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Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature

Background: High-titer convalescent plasma given early for COVID-19 may decrease progression into a severe infection. Here, we reported a study of serial antibody measurements in patients who received CP at our center and performed a systematic review of randomized trials on CP. Methods: Our center...

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Autores principales: Whang, Sonia N., Shah, Vivek D., Pu, Lu, Sheth, Parthiv, Lucas, Gina N., Lee, Joanne, Lee, Michael, Lacy, Curtis, Duerksen-Hughes, Penelope J., Filippov, Valeri, Lee, David J. H., Veltman, Jennifer, Maken, Kanwaljeet, Reeves, Mark E., Stevens, Wesley Tait, Herrmann, Paul, Cao, Huynh, Lau, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503397/
https://www.ncbi.nlm.nih.gov/pubmed/36145390
http://dx.doi.org/10.3390/pathogens11090958
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author Whang, Sonia N.
Shah, Vivek D.
Pu, Lu
Sheth, Parthiv
Lucas, Gina N.
Lee, Joanne
Lee, Michael
Lacy, Curtis
Duerksen-Hughes, Penelope J.
Filippov, Valeri
Lee, David J. H.
Veltman, Jennifer
Maken, Kanwaljeet
Reeves, Mark E.
Stevens, Wesley Tait
Herrmann, Paul
Cao, Huynh
Lau, Eric
author_facet Whang, Sonia N.
Shah, Vivek D.
Pu, Lu
Sheth, Parthiv
Lucas, Gina N.
Lee, Joanne
Lee, Michael
Lacy, Curtis
Duerksen-Hughes, Penelope J.
Filippov, Valeri
Lee, David J. H.
Veltman, Jennifer
Maken, Kanwaljeet
Reeves, Mark E.
Stevens, Wesley Tait
Herrmann, Paul
Cao, Huynh
Lau, Eric
author_sort Whang, Sonia N.
collection PubMed
description Background: High-titer convalescent plasma given early for COVID-19 may decrease progression into a severe infection. Here, we reported a study of serial antibody measurements in patients who received CP at our center and performed a systematic review of randomized trials on CP. Methods: Our center participated in the Mayo Clinic Expanded Access Program for COVID-19 Convalescent Plasma. Patients diagnosed with COVID-19 by nasopharyngeal polymerase chain reaction at our center between April and August 2020 were included in the study if staffing was available for specimen collection. Through a colloidal gold immunochromatography assay, these patients’ IgM and IgG antibody responses were measured at baseline (Day 0) and after transfusion (Day 1, 2, etc.). Donor CP antibody levels were measured as well. Results: 110 serum specimens were obtained from 21 COVID-19 patients, 16 of whom received CP. The median time from developing symptoms to receiving CP was 11 days (range 4–21). In 9 of 14 (64%) cases where both recipient and donor CP antibody levels were tested, donor COVID-19 IgG was lower than that of the recipient. Higher donor antibody levels compared with the recipient (R = 0.71, p < 0.01) and low patient IgG before CP transfusion (p = 0.0108) correlated with increasing patient IgG levels from baseline to Day 1. Among all patients, an increased COVID-19 IgG in the short-term and longitudinally was positively correlated with improved clinical outcomes (ρ = 0.69, p = 0.003 and ρ = 0.58, p < 0.006, respectively). Conclusions: In a real-world setting where donor CP was not screened for the presence of antibodies, CP in donors might have less COVID-19 IgG than in recipients. An increase in patient antibody levels in the short term and longitudinally was associated with improved clinical outcomes.
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spelling pubmed-95033972022-09-24 Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature Whang, Sonia N. Shah, Vivek D. Pu, Lu Sheth, Parthiv Lucas, Gina N. Lee, Joanne Lee, Michael Lacy, Curtis Duerksen-Hughes, Penelope J. Filippov, Valeri Lee, David J. H. Veltman, Jennifer Maken, Kanwaljeet Reeves, Mark E. Stevens, Wesley Tait Herrmann, Paul Cao, Huynh Lau, Eric Pathogens Article Background: High-titer convalescent plasma given early for COVID-19 may decrease progression into a severe infection. Here, we reported a study of serial antibody measurements in patients who received CP at our center and performed a systematic review of randomized trials on CP. Methods: Our center participated in the Mayo Clinic Expanded Access Program for COVID-19 Convalescent Plasma. Patients diagnosed with COVID-19 by nasopharyngeal polymerase chain reaction at our center between April and August 2020 were included in the study if staffing was available for specimen collection. Through a colloidal gold immunochromatography assay, these patients’ IgM and IgG antibody responses were measured at baseline (Day 0) and after transfusion (Day 1, 2, etc.). Donor CP antibody levels were measured as well. Results: 110 serum specimens were obtained from 21 COVID-19 patients, 16 of whom received CP. The median time from developing symptoms to receiving CP was 11 days (range 4–21). In 9 of 14 (64%) cases where both recipient and donor CP antibody levels were tested, donor COVID-19 IgG was lower than that of the recipient. Higher donor antibody levels compared with the recipient (R = 0.71, p < 0.01) and low patient IgG before CP transfusion (p = 0.0108) correlated with increasing patient IgG levels from baseline to Day 1. Among all patients, an increased COVID-19 IgG in the short-term and longitudinally was positively correlated with improved clinical outcomes (ρ = 0.69, p = 0.003 and ρ = 0.58, p < 0.006, respectively). Conclusions: In a real-world setting where donor CP was not screened for the presence of antibodies, CP in donors might have less COVID-19 IgG than in recipients. An increase in patient antibody levels in the short term and longitudinally was associated with improved clinical outcomes. MDPI 2022-08-23 /pmc/articles/PMC9503397/ /pubmed/36145390 http://dx.doi.org/10.3390/pathogens11090958 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Whang, Sonia N.
Shah, Vivek D.
Pu, Lu
Sheth, Parthiv
Lucas, Gina N.
Lee, Joanne
Lee, Michael
Lacy, Curtis
Duerksen-Hughes, Penelope J.
Filippov, Valeri
Lee, David J. H.
Veltman, Jennifer
Maken, Kanwaljeet
Reeves, Mark E.
Stevens, Wesley Tait
Herrmann, Paul
Cao, Huynh
Lau, Eric
Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature
title Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature
title_full Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature
title_fullStr Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature
title_full_unstemmed Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature
title_short Convalescent Plasma for COVID-19: A Single Center Prospective Experience with Serial Antibody Measurements and Review of the Literature
title_sort convalescent plasma for covid-19: a single center prospective experience with serial antibody measurements and review of the literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9503397/
https://www.ncbi.nlm.nih.gov/pubmed/36145390
http://dx.doi.org/10.3390/pathogens11090958
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