Cargando…

Hepatitis B Virus Research in South Africa

Despite being vaccine-preventable, hepatitis B virus (HBV) infection remains the seventh leading cause of mortality in the world. In South Africa (SA), over 1.9 million people are chronically infected with HBV, and 70% of all Black chronic carriers are infected with HBV subgenotype A1. The virus rem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maepa, Mohube B., Ely, Abdullah, Kramvis, Anna, Bloom, Kristie, Naidoo, Kubendran, Simani, Omphile E., Maponga, Tongai G., Arbuthnot, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503375/ https://www.ncbi.nlm.nih.gov/pubmed/36146747 http://dx.doi.org/10.3390/v14091939

Ejemplares similares

Gene Therapy for Chronic HBV—Can We Eliminate cccDNA?
por: Bloom, Kristie, et al.
Publicado: (2018)

Recent Update on the Role of Circular RNAs in Hepatocellular Carcinoma
por: Ely, Abdullah, et al.
Publicado: (2021)

In Vivo Modelling of Hepatitis B Virus Subgenotype A1 Replication Using Adeno-Associated Viral Vectors
por: Limani, Shonisani Wendy, et al.
Publicado: (2021)

Advances with RNAi-Based Therapy for Hepatitis B Virus Infection
por: van den Berg, Fiona, et al.
Publicado: (2020)

Progress and Prospects of Anti-HBV Gene Therapy Development
por: Maepa, Mohube B., et al.
Publicado: (2015)

Sustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs
por: Maepa, Mohube Betty, et al.
Publicado: (2017)

ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells
por: Scott, Tristan, et al.
Publicado: (2017)

Inhibition of Hepatitis B Virus Replication by Helper Dependent Adenoviral Vectors Expressing Artificial Anti-HBV Pri-miRs from a Liver-Specific Promoter
por: Mowa, Mohube Betty, et al.
Publicado: (2014)

Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases
por: Bloom, Kristie, et al.
Publicado: (2013)

The state of gene therapy research in Africa, its significance and implications for the future
por: Arbuthnot, P, et al.
Publicado: (2017)

Adenoviral Vectors: Potential as Anti-HBV Vaccines and Therapeutics
por: Farhad, Tasneem, et al.
Publicado: (2022)

Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA
por: Bloom, Kristie, et al.
Publicado: (2019)

Advances in designing Adeno-associated viral vectors for development of anti-HBV gene therapeutics
por: Mnyandu, Njabulo, et al.
Publicado: (2021)

Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric FokI Nuclease Domains
por: Smith, Tiffany, et al.
Publicado: (2021)

Low seroprevalence of hepatitis E virus in pregnant women in an urban area near Pretoria, South Africa
por: Simani, Omphile E., et al.
Publicado: (2021)

Hepatitis B virus-associated hepatocellular carcinoma in South Africa in the era of HIV
por: Maponga, Tongai Gibson, et al.
Publicado: (2020)

Silencing hepatitis B virus covalently closed circular DNA: The potential of an epigenetic therapy approach
por: Singh, Prashika, et al.
Publicado: (2021)

Diversity of Dysregulated Long Non-Coding RNAs in HBV-Related Hepatocellular Carcinoma
por: Samudh, Nazia, et al.
Publicado: (2022)

Advancing mRNA technologies for therapies and vaccines: An African context
por: Kairuz, Dylan, et al.
Publicado: (2022)

Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines
por: Kairuz, Dylan, et al.
Publicado: (2023)

Is hepatitis B birth dose vaccine needed in Africa?
por: Tamandjou, Cynthia Raissa, et al.
Publicado: (2017)

Efficient silencing of gene expression with modular trimeric Pol II expression cassettes comprising microRNA shuttles
por: Ely, Abdullah, et al.
Publicado: (2009)

Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa
por: Dickens, Caroline, et al.
Publicado: (2013)

HBV and HIV viral load but not microbial translocation or immune activation are associated with liver fibrosis among patients in South Africa
por: Maponga, Tongai Gibson, et al.
Publicado: (2018)

So far, no novel SARS-CoV-2 variants from Beijing—and hopefully better scientific cooperation going forward
por: Preiser, Wolfgang, et al.
Publicado: (2023)

Self-amplifying RNA vaccines for infectious diseases
por: Bloom, Kristie, et al.
Publicado: (2020)

Genotyping and Molecular Characterization of Hepatitis B Virus from Human Immunodeficiency Virus-Infected Individuals in Southern Africa
por: Makondo, Euphodia, et al.
Publicado: (2012)

Hepatitis B Virus: Infection, liver disease, carcinogen or syndemic threat? Remodelling the clinical and public health response
por: Matthews, Philippa C., et al.
Publicado: (2022)

Psychosocial Aspects During the First Wave of COVID-19 Infection in South Africa
por: Lentoor, Antonio G., et al.
Publicado: (2021)

No point in travel bans if countries with poor surveillance are ignored
por: Preiser, Wolfgang, et al.
Publicado: (2022)

Barriers that prevent adults living with HBV infection from participating in clinical research: experience from South Africa
por: Mofokeng, Nombuyiselo, et al.
Publicado: (2023)

The epidemiology of hepatitis B virus infection in HIV-infected and HIV-uninfected pregnant women in the Western Cape, South Africa()
por: Andersson, M.I., et al.
Publicado: (2013)

A blind spot? Confronting the stigma of hepatitis B virus (HBV) infection - A systematic review
por: Mokaya, Jolynne, et al.
Publicado: (2018)

Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis
por: McNaughton, Anna L., et al.
Publicado: (2020)

Self-Esteem and Resilience Differences Among Street Children Compared to Non-street Children in Limpopo Province of South Africa: A Baseline Study
por: Maepa, Mokoena Patronella
Publicado: (2021)

Viral hepatitis associated hepatocellular carcinoma on the African continent, the past, present, and future: a systematic review
por: Dakurah, Ottovon Bismark, et al.
Publicado: (2021)

Knowledge of final year medicine, pharmacy, audiology and nursing students in South Africa on drug-induced ototoxicity: A pilot study
por: Mogole, Omphile, et al.
Publicado: (2019)

Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection
por: Weinberg, Marc S, et al.
Publicado: (2010)

Evidence of tenofovir resistance in chronic hepatitis B virus (HBV) infection: An observational case series of South African adults
por: Mokaya, Jolynne, et al.
Publicado: (2020)

The clinical implications of hepatitis B virus genotypes and HBeAg in pediatrics
por: Kramvis, Anna
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ou65b07darm5lsai798rro14bo