in-depth studies on the interactions of NPs with cell membranes have not been performed, and effective theoretical models of the underlying molecular details and physicochemical behaviors are lacking. In the present study, we investigated the uptake of polyvinyl chloride (PVC) nanoparticles by Arabidopsis thaliana root cells, which leads to cell membrane leakage and damage to membrane integrity. We performed all-atom molecular dynamics simulations to determine the effects of PVC NPs on the properties of the multicomponent lipid bilayer. These simulations revealed that PVCs easily permeate into model lipid membranes, resulting in significant changes to the membrane, including reduced density and changes in fluidity and membrane thickness. Our exploration of the interaction mechanisms between NPs and the cell membrane provided valuable insights into the effects of NPs on membrane structure and integrity.
format Online
Article
Text
id pubmed-9503312
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95033122022-09-24 Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana Li, Mingyang Zhang, Yuan Li, Changyuan Lin, Jinxing Li, Xiaojuan Molecules Article The ubiquitous presence of nanoplastics (NPs) in natural ecosystems is a serious concern, as NPs are believed to threaten every life form on Earth. Micro- and nanoplastics enter living systems through multiple channels. Cell membranes function as the first barrier of entry to NPs, thus playing an important biological role. However, in-depth studies on the interactions of NPs with cell membranes have not been performed, and effective theoretical models of the underlying molecular details and physicochemical behaviors are lacking. In the present study, we investigated the uptake of polyvinyl chloride (PVC) nanoparticles by Arabidopsis thaliana root cells, which leads to cell membrane leakage and damage to membrane integrity. We performed all-atom molecular dynamics simulations to determine the effects of PVC NPs on the properties of the multicomponent lipid bilayer. These simulations revealed that PVCs easily permeate into model lipid membranes, resulting in significant changes to the membrane, including reduced density and changes in fluidity and membrane thickness. Our exploration of the interaction mechanisms between NPs and the cell membrane provided valuable insights into the effects of NPs on membrane structure and integrity. MDPI 2022-09-11 /pmc/articles/PMC9503312/ /pubmed/36144641 http://dx.doi.org/10.3390/molecules27185906 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Mingyang
Zhang, Yuan
Li, Changyuan
Lin, Jinxing
Li, Xiaojuan
Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana
title Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana
title_full Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana
title_fullStr Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana
title_full_unstemmed Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana
title_short Polyvinyl Chloride Nanoparticles Affect Cell Membrane Integrity by Disturbing the Properties of the Multicomponent Lipid Bilayer in Arabidopsis thaliana
title_sort polyvinyl chloride nanoparticles affect cell membrane integrity by disturbing the properties of the multicomponent lipid bilayer in arabidopsis thaliana
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503312/
https://www.ncbi.nlm.nih.gov/pubmed/36144641
http://dx.doi.org/10.3390/molecules27185906
work_keys_str_mv AT limingyang polyvinylchloridenanoparticlesaffectcellmembraneintegritybydisturbingthepropertiesofthemulticomponentlipidbilayerinarabidopsisthaliana
AT zhangyuan polyvinylchloridenanoparticlesaffectcellmembraneintegritybydisturbingthepropertiesofthemulticomponentlipidbilayerinarabidopsisthaliana
AT lichangyuan polyvinylchloridenanoparticlesaffectcellmembraneintegritybydisturbingthepropertiesofthemulticomponentlipidbilayerinarabidopsisthaliana
AT linjinxing polyvinylchloridenanoparticlesaffectcellmembraneintegritybydisturbingthepropertiesofthemulticomponentlipidbilayerinarabidopsisthaliana
AT lixiaojuan polyvinylchloridenanoparticlesaffectcellmembraneintegritybydisturbingthepropertiesofthemulticomponentlipidbilayerinarabidopsisthaliana